MISC

Question 1

Pharmacodynamics

Answer 1

Effect of drug in the body
Relationship between the concentration of drug at the site of action and effect

Question 2

Efficacy

Answer 2

term to describe the maximum response produced by a drug

Question 3

Potency

Answer 3

concentration (EC 50) or dose (ED50) that is required to produce 50% of the drugs maximum effect

Question 4

Agonist

Answer 4

Activates a receptor to produce a response

Question 5

Antagonist

Answer 5

Has receptor affinity but no efficacy and can prevent agonists from activating a response

Question 6

Pharmacokinetics

Answer 6

What body does to drug
Process includes ADME
Processes determine the relationship between drug dose and its concentration at the site of action

Question 7

Bioavailability

Answer 7

Fraction of the dose that reaches the systemic circulation from the site of the dose administration

Question 8

What does MESS stand for

Answer 8

Mechanism, Evidence, Severity, Symptoms

Question 9

4 pillars of QUM

Answer 9

Safety, efficacy judiciousness, appropriateness

Question 10

Category A

Answer 10

No proven increase in frequency of malformations

Question 11

Category B

Answer 11

B1- only taken by limited number, no increase in frequency of malformation (animal studies shown no evidence)
B2- only taken by limited number, no increase in frequency of malformation (animal studies lacking)
B3- limited number, no increase (animal studies shown evidence of damage)

Question 12

Category C

Answer 12

drugs have caused or suspected cause of harmful effects (reversible)

Question 13

Category D

Answer 13

drugs have caused or suspected cause of increased harm (irreversible)