Introduction to GI Flashcards

1
Q

Enteric nervous system

A

branch of ANS located entirely within GI tract.

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2
Q

what is enteric nerous sytem recieve regulation from

A

PNS and SNS

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3
Q

Is Ach excitiory or inhibitory

A

excititory

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4
Q

function of Ach

A

vasodilation
increased secretion
smooth muscle contraction

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5
Q

is NO excitiory or inhibitory

A

inhibitory

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6
Q

function of NO

A

vasocontriction
inhibit smooth muscle contraction
decreased secretions

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7
Q

is serotonin excitiory or inhibitory

A

excitory

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8
Q

function of serotonin

A

vasodilation
increased secretion
smooth muscle contraction

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9
Q

is dopamine excitory or inhibitory

A

inhibitory

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10
Q

function of dopamine

A

inhibit ENS neuronal firing

acts on presynaptic D2 cells

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11
Q

is NO excitiory or inhibitory

A

inhibitory

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12
Q

function of NO

A

smooth muscle relaxation

vascular and GI

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13
Q

is VIP excitory or inhibitory

A

inhibitory

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14
Q

function of VIP

A

smooth muscle relaxation

vascular and GI

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15
Q

What are the primary regulators of GI smooth muscle

A

Ach, VIP, NO

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16
Q

resting slow wave

A

continous depolarization and repolarization

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17
Q

spike potential

A

potential for rapid depolarization at peak of resting slow waves, given an appropriate stimulus

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18
Q

function of spinctors

A

regulate antegrade and retrograde movement

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19
Q

upper esophageal spincter

A

closed during inspiration

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20
Q

lower esophageal spincter

A

prevents reflux

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21
Q

pylorix sphicter

A

regulates gastric emptying

22
Q

iocecal spincter

A

ileum distension relaxes

ascending colon distension causes contraction

23
Q

internal anal spincter

A

involuntary control

distension of rectum relaxes sphincter

24
Q

external anal spincter

A

volutnary contraction can override defecation reflex

25
Q

key regulators of spincter opening

A

NO and VIP cause relazatino

26
Q

Source of CCK

A

duodenum

27
Q

target of CCK

A

pancrease, gallbladder, stomach, spincter of oddi

28
Q

function of CCK

A

increase enzyme secretion
increase contraction
decrease gastric emptying
increase relaxation

29
Q

source of gastrin

A

G cell

30
Q

target of G cell

A

parietal, ECL, D cell

31
Q

function of gastrin

A

promote gastric acid secretion

32
Q

source of motilin

A

upper GI

33
Q

target of motilin

A

stomach, duodenum

34
Q

action of motilin

A

increase smooth muscle contraction (key player in MMC)

35
Q

source of peptide YY

A

ileum, colon

36
Q

target of peptide YY

A

panacrease

37
Q

action of peptide YY

A

decrease enzyme and fluid secretion

38
Q

source of secretin

A

duodenum

39
Q

target of secretin

A

pancreas, stomach

40
Q

action of secretin

A

increase bicard secretion
decrease acid secretion
delay gastric emptying

41
Q

source of somatostatin

A

stomach, duodenum, pancreatic cells

42
Q

target of somatostatin

A

stomach, intestine, pancreas, liver

43
Q

action of somatostatin

A

decrease acid secretion
increase fluid absorption
decrease secretions
decrease bile flow

44
Q

source of prostaglandin

A

stomach, intestine/immune cells

45
Q

target of prostaglandin

A

stomach, intestine

46
Q

action of prostatgland on the stomach

A

increase blood flow
decrease acid secretion
increase mucus/bicab secretion

47
Q

action of prostaglandin on intestine

A

increase motility

increase fluid secretion

48
Q

source of histamine

A

stomach, intestine/immune cells

49
Q

target of histamine

A

stomach, intestine

50
Q

affect of histamine on stomach

A

increase acid secretion

51
Q

affect of histamine on intestine

A

increase fluid secretion