Nephrology Flashcards

1
Q

List 3 RF for an AKI?

A

Drugs- ACEI/ARB/NSAIDs etc
Iodinated contrast agents w/in past week
CKD + other end organ failure
65+

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2
Q

List 3 pre-renal causes of an AKI?

A

Hypovolaemia secondary to D+V
Renal Artery stenosis
Sepsis

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3
Q

List 3 intrinsic causes of an AKI?

A

Glomerulonephritis
Acute tubular necrosis
Rhabdomyolysis
Tumour lysis syndrome

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4
Q

List 3 post-renal causes of an AKI?

A

BPH
Kidney stone in urethra or bladder
External compression of the urethra

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5
Q

What are the features of an AKI?

A

Reduced urine output (<0.5ml/kg/hour)
Pulmonary/peripheral oedema
Arrhythmias (electrolyte imbalances)
Features of uraemia (for example, pericarditis or encephalopathy)

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6
Q

What is the criteria for an AKI to be diagnosed?

A

Rise in serum creatinine of 26mmol/L or greater within 48 hours

A 50% increase in creatinine within 7 days

Fall in urine output <0.5ml/kg/hour greater than 6 hours

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7
Q

What 1st line Ix would you do in someone with suspected AKI?

A

U&Es
Urinalysis

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8
Q

What medications are safe to continue in AKI?

A

Warfarin
Aspirin 75mg
Beta Blockers
Paracetamol
Clopidogrel
Statin

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9
Q

What medications are not safe to continue in AKI?

A

NSAIDs
ACEI
ARBS
Aminoglycosides
Diuretics

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10
Q

What medications may need to be stopped due to an increased risk of toxicity (but doesn’t usually worsen AKI itself) ?

A

Metformin
Digoxin
Lithium

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11
Q

What is the triad associated with nephrotic syndrome?

A

Proteinuria (>3g/24hr)
Hypoalbuminaemia (>30g/L)
Oedema

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12
Q

List 4 causes of nephrotic syndrome?

A

Idiopathic

Primary causes:
Minimal Change disease
Focal Segmental Glomerulosclerosis (FSGS)
Membranous nephropathy

Secondary causes:
Diabetes mellitus
SLE
Amyloidosis
Drugs (Gold and NSAIDS)

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13
Q

What Ix would you carry out for diagnosing nephrotic syndrome?

A

Urine dipstick
MSU
Protein:creatinine ratio

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14
Q

What are the ECG findings in hyperkalaemia?

A

Tall Tented T waves
Loss of P wave
Broad QRS

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15
Q

What is the short term mx of hyperkalaemia?

A

Combined Insulin/dextrose infusion
Nebulised Salbutamol

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16
Q

What is the long term mx of hyperkalaemia?

A

Calcium Resonium (via enema or Po)
loop diuretics
Dialysis

17
Q

What are the possible sx in a -ve fluid balance patient?

A

Tachycardia
Hypotension
Oliguria
Sunken eyes and reduced skin turgor

18
Q

What are the possible sx in a +ve fluid balance patient?

A

Elevated JVP
Cackles
Ascites
Tachypnoea

19
Q

What is the mx of minimal change disease?

A

Oral steroids (prednisolone)

20
Q

What is the mx of minimal change disease in a patient who is unresponsive to steroids?

A

Cyclophosphamide

21
Q

What would a renal biopsy in a patient with minimal change in disease show?

A

Normal glomeruli on light microscopy

Electron microscopy shows fusion of podocytes and effacement of foot processes