Autonomics Flashcards
ANS is a part of what
peripheral nervous system
sympathetic nervous system location
T1-L3
nervous line in lateral horn of spinal cord
What is Ach
preganglion NT
what is NE
postganglionic NT
parasympathetic nerves
CN III, VII, IX, X
Sacral S2-4
path of long pre-ganglionic nercous
pelvic ganglia to short post-ganglionic fibers to target
path of shorter preganglionic neous
paravertebral, prevertebral or specialized ganglia to longer post ganglionic nerous to target
How is Ach syntheized
choline transporter takes choline into cell, then conjugated to acteyl coA via choline acetyltransferase
Hemicholiniums
blocks choline transporter taking choline into cell
how is Epi synthesized
tyrosine to DOPA to doapmine to NE to Epi
metyrosin
blocks conversion of tyrosin to DOPA
how is ach stored
VAT brings Ach into vesicle
vesamicole
blocks VAT bringing Ach into vesicle
how is Epi stored
VMAT transports into vesicles where synthesis increases
reserpine
blocks WMAT transport into vesicles
how is ach released
depolarization caused by ca++ influx with calmodulin activates VAMPS and SNAPs
botulinum
blocks release of Ach
How is Epi released
similiar to Ach
bretylium
blocks release of epi
how is Ach terminated
acetylcholinesterase hydrolyzes Ach in synaptic cleft
How is epi terminated
diffusion at synapse into circulation
reuptake via NET1 or NET2, then metabolized by MAO following reuptake
