Paediatrics Flashcards
1
Q
What routine immunisations are given to children 2 months old?
A
Ratovirus
6 in 1
Men B
2
Q
What routine immunisations are given to children 3 months old?
A
6 in 1
Rotavirus
Pneumococcal
3
Q
What routine immunisations are given to children 4 months old
A
6 in 1
Men B
4
Q
What routine immunisations are given to children between the ages of 12-13 months?
A
Haemophilius influenzae type B/Men C
MMR
Men B
Pneumococcal
5
Q
What routine immunisations can be given to children every year from the age of 2+ years, how is it administered?
A
Annual influenza- given via both nostrils
6
Q
What routine immunisations are given to children between 3 years and 4 months - 5 years?
A
4 in 1 (diphtheria, polio, pertussis, tetanus)
MMR
7
Q
What immunisations are given to children from the ages of 12-14 years age?
A
12-13 yrs- boys and girls offered the HPV
14- tetanus, diphtheria, polio (3 in 1) and Men ACWY
8
Q
What is the prophylaxis medication for bronchiolitis?
A
Palivizumab- only administered in high risk patients (premature infants, CHD)
Given as a monthly injection)
9
Q
What is a major complication of bronchiolitis?
A
Bronchiolitis obliterans- (aka popcorn lung) permanent obstruction of bronchioles due to chronic inflammation and resultant scar tissue formation.
Diagnosis is via CT scans, measure of lung function (significantly reduced FEV1)
10
Q
Name 3 RF and 5 Sx of bronchiolitis?
A
Rf- prematurity, winter months, CHD
Sx- Coryzal Sx and mild fever precedes, dry cough, wheezing, grunting, feeding difficulties w/ increasing dyspnoea, intercostal recession
11
Q
What is the most likely causative agent in pneumonia in children? What is the mx?
A
Strep pneumoniae
Mx-
1st line- amoxicillin
If no response add a Macrolides
12
Q
What age group is croup most prevalent in, and give 5 Sx?
A
6months - 3 years
Seal like barky cough
Fever
Stridor
Agitation
Coryzal Sx
13
Q
What routine vaccination in the UK has decreased the incidence of epiglottis in children?
A
Haemophilius influenzae B (HiB)
14
Q
Give 5sx of epiglottitis and the appropriate management?
A
Fever
Stridor
Muffled voice
Tripod position **
Drooling if saliva **
Dysphagia
Mx- secure airway
+IV abx, supplemental oxygen, corticosteroids
15
Q
What is the 1st line and Gs investigation for epiglottitis
A
1st line- lateral radiograph (thumb sign)
Gs- laryngoscope
16
Q
What is the management of acute asthma in children?
A
- supplemental oxygen if says <94%
- bronchodilators (stepwise approach)
—nebulised salbutamol
—nebulised ipratropium bromide
—Iv magnesium sulphate
—iv aminophyline - steroids
— po prednisalone
—iv hydrocortisone - abx if required
17
Q
When administrating high doses of salbutamol when mx acute asthma what should me monitored?
A
Monitor serum potassium-
Se of salbutamol- tachycardia and tremor
18
Q
What is the 3 grade severity of acute asthma?
A
Moderate-
PEFR >50%
Severe-
PEFR <50%, broken sentences, signs of rd
Life threatening
PEFR <33%
Exhaustion and poor reps effort
Altered consciousness
19
Q
Name 5 triggers of acute asthma?
A
Infection
Cold weather
Excercise
Allergens
Stress
Irritants
Food allergies
20
Q
Management of asthma in children under 5?
A
SABA
+low dose ICS or LTRA
+other option
Refer to asthma specialist
21
Q
Management of asthma in children 5-16?
A
SABA
+low dose ICS
+LTRA
stop LTRA and start LABA
Stop Ics/LABA and start MART regime (mart includes ICS)
Refer
22
Q
What is CF?
A
Autosomal recessive disorder characterised by genetic mutation of CFTR gene on chr 7
23
Q
What is the Ix for a diagnosis of CF?
A
1st line- new born screening (immunorecative trypsinogen test)- HEEL PRICK
GS- SWAET TEST >60mmol/l of chloride conc
24
Q
Give 5 signs and symptoms of CF?
A
FTT
Failure to pass meconium
Bilateral absence of vas deferens in males
Steatorrhoea
Recurrent resp infections
25
What is primary ciliary dyskinesia and what’s other condition is it strongly linked with?
PCD (aka kartangers syndrome) is an autosomal recessive condition that affects the cilia of various cells.
Strongly liked with SITUS INVERTUS
26
What is the GS ix of PCD and list 5 Sx?
Gs ix- nasal brushing/bronchoscopy
Sx
Paranasal sinusitis
Bronchiecstatsis
Subfertility
Situs invertus
Chronic cough
Recurrent infections
secretory otitis media
27
What is the causative agent in whooping cough?
Bordatella pertussis (gram-ve bacteria)
28
What is the management of whooping cough?
Inform PHE- pertsusis is a notifiable disease
Supportive care
Abx
- infant <1month- Macrolides e.g. azithromycin
- infant >1 month and children- Macrolides/trimethoprim
Prophylaxis abx to contacts-**Eyrthromycin**
29
What factors would support the diagnosis of a viral induced wheeze rather than asthma?
1. In children less than 3 years of age
2. No hx of atopy
3. Only occurs during viral infections
30
Gs Ix of whooping cough, and give 5 Sx?
Gs- culture of nasopharyngeal swab
Sx-
Whooping cough
Rhinorrhea
Post tussive emesis
Absent/low grade fever
Decreased appetite
31
What is laryngomalacia and give signs and symptoms, Ix, and mx?
Laryngomalacia is a congenital abnormality of the larynx, where supraglortic larynx results I. Upper airway obstruction
Inspiratory stridor (onset within 2 weeks of birth)- becomes worse if feeding, upset, lying in back
Normal cry
Feeding difficulties
Ix- GS- flexible laryngoscope (omega shape)
Mx- usually resolves as ageing
Tracheostomy (rare)
Surgery
32
What is the Ix for anaphylaxis?
Gs- Serum mast cell tryptase- measured within 6 hours of reaction
33
Management of anaphylaxis, give appropriate measure of adrenaline in each age group?
ABCDE assessment
IM adrenaline (repeat after t minutes if no improvement)
—< 6months- 100-150 mcg
— >6 months - 6 years- 150 mcg
— 6-12 years- 300mcg
— 12+- 500mcg
Antihistamines (chlamphenamine or certrizine)
Steroids- iv hydrocortisone
34
What is Kawasakis disease and list it’s criteria for diagnosis?
Kawasaki disease is a large vessel vasculitis.
Fever > 5 days and 4 more of the below symptoms
1) bilateral conjunctivitis
2) cervical lymphadenopathy
3) polymorphic rash
4) cracked lips/strawberry tongue
5) oedema / desquamation of hands/feet
35
What is the management for kawasakis?
High dose aspirin
Ivig
Echo
36
What is the investigation of choice to diagnose intersucception?
Uss- target sign/sausage shape in RUQ
37
List 4 symptoms of intussusception?
Blood stained stool ‘redcurrant jelly’ (late sign)
Episodic crying
Drawing legs towards chest and going pale
Vomiting
38
Mx of intussusception?
Reduction by air insufflation
39
What is the main cause of scarlets fever?
Group A strep
40
What is the features of scarlets fever?
Sandpaper rash (first appears on torso then spreads)
Strawberry tongue
Fever prior to rash for 1-2 days
41
Tx of scarlets fever?
Notifiable disease
Oral phenoxymethylpenicillin 10 days
children can return to school 24 hours after commencing abx
42
List the 4 features of TOF?
VSD
RV hypertrophy
RV outflow tract obstruction
Overriding aorta
43
What is meckels diverticulum?
A congenital diverticulum of small intestine. Remnant of omphalomesenteric duct
44
When should meckels diverticulum be suspected and what’s the choice of investigation?
In children <2 years with lower GI bleed
In stable children- Technetium scan
Unstable- MESENTERIC arteriography
45
Describe the murmur found in PDA?
Continuous ‘machienery’ murmur- loudest under left clavicle
46
What are the Sx of biliary atresia and what is the common findings on Ix?
Sx-n
Jaundice extending beyond 2 w physiological jaundice
Dark urine
Pale stools
Appetite and growth disturbances
Hepatomegaly
Ix-
Increase in liver transaminases (GGT ***)
Increase in conjugated bilirubin
47
What is the causative agent of hand foot and mouth?
Cocksackie a16
48
What is perthes disease?
Degenerative disease affecting the femoral head causing a vascular necrosis of femoral head
49
What are the finding of perthes disease on X-ray?
Widening of joint space
Decrease in femoral neadnsize- flattening
50
List the features that is supportive of a measles diagnosis?
Prodromal- irritable, conjunctivitis, fever
Koplik spots- white spots in buccal mucosa
Rash- starts behind ear
51
What is the main complication of measles?
Otitis media
Pneumonia (most common cause of death)
52
List the notifiable rashes to PHE?
Measles
Scarlet fever
Rubella
53
What is the formula for working out maintenance fluid requirement in children?
1st 10 kg of body weight at 100ml/kg/day
2nd 10 kg of body weight at 50ml/kg/day
Remaining body weight at 20ml/kg/day
MAX fluid for girls- 2000ml
MAX fluid for boys- 2500ml
54
What is the most common cause of an abdominal mass in children?
Wilm’s tumour (nephroblastoma)
Occurs in children <5
Does not cross midline
55
What is the rescue medication given to children who suffer from febrile convulsions?
Buccal midazolam
56
List 3 features of Down’s syndrome?
Epicanthic foods
Short neck and stature
Single palmar crease
57
List 3 features of trisomy 13?
Patau’s syndrome
Polydactyl
Microcephaly
Celt lip/palate
58
List 3 features of trisomy 18?
Edward’s syndrome (ROME)
Do not survive more than a few months
Rocker bottom feet
Overlapping 4th and 5th fingers
Microgranthia
Low ears
59
What is the most common causative organism for
A) croup
B) bronchiolitis
C) whooping cough
A) parainfluenzae virus
B) RSV
C) bordatella pertussis
60
What is the common organism responsible for roseola infantum and what’s the most common complication associated with this disease?
HHV6
Complication- febrile convulsions
61
What is the management of omphalocele and how does this differ from gastroschisis?
Gastroschisis- bowel protruding without sac- urgent surgery required
Omphalocele/exomphalos- bowel protruding with sac- staged closure starting immediately w/ completion at 6-12 months
62
What x ray findings are concurrent with NEC?
Pneumoperitoneum
Pneumatosis intestinalis
Dilated bowel loops
Bowel wall oedema
63
List the 5 features of innocent murmurs?
5s
Soft
Systolic
Short
Symptomless
Situation dependent- quieter on standing, only appearing on unwell children)
64
What is ebsteins anamoly and what causes it?
When the tricuspid valve in the RA is set lower near the apex therefore big RA and small RV
Exposure to lithium in utero **
65
What is syndrome is coarctation of the aorta associated with, and give Sx of CoA in children?
CoA associated with Turner’s Syndrome
Neonates- weak femoral pulses
Systolic murmur (loudest between the scapulae)
Gray and floppy baby
Radiofemoral delay
Ix- perform 4 limb BP
66
What is rheumatic fever?
An autoimmune disease that occurs after a group A strep throat infection that can affect joints, heart, brain and skin. Occurs 2-4 weeks after infection
A type 2 hypersensitivity reaction caused by group a beta haemolytic strep (strep pyogenes)
67
List 5 symptoms of rheumatic fever?
Joint pain
Erythema marginatum rash (pink rings on torso + prox limbs)
Chorea
Murmurs (pansystolic because mitral valve most affected)
Subcutaneous nodules
Fever
Recent throat infection/scarlet fever
68
What is the criteria used to diagnose rheumatic fever and it’s subsequent mx?
JONES CRITERIA (2 major or 1 major + 2 minor)
Major (JONES)- Joint arthritis, Organ inflammation, Nodules, Erythema marginatum, Syndeham chorea
Minor (FEAR) Fever, ECG changes, Arthralgia, Raised inflam markers
Ix- throat swab, ABO titre, Echo/ECG/CXR
Mx- treat strep infection- penicillin V for 10 days
69
What is TGA and explain the types?
When pulmonary artery and aorta swap positions.
There’s two types-
1) dTGA- where the aorta and pulmonary artery swap places so there’s 2 completely separate circulation systems
So RA—RV—Aorta—Body—RA…..
And LA—LV—PA—lungs—LA—LV…
No Sx in baby in utero but causes death on birth however can survive if PDA/VSD
2)lTGA- essentially where ventricles and associated valves swap places so essentially
RA—LV—PA—Lungs—LA—RV—Aorta—Body
Basically valves not built for the pressures so can cause RV hypertrophy —> HF
SX-
loud single s2
No murmur
Ventricular pulse
70
What are the 4 features of TOF?
Overriding aorta
VSD
Right ventricular hypertrophy
PV stenosis
71
Sx and mx of TOF?
Sx appear roughly 1-6 months and associated with trisomy 21, 18, 13, and digeorge
Harsh ejection systolic murmur
Cyanosis
Poor feeding
Tet spells
2-4 months- reduced consciousness, irritable, SOB
Toddlers- squat
Mx- neonates given prostaglandin infusion (maintains PDA)
72
List 3 causes of PDA?
Congenital rubella
Prematurity
Perinatal distress
73
Explain the pathophysiology of PDA?
In utero DA kept open by prostaglandin E2. At birth level of PE2 drop and lungs produce bradykinin which constricts PDA. Should disappear 3 weeks post birth
74
List 5 sx (+ type of murmur) and mx of PDA
SOB
Apnoea
Cyanosis- once eisenmengers syndrome
FTT
Gibson machinery murmur (loudest at left infraclavicular area)
Tx- indomethacin/ibuprofen +/- surgical ligation
75
What murmurs are associated with VSD and ASD, and what conditions are these both associated with/
VSD and ASD associated with FAS and T21
VSD- most common CHD- pansystolic murmur
ASD- ejection systolic murmur
76
Describe the rash associated with JIA?
Salmon pink rash
77
Give the features of nephrotic syndrome?
Oedema
High Proteinuria
Hypoalbuminaemia
Hyperlipidemia
78
What is the most common cause of nephrotic syndrome in children, give 3 symptoms and list it’s mx?
Minimal change disease- Often following an URTI
Sx- facial swelling/eye puffiness, frothy urine, fatigue
Ix- urine test, blood tests (albumin and cholesterol)
Mx- corticosteroids (prednisalone)
79
What is Toddlers diarrhoea and what is its management?
Toddlers diarrhoea is a common condition affecting young children between ages 6 months-5 years. It is characterised by frequent watery stools in otherwise healthy children.
Ms- lifestyle advice
- limiting the intake of sugar containing fluids and juices
- encouraging well balanced diet
Avoiding excessive intake of foods rich in sorbitol or fructose such as certain fruits and beverages
80
What is the first line laxative -described to children?
Movicol
81
What is the tx of treating an acute attack of abdominal migraine?
Low stimulus environment
Paracetamol
Ibuprofen
Sumitriptan
82
What is the prophylactic medication for abdominal migraines?
Pizotifen- needs to be withdrawn slowly
Propranolol
Cyrophetadine
Flunarizine
83
What is sandifer’s syndrome?
A rare condition causing brief episodes of abnormal movements associated with GOR in infants + torticolis (forceful contraction of neck muscles) and dystonia (rabnormal muscle contractions causing arching of back).
Condition tends to resolve as the reflux improves
84
List 5 causes of GOR in children?
Obesity
Neurological Disorder e.g. cp
Hiatal hernia
Exposure to smoke
Overfeeding
85
What is the mx of GOR/D?
1st line- reassure parents and offer advice
Small frequent meals, burping regularly, not over feeding, keeping baby upright after feeding
In more problematic cases
Thickened milk formula
Gravis on mixed with feeds
PPIs
Surgical fundopliction
86
What is the mx of gastroenteritis?
Immediately isolate patient to prevent spread
Children need to stay out of school for 48 hours after Sx hab]ve resolved
Conservatives mx
Antibiotics only in severe cases
Food poisoning is a notifiable disease
87
What is the triad of haemolytic uraemia syndrome?
Microangiopathic hameolytic anaemia
Thrombocytopenia
AKI
88
What is the main culprit in coeliacs disease?
Gliadin
89
List 5 Sx of coeliacs?
**FTT
Steatorrhora
Abdominal pain**
Diarrhoea
Short stature
**Dermatitis herpetiformis~**
Fatigue
Weight loss
90
What is the 1st line and gold standard Ix in coeliacs disease?
1st line- anti IgA-tTG antibodies, anti endometrial antibody, IgA-tTG levels
Gs-OGD- duodenal or jejunal biopsy (crypt hypertrophy, villous atrophy and intra epithelial lymphocytes
91
What genetic association is associated with coeliacs?
HLA-DQ2
92
What other congenital defect is a neonate with hypospadias at an increased risk of having?
Cryptoprchidism
93
What is crohns disease and list the 1st line and GS ix?
an IBD characterised by transmural inflammation of Gi tract
1st line- Faecal calprotectin
GS- OGD and colonscopy with biopsy
94
List the findings of endoscopy and histology in crohns?
Endoscopy: Deep ulcers +/- fistulae, skip lesions ('cobblestone appearance')
Biopsy- transmural inflammation, increased goblet cells, granuloma
95
what is the mx of crohns (acute and remission)
acute- 1st line- monotheraphy with glucocorticoids e.g. prednisolone
remission
1st line- azathioproine or mercaptopurine
2nd line- Methorexate, infliximab
96
What are the findings of UC on histology and colonscopy
colonscopy- continuous inflammation, loss of haustral markings, pseudopolyps
biopsy- loss of goblet cells, crypt abscess, inflammatory cells (lymphocytes)
97
What is the criteia used to assess severity in UC
Truelove and Witt's criteria
98
what is the tx of UC (acute and remisison)
acute:
1st line- topical/oral ASA e.g. mesalazine
2nd line- corticosteroids
remission
Aminosalicylate
azathioprine
mercaptopurine
99
is smoking damaging or protective in UC and crohns?
UC- smoking is protective
crohns- smoking is a RF
100
What condition is linked to UC?
Primary sclerosing cholangitis
101
lIst 2 signs of appendicitis?
Rovsings sign- palpation of Left illiac fossa cause pain in the RIF
Rebound tenderness and percussion tenderness (suggetsive of ruptured appendix)
102
what is the electrolyte findings in pyloric stenosis?
Hypochloraemic, hypokalemic metabolic alkalosis
103
What is pyloric stenosis and list the GS Ix and mx?
Pyloric stenosis is a condition resulting from the hypertrophy of the pyloric sphincter
Gs Ix- Abdominal USS
Mx- Laparoscopic Ramstedt's Pyloromyotomy
104
List 3 RF of Pyloric stenosis?
first born Male infant (6- 8 weeeks)
Prematurity
Fhx of pylorioc stenosis
Exposure to prostaglandins/erythromycin/macrolides
105
What is biliary atresia and list 5 sx
Biliary atresia is a rare consition where the bile ducts of an infant are progressively fibrosed and destroyed leading to conjugated hyperbillirubinaemia, liver failure and death
Neonatal jaundice (Extending beyond physiological 2 weeks)
Chalky white stools
FTT
Brusiisng
Hepatosplenomegaly
106
What is the 1st line and GS ix of biliary atresia?
1st line- Deranged LFTS (Raised conjugated billirubin)
gs- Cholanhgiography
107
What is the main complication of untreated jaundice in babies and list 5 sx?
Kernicterus- excess billurubin damaging the brain esp the basal ganglia
Abnormal muscle tone
Poor feeding
Lethargic
Seizures
Arching of back nad neck
High pitched crying
108
What is CMPA?
A type 1 hypersensitivity reaction to the protiens found in cow's milk and typically presents in the first 3 months of life in formula fed infants
109
What are two main types of protein in cows milk that are responsible for causing an allergic reaction in CMPAs?
1) Casein- primary protien in cow's milk
2) Whey (20%)
110
List 5 sx of CMPAs?
Regurgitation and vomiting
Diarrhoea
Urticaria
atopic eczema
colic sx- irritability, crying
Wheeze
chronic cough
FTT
111
What is the mx of CMPA?
1st line- Extensive Hydrolysed Formula (eHF milk)
2nd line- Amino acid formula (AAF)
112
What is kwashiorkor and list 5 sx?
kwashiorkor is a disease marked by severe protein malnutrition and bilateral extremity swelling
sx
bilateral pitting oedema
Hair discolouration
Dermatosis/ulceration
Malnutrition
Protuding belly
hepatomegaly
lethargic
113
What other condtions is strongly linked with Hirschprungs?
Neurofibramatosis
Downs syndrome
Waardenburg syndrome (pale blue eyes, hearing loss, patches of white skin and hair)
MEN II
114
What is contraindicated in patients w/ intussusception?
Rotavirus
115
What is Meckel's diverticulum?
A congenital diverticulum of the small intetsine, it is a remenant of the omphalomesenteric duct
116
what si the rule of 2s in meckels?
occurs in 2% of the population
it is 2 inches long
2 feet away from the ileocaecal valve
117
what is the features of nephrotic syndrome
Proteinuria (>3.5g/day)
Odema
Hypoalbuminaemia
(hyperlipidaemia)
118
what is minimal change disease, and list the appropriate mx?
Minimal change disease is the msot common form of nephrotic syndrome in childeren (characteriwsed by heavy proteinuria, oedema and hypoalbuminaemia)
mx- 1st line- corticosteroid theraphy + fluid restriction, low salt intake
119
what are the results of the renal biopsy in someone with minimal change disease?
Normal glomeruli on light microscopy
elctron microspoy will show fusion of podocytes and effacemnt of foot processes
120
what are the characteristics of nephritic syndrome?
Hameaturia
Oliguria
Proteinuria (<3g/day)
Fluid retention--> HTN
121
wlsit 5 causes of nephritic syndrome?
SLE
HSP
Anti- glomerular basement membrane (Goodpastures)
Post strep glomerulonephritis
Iga nephropathy (aka bergers disease)
Alports syndroem
122
how to do you diferentiate between PSGN and IgA nephropathy
IgA nephropathy- develops 1-2 days after URTI, occurs in young males, macroscopic haematuria. #9bipsy- IgA mesangial cells deposition)
PSGN-develops 1-2 weeks after urti, proteinuria
123
what are the finidngs in DKA?
glucose >11.0 mmol/L
Ph <7.3
Bicarb <15 mmol/L
Ketones > 3mmol
124
What are the key features in PKD?
Renal cysts
headaches
htn
abdo/flank pain
haematuria
125
What rx can be given to slow down the progressive nature of PKD?
Tolvaptan
126
Whta is the difference between ADPKD and ARPKD?
ADPKD- most common. More severe form and early onset.
ARPKD- aka infantile PKD. can cause oligohydramnios--> Potters seqiuence (renal agenesisn+ pulmonary hypoplasia)
127
What drugs should be stopped in AKI as it may worsen renal function?
NSAIDs
Aminoglycosides
ACE I
Angiotensis II Receptor Blockers
Diuretics
128
List 2 causes of testicular torison and list 3 sx?
causes- bell clapper deformity, trauma via sports
sx- absent cremasteric reflex, no pain relied when scrotum elevated, tetsicualr pain, high riding testicle
129
What is a hydrocele and list 3 sx?
a collection of fluid between the layers of the membrane (tunical vaginalis) that surrounds the testis or along the spermatic cord
sx- transilluminated , tetsicle palpable within hydrocele, soft and fluctuant, enlargement of scrotal mass following activity
130
What is hypospadias?
where the urethral meatus is abnormally dispalced to the ventral side of the penis
131
What is phimosis?
in which the foreskin of the penis is tight or constricted making it difficult/impossible to retract over head of penis (normal in kids under 3 and generally resolves on its own)
132
List 3 primary causes of nocturnal enuresis?
Overactive bladder
High fluid intake
Psychological distress
133
List 3 secondary causes of nocturnal enuresis?
T1DM
UTIs
Constipation
Maltreatment
134
What is CAH
An autosomal recessive disease whcih casues defect in the synthesis of steroid hormone 21 hydroxylase enzyme in the adrenal cortex
135
Expalain the pathophysiology of CAH
21 hydroxylase enzyme converts progesterone into aldosterone and cortisol.
progetserone is also converted into testosterone however this is not reliant on 21 hydroxylse enzyme
in CAH due to there being no/little 21 hydroxylase enyme no/little aldosterone or cortisol is prooduced so the excess progesterone gets converted into testosterone
:. HIGH TESTOSTERONE, LOW ALDOSTERONE AND LOW CORTISOL
136
Explain the CRH/ACTH hormone axis
HYpothalamus releases CRH which acts on the anterior pituitary. AP relaeases ACTH this acts on the adrenal glands.
in the adrenal glands cortex
Z. Glomerulosa -- Mineralocorticoids (aldosetrone)
Z. Fasicualta -- Glucocorticoids (Cortisol)
Z. Reticularis -- Androgens (DHEA)
137
What blood gas abnormalities is seen in severe CAH and whats its mx?
Hyponatraemia, Hypoglycaemia, Hyperkalaemia
mx- IV slaine + hydrocortisone
138
What IX are done for CAH
Hormone testing
ACTH simulation tets will confirm diagnosis
139
What is the mx of CAH?
Lifelong Fludrocortisone and hydrocortisone tx
140
What sx would a baby with severe CAH display
Poor feeding
vomiting
dehydration
arrythmia
ambiguous genitalia
141
In children with eczema, what areas are commonly affected in
a) Infants
b) Younger children
c) older children
a) face and trunk
b) extensor surfaces
c) flexor surfaces and creases of neck and face
142
What is the difference between SJS and Toxic epidermal necrolysis (TEN)?
SJS affects <10% of body surface whereas TEN is defiened as >30% of skin involvement
143
List the causative agent and school exclusion rules for the following rashes:
a) Chickenpox
b) Measles
c) Hand Foot and Mouth
d) Scarlet Fever
e) Rubella
f) Slapped cheek
g) Roseola Infantum
h) Impetigo
a) VZV (HHV3)- exclude until all lesions crusted over (typically 5 days after rash onset)
b) Measles virus- 4 days from onset of rash
c) Cocksackie A16- no exclusion
d) Group A strep- 24 hours after first dose of Abx
e) Rubella virus- 5 days after onset of rash
f) Parvovirus B19- No exclusion
g) HHV6- No exclusion
h) Staph aureus- until leisons crusted or 48 hours after ABx
144
What are the 4 rx that are given in the tretament of TB and list its corresponding SE?
Rifampicin- Red/orange urne
Isoniazid- Peripheral neuropathy
Pyrazinamide- Hepatitis/gout
Ethambutol- Optic neuritis
145
What medication is co-prescribed with isoniazid to prevent peripherla neuropathy?
Pyrodixine (vitamin B6)
146
List the findings of TB on a CXR?
Upper lobe cavitation
Bilateral hilar lymphadenopathy
147
What is the gold standard ix for a diagnois aof active TB?
Sputum culture
148
What is the tx of meningiocal septicaemia in children
a) <3 months
b) >3 months
a) IV amoxicillin + IV cefotaxime
b) IV cefotaxime/ceftriaxone
149
List the red flag features in the NICE traffic light system for fevers in children <5 years?
Pale/Mottled
Grunting
RR >60
Moderate or severe chest indrawing
Reduced Skin turgor
Fever >38 in age<3months
Looks ill to helath professional
150
list the rf for DDH
Female sex
Positive FHx
Breech
Oligohydramnios
Firstborn child
151
What is the inheritance patetrn of haemophillia A
X linked Recesisve (only affects males)
152
When should a child with hypospadias be treated?
Age 12 months
153
How may a older child with DDH present?
+VE trendelenburg sign
leg length discrepancy
154
What si the triad associated with congenital rubella syndrome
Deafness
blindness
chd
155
What is the tx for SUFE?
Surgery- internal fixation: typically a single cannulated screw placed in the centre of the epiphysis
156
What is the triad of fetures in shaken baby?
retinal haemorrhages
Subdural haematoma
encephalopathy
157
Describe the mx of neonatal hypoglycaemia
neonatal hypoglycaemia <2.6 mmol/L
if baby asyptomatic > Encourage feeds and monitor
if baby symptomatic > admit to NICU and give 10% dextrose
158
WHat heart defect is associated with fragile X
mitral valve prolapse
159
What is the most likely cause of worsening neurological function in a preemie?
Intraventricular haemorrhage
160
What kind of lymphadenopathy is associated in rubella infection?
Postauricular and suboccipital
161
Billous vomitting + double bubble sign on X-ray?
Duodenal atresia
162
What is the potential consequencedoes having parvovirus B19 during preganancy cause the foetus?
Hydrops Foetalis
163
What is reflex anoxic seizures?
Occurs when child is startled, causes child to go to plae, lose conciousness and may have musvle twitching. WIthin 30 secs heart retstarts and child becomes concious again
164
list 3 differences between syncope and seizures?
syncope-
prodrome includes lightheadedness, sweating blurring of vision
Return of conciousness shortly after
no prolonged post-itcal period
seizures
prodromes include aura, dejavu, jacksonian march etc
can last upto 5 mins or more
Prolonged post itcal period
165
What is Cerebral palsy?
a disorder of movement and posture sdue to non progressive lesions of the motor pathways in the developing brain
166
What is the fkey finding in spastic CP, and where is the lesion?
Hypertonia
Leison- UMN periventricular white matter
167
What is the fkey finding/s in dyskinetic CP, and where is the lesion?
Athethoid movement (slow writhing movements in distal extremeties)
lesion- Basal ganglia and substantia nigra
168
What is the fkey finding/s in ataxic CP, and where is the lesion?
cerebellar signs (DANISH)
Lesion- Cerebellum
169
What is the mainstay ix in CP
MRI Head
170
What are the non-motor problems associated with CP
Learning difficulties
Hearing problems
Squints
Epilepsy
171
What inheritance pattern is DMD or BMD?
X linked recessive
172
What is the 1st line and GS ix in DMD?
1ST LINE- Serum Creatne kinase levels- elevated
GS- Gentic analysis
173
List 3 signs of DMD in a child
waddling gait
pseudohypertrophy of calfs
Gowers sign- hand on knees to get up
174
What is the gs Ix and mx of orbital cellulitis?
GS- CT sinus and orbit with contrast
Admit to hospital for IV antibiotics
175
List causes of Microcytic anaemia
Thalasseaemia
Anaemia of chronic disease
IDA
Lead poisoning
Siderolastic aneamia
176
List the casues of normocytic anaemia
Anaemia of chronic disease
Aplastic anaemia
Acute blood loss
Haemolytic
Hypothyroidism
177
List the causes of macrocytic anaemia
Megaloblastic- B12 deficiency, Folate deficiency
Normoblastic- Liver disease, Alcohol, Hypothyroidism, Reticulocytotic, Drugs like azathioprine
178
List the common causes of anemia in infnacy?
Physiological anaemia of infancy (MC)
Anameia of rpematurity
Blood loss
Haemolysis (Haemolytic disease of newborn, Heriditary spherocytosis, G6PD deficiency)
Twin-twin trnasfusion
179
List 5 physical fetures of Downs syndrome?
*PROBLEMS*
Palpebral fissures
Round face
Occipital and nasal flattening
Brushfield spots/Bradycephaly
Low set ears
Epicanthic folds
Mouth open + Protuding tongue
Strabismus/Sandal gap deformity/Single palmar crease
180
What is fanconi's anaemia?
an autosomal recessive disorder that involves all three blood cell lines. It is the most common cause of inherited bone marrow failure characterised by pancytopenia.
181
What is the mode of inheritance and genetic muttaion in sickle cell disease?
Autosomal recessive
valine replaced glutamic acid on chr 11
182
List the features of fanconi anaemia?
Bone marow failure (Anaemia, Thrombocytopaenia, neutropaenia)
Short stature
Malformed thumbs and forearms
skin pigmentation
Hearing defects
183
What is the mode of inheritnace of G6PD?
X linked recessive
(low levels of G6PD -- low levels of NADPH = Low levels of Glutathione rectase)
184
What is the management of ITP
asymtomatic- often recovers on its own
active bleeding- depends on platelet count
<30,000- Corticosteroids and IVIG
<10,000- Plasma exchange
185
What is the prothrombin time and APTT results in VWDs?
Prothrombin- normal
APTT- Prolonged
186
What is the mx of VWDs-
Vasopressin analogue- DDAVP
187
What is the mode of inheritance in Haemophillia and what factor is deficient in
a) Haemophillia A
b) Haemophillia B
c) what is the PT and APTT time
X linked recessive
a) Factor 8
b) Factor 9
c) PT- normal
APTT- Prolonged
188
What is Acute Lymhoid leukaemia?
Clonal expansion of lymphoblasts in bone marrow, peripheral blood and extramedullary tissue
189
What is the most common brain tumour in children?
Astrocytoma
190
What histology finding can be seen in an asytrocytoma
Rosnethal fibres (corkscrew eosinophillic bundles)
191
What are the features of a nephroblastoma/wilms tumour?
Abdominal mass
Painless haematuria
Flank pain
Fever
192
What other condition is wilms tumour associated with?
Beckwith-Wiedemann syndrome
193
What is the GS ix for wilms tumour
Renal biopsy- small round blue cells may be seen on histology (not exclusive)
194
Where does a neuroblastoma arise from?
The tumour arises from neural crest tissue of the adrenal medulla (the most common site) and sympathetic nervous system.
195
What ix are done for a neuroblastoma?
raised urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels
calcification may be seen on abdominal xray
biopsy
196
What is the mode of inheritance and gene affected in a retinoblastoma?
MOI- Autosomal Dominant
Gene affected- RB1 on Chr 13
197
What are the features of retinoblastoma
Absence of red reflex- replaced by a white pupil (Leukocoria)
strabismus
Visual problems
198
What is the most common malignant childhood bone tumour?
Osteosarcoma
199
What are the following reuslts for ewings sarcoma
a) Bloods
b) Imaging
c) Bones it affects
a) Raised WCC, ESR, LDH. Low Hb
b) Onion skin appearance
c) Pelvis and long bones
200
What are the following reuslts for osteosarcoma
a) Bloods
b) Imaging
c) Bones it affects
a) May show raised ALP
b) Sunburst appearnce
c) Metaphyseal region of long bones
201
What is the most common benign bone tumour in children?
Osteochondroma
202
What is the newborn hearnig test test?
Otoacoustic emission test
203
What test shoukld be done if the otoacoustic emisiion test is abnormal?
Auditory Brainstem Repsonse test
204
In childeren who present with otitis media, what criteria should be met in order to prescribe immediate abx?
Sx more than 4 days or have not imporved
Systematically unwell
Immunocompromised
<2y with bilateral OM
Perforation +/or discharge
205
what abx are given for OM?
Amoxicillin 5-7 days
206
List 3 complications of OM?
Meningitis
Brain Abcess
Facial N palsy
207
What abx are prescribed in an upper UTI?
3rd gen cephalosporins e.g. cefalexin/co-amoxicalv
208
What abx are prescribed in an lower UTI?
trimethoprim/nitrofurantoin 3days
209
What additional ix should be done for kids <6 months who have presented witha uti?
USS within 6 weeks
210
What are the sx of an atypical UTI?
Poor urine flow
Abdo/bladder mass
Raised creatinine
Septicaemia
Failure to respond to abx within 48 hours
211
What is the modified centor criteria?
Age3-14 years
Fever >38
Absence of cough
Tonsillar exudates
Cervical lymphadenopathy
212
What is the FeverPAIN criteria
Fever in the last 24 hour
Pus on tonsils
Attend rpaidly (within 3 days or less)
Severly inflammed tonsils
No cough or coryza
213
List 5 complications of Down's syndrome
AVSD**, VSD, ASD, ToF
Glue ear
Myopia
Hypothyroidism
Atlantoaxial instability
ALL
Alzheimer's dementia
Subfertility
LD
214
List the mutation in fragile X
Trinucleotide CGG repeat on FMR1 gene (X linked recessive)
215
List features of Prader-willi syndrome and the defect?
Paternal deletion of chr 15
Insatiable hunger
Severe hypotonia
LD
Dysmorphic fetaures
216
List features of angelman syndrome and deletion?
Maternal deletion on Chr 15
Happy demeanour
Fascination with water
WWidely spaced teeth
217
The mutation and features of williams syndrome?
Microdeletion on Chr 7
Elfin like facies
Very friendly and scoaible
Starburst eyes
Supravalvular aortic stenosis
Wide mouth and widely spaced teeth
218
List features of noonan syndrome?
AD
Webebd neck
Pectus excavatum
Short
Pulmonary stenosis
219
List the features and mx of HSP?
IgA mediated small vessel vasculitis
Purpuric rash, classiclaly over buttocks and limb extensor surfaces
Abdo pain
Polyarthritis
Nephritic syndrome- Haematuria, Renal failure/AKI
Tx- Analgesia, Self limiting, monitor renal function and BP
220
When should a refferal for the following be made?
a- Unilateral undescended testes
b- Bilateral undescended testes
a- refer by 3 months if still undescended
b- should be reviewed within 24 hours by senior paediatrician
221
What hearing test should be conducted in
a- Newborn
b- Failed newborn test
c- <4 yrs
d- >4yrs
a- otoacoustic emission test
b- Brainstem auditory repsonse test
c- Distraction test
d- Pure tone audiometry
222
Choice of Ix in Cerebral palsy?
MRI Brain
223
List the features of simple and complex febril convulsions?
Simple
- <15 minutes
- Generalised seizure
Complex
- 15-30 minutes
- Focal Seizure
224
How should urine culture sample be procured in kids with UTI?
Clean catch
if not possible use urine collection pad
225
List 2 antenatal perinatal and postnatal causes of CP?
Antenatal- Maternal infections, HIE, Trauma during preganncy
Perinatal- Birth aphsyixa, Preterm
Postnatal- Mneingitis, Head trauma, Kernicterus
226
WHat is the pathanomic rash associated with pityriasis roseola?
HHV6/7
Coin sized herald patch --> Rash
(Cristhmas tree pattern)
227
How can you prevent NEC in preemies?
Encopurage breastfeeding
Delayed cord clamping
228
List the Mx of NEC?
Nil by mouth + NGT for decompression
Broad spectrum Abx
TPN, IV Fluids
Laparotomy
229
List sx of
a) ealry onset GBS
b) Late onset GBS
a) < 7 days- poor feeding, alethargy, Fever, resp distress, sepsis
b) >7 days- meningitis signs
230
Port wine stains are associated with what condition?
Sturge weber syndrome (increases risk of gluacoma and seizures)
231
WHen is the heel prick test doen and list 3 conditions tested?
Day 5-8
Tests for 9 conditions (MCADD, CF, Congenital Hypothyroidism, Phenylketonuria, Sickle cell)
232
List what ix may be doen in JIA?
ANAs (O)
RF (P)
ESR/CRP (increased)
233
List a complcitaion of JIA?
Anterior uveitis
234
What babaies are screened for DDH?
All babies breech at 36 weeks
Multi-pregnancy
1st degree raltaive with hip problems
235
What staging is used in perthes disease?
Cattheral staging
236
WHat criteria is used to diagnose septic arthritis and list?
KOCHER Criteria
Fevr >38
Raised ESR
Raised WCC
Non weight bearing
237
List 3 signs of IDA?
Atrophic glossitis
Angular stomatis
Kolinychia
238
What condition has to be ruled out in miniamal change disease?
Peri- Orbital cellulitis
239
List the signs of mastoiditis?
Protuding ear
Erythema behind ear
Urgent refferal to paediatrics and IV Abx
240
what is quinsy?
A rare complication of tonsilllitis. Peritonsillar abscess (HOT POTATO voice)
241
WHta chemo regime is used in Hodgkins lymphoma?
ABVD Chemo
Adriamycin (doxorubicin):
Bleomycin:
Vinblastine:
Dacarbazine
242
WHta chemo regime is used in non-Hodgkins lymphoma?
R-CHOP
Rituximab (R):
Cyclophosphamide (C):
Doxorubicin (H):
Vincristine (O):
Prednisone (P):
243
What prophylaxis abx is given to close contact in acute epiglottitis?
Rifampicin
244
What is the fluid calculation for a bolus?
10-20ml/Kg
0.9 % NaCl
245
What is infantile colic?
Unconsollable crying in an otherwise helathy baby usually resolves by 5 months
246
What procedures are done for the following?
a) Billiary Atresia
b) Pyloric Stenosis
c) Hirschprung's Disease
d) Malrotation
e) Volvulus
a) Kasai Procedure
b) Ramsteds Pyloromyotomy
c) Swensons Procedure
d) Laparotomy
e) Ladd's Procedure
247
What is Hirschprungs Disease?
Absence of parasympathetic ganglionic cells of the myenteric plexus in the distal bowel and rectum thus leading to lack of peristalsis and obstruction
248
What is Intussusception and most common site?
Telescoping of proximal bowel into distal segment
Ileocaecal valve
249
What conditions is intussusception associated with?
CF
Meckels
250
WHat is the xray findings in TGA?
Egg on a string heart (Narrowed mediastinum and cardiomegaly)
251
List the RF of TGA and TOF?
Congenital Rubella
Older maternal age
Maternal diabetes
Alcohol in pregnancy
252
List the CKD stages?
stage 1- >90
stage 2- 60-89
stage 3a- 45-59
stage 3b- 30-44
satge 4- 15-29
stage 5- <15
253
Cyanosis in the first 24 hours is indicative of what heard defect?
TGA
254
Within how many hours/days should a child with an acute exacerbation of asthma be folowed up with GP and list 3 points thats shoudl be discussed?
WIthin 48 hours
Review sx and check PEF
Chec inhaler technique
Consider stepping up tx
Address potentail triggers
Advice on recognisisng an asthma attack
255
The aim of asthma management is control of the disease. Complete control is defined as what?
No daytime symptoms.
No night-time waking due to asthma.
No need for rescue medication.
No asthma attacks.
No limitations on activity including exercise.
Normal lung function (FEV1 and/or PEF > 80% predicted or best).
256
When is the APGAR score assessed and what does it include?
Assessed at 1 minute and 5 minutes after birth
Assesses
**Appearance and colour
Respiratory efforts
Pulse
Grimace/Reflex irritability
Activity/Muscle tone**
257
An absent corenal reflex during NIPE can be indicative of what?
Retinoblastoma
Congenital catarats
Vitreous haemorrhage
Retinal detachment
258
Whjat dietary advice would ypu gove to someone with CF?
Ensure a high caloric high fat diet with pancreatic enzyme supplements with every meal
259
List the electrolyte abnormlaity associated with CAH?
Hyponatraemia
Hyperkalaemia
Hypoglycaemia
Metabolic acidosis
260
What si the inheritance patetrn oF CAH?
aUTOSOMAL RECESSIVE
261
IF Juvenile myoclonic epeilepsy is left untreated what condition can it progress to?
Generalsied Tonic clonic seizures
262
How often should kids on ritalin be minitored?
every 6 months
263
List 4 tests that could be done in DMD patients ?
Cretinine kinase level
Muscle biopsy
Genetic analysis
EMG
264
at what point in time does physiological jaundice
typicall recover in a preterma and term baby
preterm- within 21 days
term- within 14 days
265
List 3 types of causes for
a) Pathalogical jaundice
b) Physiological jaundice
c) Prolonged
a) Sepsis, Haemolytic disorders (ABO incompatibility, G6PD, H.Spherocytosis), Congenital TORCH infections
b) Breast milk, Dehydration, Polycythemia, Crigler Najjar
c) Biliary atresia, Nenoatal hepatitis, Hypothyroidism
266
WHta are the 2 tx options for jaundice in neonates?
Phototherapy
Exchange transfusion
267
Give 3 RF that may contribute to recurrent ear infcetions in kids?
Genetic predisposition
Age 6m-2Y
cleft palate
allergies
Resp infections
268
Expalin the importance of midle ear ventilation in kids
Middle ear ventilation is crucial for equalising pressure, preventing fluid buildup, and
maintaining optimal hearing.
In conditions like OME, impaired ventilation leads to
persistent fluid accumulation, impacting hearing function.
269
Noonan syndrome is asscoaite with what 2 types of cancer?
Leukaemia
Neuroblastoma
270
WHta is toddlers fravture?
Spiral fracture of the tibia
271
what is the mx in the following cases
a) boy 2 month old with UTI
b) girl 4 months old with lower UTI
C) girl 8 months with upper UTI
a) refer urgently to paeds (all kids below <3months) and IV coamoxicalv
b) Trimethoprim/Nitrofurnatoi for 3 dyas
c) Cefalaxin/Co-amoxiclav for 7-10 dyas
272
Whe should an USS be arranged for kids with UTIs?
1- Children with atypical UTI
2- During infection if child <6 months for recurrent UTIs
3- within 6 weeks of all kids >6m with recurrent infections
273
When should a DMSA scan be organised?
1. all children udner 3 years with atypical/recurrent UTIs
2. all childen 3y+ with recurrent UTIs
274
List 3 causes of conductive and sensorineural HL?
conductive- Ear wax buidup, Otitis media with effusion, Eustachian tube defect (Downs, cleft palate etc)
SN- Acoustic neuroma, Meningitis, HIE, Rubella, Head injury
275
List 5 signs of dehydration in children?
Sunken fontanelle
Reduced conciousness
Dry mucous membranes
CRT >2 seconds
Cold peripheries
Tachypnoea
Tachycardia
Reduces urine output
276
What causes Toxic Shock syndrome and list sx?
Toxin producing GAS or staph aureus
Fever >39
Hypotension
Diffuse erythemous macular rash
277
List 3 sx of mumps and 3 complications?
Caused by **paroxymyovirus**
Fever
Parotitis
Transient unilateral HL
comp- pancreatitis, orchiditis, encephalitis
278
List 2 complictaions of eczema?
Cellulitis- cuased by staph auresu. Treat with oral Flucloxacillin
Eczema Herpeticum- caused by HSV. treat with aciclovir
279
List the fetaures of DIGeorge syndrome?
CATCH-22 (Autosomal Dominant)
Cardiac- TOF/Interupted aortic arch
Abnormal Facies
Thymic Aplasia
Cleft palate
Hypoparathyroidism, Hypocalcaemia -> Convulsions
- Micro deletion on chr 22
280
List 3 deletion mutations?
DIgeorge
Williams
Cru de chat
281
What is precocious puberty?
The development of secondary sexual characteristics in
- girls <8y
- boys <9y
282
List 5 causes of stridor?
Laryngomalacia
Epiglottitis
Croup
Foreign body inhalation
Anaphylaxis
283
Give 2 genetic disorders that cause learning difficulties?
Fragile X
Downs
284
What is the findings of G6PD in a blood smear?
Heinz bodies and bite cells
285
List 5 causes of CP
Congenital malformations
Maternal infections (CMV, Rubella, Toxi
Birth asphyxia
Meningitis
Head trauma
Intraventricular haemorrhgaes
