PAIN, INFLAMMATION, AND TISSUE HEALING Flashcards
PHASES OF TISSUE HEALING
Inflammation Phase (1 - 6th day)
Proliferation Phase (3rd to 20th day)
Maturation Phase (9th day onwards)
What are the goals of Infllamation phase?
Restore function in 3 ways
(1) eliminate the pathological insult
(2) replacing damaged tissue
(3) restore function to promote regeneration of normal tissue structure
Phase ion tissue healing wherei it prepares the wound injured tissue for healing
Inflammation Phase (1 - 6th day)
T or F
Calor (Heat, it increases the metabolic rate),
Rubor (Redness,),
TRUE
Cardinal signs of Inflammation
Calor
Rubor
Tumor
Dolor
Functio Laesa
T or F
Tumor (loss of function, pain and swelling impedes the ROM)
Dolor (Pain, pain receptors are stimulated by chemical and mechanical stimuli),
Functio Laesa (Swelling, vasodilation and and increase capillary permeability)),
FALSE
Tumor (Swelling, vasodilation and and increase capillary permeability)),
Dolor (Pain, pain receptors are stimulated by chemical and mechanical stimuli),
Functio Laesa (loss of function, pain and swelling impedes the ROM)
Inflammation Phase (1 - 6th day)
: it prepares the wound injured tissue for healing
initiates the healing process also called __or inflam___mo (to set alight or set on fire)
called Inflammer or inflammo (to set alight or set on fire)
What occurs during the Inflammatory phase?
Vasoconstriction of injured BV
Vasodilation of adjacent uninjured BV
Clot formation
Phagocytosis by WBCs
Alteration in the anatomy and function of the microvascular system
Goal; INCREASE THE MOVEMENT OF PLASMA PROTEINS AND FLUID OUT OF THE VASCULAR SPACE INTO THE SITE OF INJURY
Vascular Response
Psychological response: Hemostatic Response to ruptured/injured skin
controls blood loss when vessels are injured
clot information
Fibrin + Fibronectin + Collagen will form?
Fibrin Lattice Formation
4 mechanisms that cause increased permeability
endothelial cell contraction
result of direct endothelial injury
leukocyte-dependent endothelial injury
Leakage by regenerating capillaries that lack differentiated endothelium
Which is correct?
Neutrophils - 3rd line of defense
Basophils - release antigen I
Monocyte - premature (inactive) macrophages
All are correct
All are wrong
Neutrophils - 1st line of defense
Basophils - release histamine
Monocyte - premature (inactive) macrophages
T of F
Monocytes - promote phagocytosis
FALSE
Macrophages - promote phagocytosis
LEUKOCYTIC EVENTS DURING INFLAMMATION (4)
Pavementing
Margination
Diapedesis
Chemotaxis
3 MAJOR CONSEQUENCES OF INFLAMMATION
->Fibrin, Fibronectin, and collagen crosslink to form a Fibrin Lattice that limits blood abd provides the wound with initial strength
-> Neutrophils followed by macrophages begin to remove damaged tissue
-> Endothelial cells and fibroblasts are recruited and are stimulated to divide
T or F
Fibroblast - produces collagen
TRUE
Goal of the Proliferation Phase
Achieve coalescence and closure of injured area
Involves epithelial cells and connective tissue
The wound is covered, and the injury site starts to regain some of some of its initial strength
Rebuilds damaged structures and strengthen the wound
Proliferation Phase
Burn patients will likely die from?
Dehydration
Reestablishment of epidermis
Create new epithelial cells.
these are under Proliferation phase of healing in what event?
Epithelialization
During Epithelialization will all types of wound under go this at the same phase?
If yes, What will decide which will under go first?
initiation depends on the depth of wound
if the wound is superficial, epithelialization occurs immediately, if deep, it occurs later
Process of Epithelialization
Basal cells attach themselves on basal membrane
Holds the parent cells and pulls to the center to close the wound
Contact inhibition - cells will stop moving after contact
Basal cells will differentiate and proliferate
Walang
