Paeds Flashcards
Commonest cause of neck lump in children
Lymphadenopathy, history of local infection or general illness
Lymphoma characteristics
Rubbery, painless lymphadenopathy. Associated night sweats and splenomegaly.
Thyroid cyst appearance
Midline between isthmus and hyoid bone, moves upward on protrusn of the tongue. If infected can be painful
What is a cystic hygroma
Congenital lymphatic lesion typically found in the neck
Brachial cyst presentation
Oval, mobile cyst that develops between sternocleidomastoid muscle and the pharync.
What is cervical rib
More common in adult females, cause of thoracic outlet syndrome
Hodgkin lymphoma summary
Reed-Sternberg cell, painless lymphadenopathy (large), B symptoms often uncommon
Diagnosis of Hodgkin lymphoma
Biopsy
Management of Hodgkin lymphoma
Chemo +/- radiotherapy 80% cured
Non-Hodgkin lymphoma summary
May affects B or T cells. Much more common and more common in elderly, may cause vena cava obstruction (facial flushing/swelling)
What is Burkitt’s lymphoma
High-grade B-cell neoplasm, usually in African, malaria endemic areas. Tumour of facial bones
What virus is associated with Burkitt’s lymphoma
EBV - found in almost all cases. Chronic malaria is thought to reduce resistance to this
Peak incidence of ALL
2-5 years old, boys slightly more affected, 80% of childhood leukaemias
Features of ALL
Anaemia (lethargy and pallor)
Neutropaenia (frequent infection)
Thrombocytopaenia (easy bruising, petechiae)
Other features of ALL
Bone pain (secondary to bone marrow infiltration) Splenomegaly Hepatomegaly Fever Testicular swelling
Investigations in ALL
Low Hb Thrombocytopenia Circulating leukaemic BLAST CELLS ON BLOOD SMEAR DIC LP CXR - mediastinal maas (T cell disease)
How is ALL diagnosed
Bone marrow biopsy
What is Wilms tumour
Renal tumour, usually present before 5 with large abdominal mass and haematuria.
Quick retinoblastoma summary
Autosomal dominant, most within first 3 years of life, white pupillary reflex replacing red. May have squint
Glucose-6-dehydrogenase deficiency
Neonatal jaundice, haemolysis causing fever, malaise, abdo pain and dark urine. Precipitated by infection, broad beans and drugs. X-linked recessive
Hereditary spherocytosis summary
Sphere RBCs, commonly presents as neonatal jaundice, anaemia, splenomegaly, aplastic crisis (caused by parvovirus B19). Oral folic acid needed
Most common causative organism for UTI in children
E.coli (80%), proteus, pseudomonas
Predisposing factors for UTI
Infrequent voiding, hurried micturition, neuropathic bladder, vesicoureteric reflux, poor hygiene, STRUCTURAL ABNORMALITY
Presentation of UTI in childhood
Infants - poor feeding, vomiting, irritability
Younger children - abdo pain, fever, dysuria
Older children - dysuria, frequency, haematuria
What features would suggest an upper UTI
Fever >38, loin pain/tenderness
Management of UTI in children
<3 months - referred immediately to paediatrician
Upper UTI admit to hospital (cephalosporin/co-amox for 7-10 days)
>3 months lower UTI - trimethoprim or nitrofuratonin
What is the triad of haemolytic uraemic syndrome
Acute kidney injury
Microangiopathic haemolytic anaemia
Thrombocytopenia
What is the commonest cause of haemolytic uraemic syndrome
E.coli (Shiga toxin producing type)
Also: HIV, pneumococcal infection, SLE
Management of haemolytic uraemic syndrome
Fluids, blood transfusion/dialysis if needed.
Which cranial nerve is most likely to be affected by raised ICP
Abducens VI because it has a very long intracranial course
Red flag symptoms for headache
Growth failure, new onset squint, worse in mornings, torticollis, ataxia, papilloedema, abnormal gait
Prophylactic treatment for migraine
sodium channel blockers (valproate), propranolol
What is a generalised epileptic attack
Arrises from both hemispheres
Investigations for epilepsy
ECG is recommended in all as don’t want to miss long-QT syndrome. EEG if epilepsy suspected
What is West syndrome
Infantile spasms - flexion of head and trunk followed by extension of the arms often on waking
Side effects of valproate
Weight gain, hair loss, teratogenic
Side effects of carbamazepine
Rash, hyponatraemia, ataxia
Side effects of lamotrigine
Rash, insomnia, ataxia
What diet can be used in epilepsy
Ketogenic (high fat, low carb)
Types of muscular dystrophies
Duchenne, Becker, congenital
Features of Duchenne muscular dystrophy
X-linked recessive, deletion of dystrophin gene. Present with waddling gait at around 5 years. Corticosteroids help, CPAP overnight.
What is Becker muscular dystrophy
Same gene as Duchenne, a less severe form and presents later
Brain haemorrhage in children
Most common extradural from injury - lucid interval where seem okay.
Subdural indicates shaken baby syndrome
SAH very rare
Conditions tested for in newborn screening
Cystic fibrosis, sickle cell disease, congenital hypothyroidism, phenylketonuria, galactosaemia, homocytinuria
5 Signs of kernicterus
Irritability, poor feeding, seizures, coma, opisthotonus (muscle spasm)
Diseases associated with Down’s syndrome
Atrioventricular septal defect, duodenal atresia, Hirschprung’s disease, hypothyroidism, coeliac disease, apnoea, leukaemia, Alzheimer’s
What chromosome abnormality is Edwards syndrome
Trisomy 18
What chromosome abnormality is Patau syndrome
Trisomy 13
What chromosome abnormality is Turner’s syndrome
45 X
3 signs of Turner’s syndrome on foetal ultrasound
Foetal oedema of neck hands and feet
Cystic hygroma
Structural heart/kidney defects
What chromosome abnormality is fragile X
X-linked recessive - trinucleotide repeat
What blood test result would indicate Duchenne’s muscular dystrophy
Raised creatinine kinase
Duchenne’s muscular dystrophy mode of inheritance
X-linked recessive
Features of congenital adrenal hyperplasia
Low mineralocorticoids - vomiting, dehydration, weight loss. Loow cortisol - hypoglycaemia, clitoral hypertrophy, penis enlargement
What is the risk of treating hyponatraemia quickly
Cerebral oedema causing damage to myelin sheath in brainstem (pons). Can cause paralysis, dysphagia and dysarthria
X-ray finding for tetralogy of Fallot
Boot-shaped heart, right sided aortic arch
4 causes of heart failure in the neonate
Severe coarctation of the aorta
Critical aortic valve stenosis
Hypoplastic left heart syndrome
Interruption of the aortic arch
3 causes of heart failure in infant
(due to L-R shunt)
VSD
ASD
Patent ductus arteriosus
3 causes of heart failure in older child
Eisenmenger syndrome
Rheumatic heart disease
Cardiomyopathy
3 factors which contribute to airway narrowing in asthma
Bronchial muscle contraction
Mucosal inflammation
Increased mucous production
Severe asthma attack features
Inability to complete sentences
Pulse >140
RR >40 (>5yrs)
Peak flow 35-50% predicted
Features of life threatening asthma attack
Silent chest LOC/exhaustion Cyanosis Peak flow <33% predicted Poor respiratory effort Normal or raised PaCO2
Features of ADHD
INATTENTION HYPERACTIVITY IMPULSIVENESS impaired concentration distractibility difficulty taking turns fidgety
Treatment for ADHD
CBT, methylphenidate (stimulant medicine - increase dopamine)
Side effects of methylphenidate
Dry mouth
Loss of appetite
Insomnia
Erythema multiforme and causes
Rash with target lesions
Penicillin, NSAIDs, phenytoin, HSV!
Name 2 complications of eczema
Cellulitis (gram positive cocci) - treat with flucloxacillin Eczema Herpeticum (herpes simplex) - acyclovir
Complications of chicken pox
Secondary bacterial infection - toxic shock syndrome
Encephalitis/cerebellitis
DIC
Purpura fulminans
What are Fraser guidelines used for
To give contraception to under 16s