Pain! Flashcards
Factor’s influencing pain
3
Patient’s fear of what is causing the pain- when they find out it is lessened
Psychological stressors and past pain experiences
Pain “threshold”**
Acute/Temporary Pain Treatment
steps?
3
- Identify source of pain:
- Remove the cause if possible
- There is a lag period before pain subsides
- Treat pain EARLY before it has increased to a level where it is more difficult to control** - Use the least potent analgesic w/ the fewest side effects
- Properly titrate the dose & administer for an adequate amount of time
Mechanism of action for acetaminophen?
3
Weak COX-1 & COX-2 inhibitor in peripheral tissues
Decreases pain but has NO anti-inflammatory effect
Anti-pyretic
Doasge for acetominophen?
max daily dose?
4000mg
4grams per day
Onset of acetominophen?
15 to 30 min
Side effects of acetominophen?
3
Large doses can cause liver toxicity & be lethal
Large doses can cause dizziness and disorientation
Renal damage can occur even w/ normal dosages!
Mechanism of action for aspirin?
4
- Inhibits COX and platelet aggregation
- reduces pain by reducing inflammation
- Anti-pyretic
- Lower incidence of colon cancer and decreases DVT after CABG
Side effetcs of aspirin?
3
Gastric upset and ulcers
Hepatotoxicity and renal toxicity
Asthma and rashes
What is salicylism?
vomiting, tinnitus, decreased hearing and vertigo are reversible by reducing the dosage
What will toxic levels of aspirin cause?
4
- metabolic acidosis
- respiratory depression
- cardiotoxicity
- Overdoses are a medical emergency
Mechanism of action in NSAIDs?
Decreases prostaglasdins!! main mechanism of action
Non selective for COX1 and COX2
What do prostagladins cause?
inflammation
So acetominophen is a weak COX inhibitor. What does this indicate about inflammation?
Since it is a weak inhibitor it does not decrease prostaglandin activity and thus does not decrease inflammation
What are the physiological effects of prostaglandin?
5
- Activation of the inflammatory response
- Elicitation of pain and fever
- Contraction and relaxation of smooth muscle** (can help with pain there)
- Inhibition of acid synthesis and increased secretion of the protective mucus in the stomach
- Increased blood flow to the kidneys
Why is prostaglandin good for the GI tract?
can help with pain there because it controls contraction and relaxation of smooth muscle
inhibits acid synthesis and increases protective mucous for the stomach
GI Side Effects of NSAIDs?
4
N/V,
heartburn,
ulcers/bleeding,
diarrhea
Cant pregnant women take NSAIDS?
They shouldnt but can while lactating and postpartum
Renal side effects of NSAIDS
4
- Salt and water retention
- HTN**
- Can be particularly damaging if patient is taking other nephrotoxic drugs
- Interferes w/ platelet aggregation for 2-4 days
NSAIDs can cause photosensitivity
statement
What kind of patients do we see experiencing adverse renal events and acute kidney injury?
4
- Chronic kidney disease (decreased GFR)
- Volume depletion (diuresis, vomiting, diarrhea)
- CHF, nephrotic syndrome or cirrhosis
- Older age
Max dose for ibuprofen?
3200mg
Max dose for Naproxen (aleve)?
1000mg
What are COX-2 inhibitors good for?
3
They are just as effective as other NSAIDs
Less GI toxic
Good for treating artritis
Considerations/risk for gastroduodenal toxicity in NSAIDS?
Age >65 Use of anticoagulant therapy Previous GI bleed Acute PUD Concomitant use of glucocorticoids (if on steriods give them something else besides both can cause ulcers)
Opiod indications?
3
Acute postop pain
Severe pain for a limited duration
Chronic pain (by experienced provider)
MOA for opiods?
often inhibit Mu receptors in the CNS
What are Mu and Beta recetors for opiods associated with?
endorphins
What are delta receptors for opiosd associated with?
enkephalins
What are kappa receptors associated with?
dynorphins
Describe nociceptive pain?
cut your skin and it hurts where you cut it
Describe neuropathic pain?
neuropatnhy- nerves are causing symptoms of numbness adn tingling. source of pain is somewhere else
Side effects of opioids?
3
Constipation
Sedation
Addiction
are the big three
Everytime you prescribe an topioid what do you need to tell the patient?
4
Address ahead of time—constipation**
Warn of addiction
Sedation
Nausea and vomiting—may want to prescribe an anti-emetic
What causes the euphoria in opioids?
release of dopamine
Whats the difference between physical dependence and addiction?a
addiciton is the physcological dependance
If we push morphine too fast what can happen?
Hypotension (low BP)
Can you write for demerol pills?
NO, only IV and IM
How would the onset and duraiton of action differ in methadone than in other opioids?
Extended duration of action and slow onset of action
Side effects fo methadone?
3
Hypoglycemia
Hyponatremia
Death: prolonged QT interval—torsade de pointes
Methadone does not causes euphoria!
Statment
Oxycodone and acetominophen make what?
percocet
Oxycodone and aspirin make what?
percadan
Hydrocodone/acetaminophen makes what?
vicoden
Hydrocodone/ASA makes what?
Lortab
What is narcan used for?
opioid reversal medication
Only to get them breathing again not to reach full alertness
What kind of agonist is fentanyl?
What are its dosage forms?3
A very strong mu opioid agonist
Available in IV, transdermal patch and suckers
MOA of tramadol?
inhibits reuptake of epi and norepi
Side effects of tramadol?
3
- HA, dizziness
- Nausea, constipation (low risk for GI bleeding)
- Somnolence-stonrg desire to sleep
Purposes of a pain contract?
3
- To provide informed consent regarding risks and benefits of opioid treatment
- To foster adherence to the treatment program and limit the potential for abuse
- To improve the efficacy of the pain treatment program
What are Tricyclic Antidepressants (TCAs) used for regarding pain?
chronic pain states especially neuropathic pain
Issues with prescribing TCAs for pain?
We prescrib eit at a much lower dose than for depression and titrate up from there. This leads to the drug taking much longer to work and we mind not see any effects for 4-6 weeks or not at all
Side effect categories for TCAs?
4
Anticholinergic -Neurologic
Cardiovascular -Gastrointestinal
Contraindicated for patients with?
4
severe cardiac diseas
conduction disturbances
get a pretreatment EKG
Avoid completely with patients with GI dysfunciton
What is the most common TCA given for neuropathic pain?
Amitriptyline (Elavil):
Strong anticholinergic effect
What are anticonvulsants used for in treating pain?
Used for the treatment of neuropathic pain and other mild/moderate chronic pain states
MOA for neurontin?
Binds to voltage gated ca channel sites
Why is neurontin usually used first line?
Well tolerated, effectivie and cheap
What do we not use Neurontin for?
trigeminal neuralgia
Side effects of neurontin?
4
Somnolence, Ataxia (thats why we start slow)
Nausea, diarrhea
Dizziness, fatigue
Mood swings
What is pregabalin used for (lyrics?)
peripheral neuropathy and fibromyalagia