oxytocics and tocolytics

Question 1

magnesium sulfate moa

Answer 1

antagonistic to Ca2+; functions at the extracellular and intracellular level, decreasing Ca2+ availability by blocking membrane and intracellular channels, decreasing myometrial contractility

Question 2

Mg sulfate maternal adverse effects

Answer 2

flushing, nausea, blurry vision, lethargy hypotension, and pulmonary edema; loss of reflexes is the first sign to lower dose

Question 3

Mg sulfate contraindications

Answer 3

myasthenia gravis and impaired renal function

Question 4

Mg sulfate fetal adverse effects

Answer 4

(controversial) decreased HR, respiratory suppression, decreased GI function, increased NICU admission and length of stay

Question 5

indomethacin moa

Answer 5

non-selective COX inhibitor, preventing prostaglandin production

Question 6

indomethacin maternal adverse effects

Answer 6

GI: n/v, reflux, gastritis

platelet dysfunction

Question 7

indomethacin fetal adverse effects

Answer 7

premature closure fo ductus arteriosus

Question 8

oxytocin MOA

Answer 8

binds to Gq receptor that activates PLC; PLC activates DAG and IP3 causing Ca2+ release from the SR/ER; DAG and Ca2+ increase PKC activity resulting in the contraction of muscle

Question 9

dinoprostone moa

Answer 9

PGE2 - blocks progesterone and cause a local inflammatory response; causes cervical ripening

Question 10

misoprostol moa

Answer 10

PGE1; blocks progesterone and causes a local inflammatory response

Question 11

carboprost tromethamine

Answer 11

15-methyl-PGF2