Autonomics

Question 1

ANS is a part of what

Answer 1

peripheral nervous system

Question 2

sympathetic nervous system location

Answer 2

T1-L3

nervous line in lateral horn of spinal cord

Question 3

What is Ach

Answer 3

preganglion NT

Question 4

what is NE

Answer 4

postganglionic NT

Question 5

parasympathetic nerves

Answer 5

CN III, VII, IX, X

Sacral S2-4

Question 6

path of long pre-ganglionic nercous

Answer 6

pelvic ganglia to short post-ganglionic fibers to target

Question 7

path of shorter preganglionic neous

Answer 7

paravertebral, prevertebral or specialized ganglia to longer post ganglionic nerous to target

Question 8

How is Ach syntheized

Answer 8

choline transporter takes choline into cell, then conjugated to acteyl coA via choline acetyltransferase

Question 9

Hemicholiniums

Answer 9

blocks choline transporter taking choline into cell

Question 10

how is Epi synthesized

Answer 10

tyrosine to DOPA to doapmine to NE to Epi

Question 11

metyrosin

Answer 11

blocks conversion of tyrosin to DOPA

Question 12

how is ach stored

Answer 12

VAT brings Ach into vesicle

Question 13

vesamicole

Answer 13

blocks VAT bringing Ach into vesicle

Question 14

how is Epi stored

Answer 14

VMAT transports into vesicles where synthesis increases

Question 15

reserpine

Answer 15

blocks WMAT transport into vesicles

Question 16

how is ach released

Answer 16

depolarization caused by ca++ influx with calmodulin activates VAMPS and SNAPs

Question 17

botulinum

Answer 17

blocks release of Ach

Question 18

How is Epi released

Answer 18

similiar to Ach

Question 19

bretylium

Answer 19

blocks release of epi

Question 20

how is Ach terminated

Answer 20

acetylcholinesterase hydrolyzes Ach in synaptic cleft

Question 21

How is epi terminated

Answer 21

diffusion at synapse into circulation

reuptake via NET1 or NET2, then metabolized by MAO following reuptake