Geriatrics Flashcards
What is the criteria for diagnosing postural hypotension?
A systolic drop of >20mmHg or diastolic drop >10 mmHg within 3 minutes of standing from a sitting position
What are the results on imaging of vascular dementia?
MRI- white matter hyperintensities
What is the characteristics of Alzheimer’s Disease histologically?
Characterised by beta amyloid depositions and neurofibrillary tangles composed of TAU proteins
What class of medications is contraindicated when prescribing sildenafil for erectile dysfunction?
Nitrates
What medication can be prescribed in postural hypotension although not regularly done?
Fludrocortisone or Midodrine (alpha 1 agonist)
List the 4 cardinal Sx of Parkinson’s disease?
Lead pipe rigidity
Bradykinesia
Pill rolling tremor (resting)
Postural instability
What factors should be assessed in frailty and what questionnaire can be utilised to help make a diagnosis?
Gait speed
self reported health
PRISMA-7 Questionnaire
What are the side effects of L dopa?
Postural hypotension
Nausea and vomiting
Side effect of MAO-B inhibitors?
Serotonin syndrome
What medications are used in the treatment of Parkinson’s disease?
L-dopa
Dopamine agonists (ropinorole, bromocriptine)
MAO-B inhibitors (seligline)
COMT inhibitors (talcapone)
What clinical score can be used to determine severity of frailty?
Rockwood
List the different types of laxative giving an example for each?
Stimulant — senna, basocodyl
Bulk forming— isphagula husk
Osmotic— macrogrol, lactulose\
Stool softener— docusate sodium
List 4 causes of postural hypotension
Medications
Dehydration
Adrenal insufficiency
Sepsis
What is osteoporosis
A systemic skeletal disease characterised by low bone mass and microarchitectural deterioration therefore increase in bone fragility and susceptibility to fractures
List three endocrine disease that contribute to osteoporosis
Cushings
Hyperthyroidism
Hyperparathyroidism
Male hypogonadism
Rf for osteoporosis
‘SHATTERED FAMILY’
Steroid use
Hyperthyroidism/Hyperparathyroidism
Alcohol and smoking
Thin (BMI <22)
Testosterone deficiency
Early menopause
Renal/liver failure
Erosive/inflammatory bone disease
Diabetes
Family Hx
What abnormal finding can be found in cross section of bone in osteoporosis
Fewer trabecular in spongy bone
Thinning of cortical bone
Widening Haversian canals
Gs Ix for osteoporosis and results
Dexa scan- t score of -2.5 or less
What 2 areas are commonly affected in osteoporosis that the dexa scan focuses on
Lumbar spine
hip
Hip
What is a t score
Standard deviation that is compared to gender matched young adult mean
What criteria are listed in the FRAX assessment tool
Sex Weight Height Previous fracture Corticosteroid use Current smoking Parent fractured hip Alcohol
Other than dexa scan what other Ix can be done in osteoporosis
X-ray of wrist, spine, hip- of fracture suspected MRI spine Bone profile- calcium, phosphate, alp Vit d levels TFTs
Tx for osteoporosis
Rx- lifestyle advise (stop smoking, diet, regular exercise)
1st line Rx- bisphosphoneates + vit d and calcium
2nd line- Desonumab, HRT, Teriparatide
What advice should be given for bisphosphonates
Take whole (swallow) with plenty water while standing or sitting on empty stomach at least 30 minutes beofre breakfast and saty upright after taking ~30 mins
What are the adverse effects of bisphosphonates?
oesophagitis
oesophageal ulcers
osteonecrosis of the jaw
What t score is indicative of osteopaenia
t score of -1 to -2.5
What t score is indicative of osteoporosis
t score of less than -2.5