pancreas Flashcards

1
Q

what is the endocrine component of the pancreas?

A

islets of langherhans

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2
Q

how many cell types does the islet of langherhans have? what are they?

A

5

  1. Alpha cells
  2. Beta cells
  3. Delta cells
  4. G cells
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3
Q

what do alpha cells produce?

A

glucagon

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4
Q

what do beta cells produce?

A

insulin

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5
Q

what do delta cells produce?

A

somatostatin

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6
Q

what do G cells produce?

A

gastrin

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7
Q

what is the exocrine pancreas composed of?

A

acini

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8
Q

what do acini have in their lumen?

A

centroacinar cells

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9
Q

what do acini produce?

A

digestive enzymes

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10
Q

what causes the pancreas to release enzymes?

A

cholecystokinin

acetylcholine

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11
Q

what are the pancreatic enzymes?

A

pancreatic amylase

pancreatic lipase

ribonuclease

deoxyribunuclease

elastase

proenzymes: chemotrypsinogen and trypsinogen

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12
Q

who produces bicarbonate?

A

centroacinar and striated ductal cells

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13
Q

what does bicarbonate do?

A

neutralize stomach acids

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14
Q

who regulates bicarbonate buffer?

A

secretin

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15
Q

where does the endocrine pancreas empty into?

A

in to the bloodstream

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16
Q

where does the exocrine pancreas empty into?

A

into intestines

17
Q

what is the pink big circle?

A

islet of langherhans

18
Q

what is this?

A

pancreas

19
Q

what is circled here?

A

acini

20
Q

what does insulin promote?

A

uptake of glucose and storage of it as glycogen

21
Q

what is a tell-tale sign of diabetes?

A

glucose in the urine

22
Q

what is type 1 diabetes?

A

you have too little insulin

23
Q

what is type 2 diabetes?

A

inactive insulin receptors

24
Q

what is type 3 Diabetes?

A

lack of insulin receptors in the brain

25
Q

what does glucagon do?

A

it increases levels of blood glucose through gluconeogenesis

26
Q

what does somatostatin do?

A

it inhibits insulin and glucagon secretion

27
Q

what does gastrin do?

A

promote stomach motility and secretion

28
Q

what is pancreatitis?

A

pancreas digests itself

29
Q

what causes acute pancreatitis?

A

gallstones

30
Q

what causes chronic pancreatitis?

A

alchohol

31
Q

what will you see in the plasma?

A

increased levels of amylase and lipase

32
Q

does pancreatic cancer have a good prognosis?

A

no; 1 year

33
Q

what is the most common type of pancreatic cancer?

A

adenocarcinoma

34
Q

what is happening here?

A

adenocarcinoma of pancreas