Introduction to GI Flashcards
Enteric nervous system
branch of ANS located entirely within GI tract.
what is enteric nerous sytem recieve regulation from
PNS and SNS
Is Ach excitiory or inhibitory
excititory
function of Ach
vasodilation
increased secretion
smooth muscle contraction
is NO excitiory or inhibitory
inhibitory
function of NO
vasocontriction
inhibit smooth muscle contraction
decreased secretions
is serotonin excitiory or inhibitory
excitory
function of serotonin
vasodilation
increased secretion
smooth muscle contraction
is dopamine excitory or inhibitory
inhibitory
function of dopamine
inhibit ENS neuronal firing
acts on presynaptic D2 cells
is NO excitiory or inhibitory
inhibitory
function of NO
smooth muscle relaxation
vascular and GI
is VIP excitory or inhibitory
inhibitory
function of VIP
smooth muscle relaxation
vascular and GI
What are the primary regulators of GI smooth muscle
Ach, VIP, NO
resting slow wave
continous depolarization and repolarization
spike potential
potential for rapid depolarization at peak of resting slow waves, given an appropriate stimulus
function of spinctors
regulate antegrade and retrograde movement
upper esophageal spincter
closed during inspiration
lower esophageal spincter
prevents reflux
pylorix sphicter
regulates gastric emptying
iocecal spincter
ileum distension relaxes
ascending colon distension causes contraction
internal anal spincter
involuntary control
distension of rectum relaxes sphincter
external anal spincter
volutnary contraction can override defecation reflex
key regulators of spincter opening
NO and VIP cause relazatino
Source of CCK
duodenum
target of CCK
pancrease, gallbladder, stomach, spincter of oddi
function of CCK
increase enzyme secretion
increase contraction
decrease gastric emptying
increase relaxation
source of gastrin
G cell
target of G cell
parietal, ECL, D cell
function of gastrin
promote gastric acid secretion
source of motilin
upper GI
target of motilin
stomach, duodenum
action of motilin
increase smooth muscle contraction (key player in MMC)
source of peptide YY
ileum, colon
target of peptide YY
panacrease
action of peptide YY
decrease enzyme and fluid secretion
source of secretin
duodenum
target of secretin
pancreas, stomach
action of secretin
increase bicard secretion
decrease acid secretion
delay gastric emptying
source of somatostatin
stomach, duodenum, pancreatic cells
target of somatostatin
stomach, intestine, pancreas, liver
action of somatostatin
decrease acid secretion
increase fluid absorption
decrease secretions
decrease bile flow
source of prostaglandin
stomach, intestine/immune cells
target of prostaglandin
stomach, intestine
action of prostatgland on the stomach
increase blood flow
decrease acid secretion
increase mucus/bicab secretion
action of prostaglandin on intestine
increase motility
increase fluid secretion
source of histamine
stomach, intestine/immune cells
target of histamine
stomach, intestine
affect of histamine on stomach
increase acid secretion
affect of histamine on intestine
increase fluid secretion