Pain

Question 1

Paracetamol class

Answer 1

Analgesic & antipyretic

Question 2

NSAIDs class

Answer 2

Analgesic, antipyretic & anti-inflammatory

Question 3

Types of NSAIDS

Answer 3

aspirin, ibuprofen, diclofenac, naproxen, indomethacin

Question 4

Celecoxib & meloxicam

Answer 4

Selective NSAIDs

Question 5

NSAID drug interactions

Answer 5

warfarin, ACE inhibitors, diurectics, sartans, lithium, MTX, corticosteroids

Question 6

Triple Whammy

Answer 6

Diuretics, ACE inhibitors & NSAIDS

Question 7

First line of tx for RA (type of csDMARD)

Answer 7

Methotrexate (folic acid antagonist)- ONLY TO BE TAKEN ONCE PER WEEK

Question 8

Cautions of methotrexate

Answer 8

Hepatic- toxicity
Children- specialist treatment
Pregnancy- avoid
Breastfeeding- avoid
Renal- not for mod-severe impairment

Question 9

Second line of tx for RA (type of bDMARD)

Answer 9

Infliximab (TNF-alpha antagonist)
- IV only
- Taken with antihistamine/corticosteroid to reduce severity of ADRs
- Can take up to 12 weeks for effect
- Given every 6-8 weeks once maintenance dose reached

Question 10

Cautions for infliximab

Answer 10

Hepatic- avoid
Children- avoid
Pregnancy- avoid
Breastfeeding- on specialist advice

Question 11

Which type of pain is most effectively managed with opioids

Answer 11

Nociceptive

Question 12

What type of pain is Amitriptyline used for?

Answer 12

Neuropathic