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601 > Asthma > Flashcards

Asthma Flashcards

1
Q

What is asthma

A

Chronic airway inflammation

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2
Q

Symptoms

A

increased mucus production, thickened bronchial walls, wheeze, SOB, chest tightness, cough, expiratory airflow limitation

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3
Q

Good control

A

Daytime symptoms <2 days per week
Need for reliever <2 days
No limitation on activities
No symptoms during the night or on waking

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4
Q

ICS

A

Inhaled corticosteroid

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5
Q

Salbutamol & terbutaline

A

SABA (3-4mins, lasts 3-4hours)

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6
Q

MOA for SABAs

A

agonists of beta 2 adrenergic receptors in the lungs cause bronchodilation by relaxing bronchial smooth muscles, allowing the airways to open

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7
Q

Cautions for SABAs

A

Elderly- titrate slowly
Hepatic- safe
Children- safe for >2
Pregnancy- safe
BF- safe
Renal- safe

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8
Q

Salmeterol, eformoterol & indacaterol

A

LABA (preventors)

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9
Q

MOA for LABA

A

agonists of beta 2 adrenergic receptors activate these receptors in the bronchial smooth muscle to allow for relaxation and bronchodilation

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10
Q

Cautions for LABA

A

Elderly- titrate slowly
Hepatic- safe
Children- safe for >2
Pregnancy- limited data
BF- salmeterol is safe
Renal- safe

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11
Q

beclomethason, budesonide & fluticasone

A

ICS (maintenace therapy- can be combined with LABA)

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12
Q

MOA for ICS

A

immunosuppressant reduces airway inflammation and bronchial hyper reactivity

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13
Q

Cautions for ICS

A

Elderly- more susceptible to skin thinning and bruising, reduce
Hepatic- safe
Children- avoid high doses
Pregnancy- safe
BF- safe
Renal- safe
Caution- in COPD (pneumonia risk)

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14
Q

ipratropium

A

SAMA inhaled anticholinergics

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15
Q

MOA for inhaled anticholinergic

A

antagonists of cholinergic receptors in the bronchial tissue relax smooth muscle to allow bronchodilation

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16
Q

tiotripium

A

LAMA inhaled anticholinergics

17
Q

Cautions for inhaled anticholinergic

A

Elderly- more susceptible to retention
Hepatic- safe
Children- SAMA safe not LAMA
Pregnancy- safe
BF- safe
Renal- safe
Caution- not to use if bladder obstruction/retention

601 (9 decks)

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