Drugs for BPH

Question 1

alpha-1 blockers

Answer 1

prazosin, alfuxosin, terazosin, doxazosin, tamsulosin, and silodosin

Question 2

alpha-1 blockers side effects

Answer 2

GI: xerostomia and nausea
eye: “floppy iris syndrome”
CNS - dizzy, somnolance, asthenia, insomnia

Question 3

alpha-1a specific blockers

Answer 3

tamsulosin and silodosin

Question 4

tamsulosin and silodosin adverse effects

Answer 4

abnormal ejaculation, dopamine and other neurotransmitter blockade

Question 5

tadalafil moa

Answer 5

inhibition of PDE-5 decreasing the breakdown of cGMP resulting in prolonged high levels of cGMP, resulting in sm. muscle relaxation

Question 6

tadalafil adverse effects

Answer 6

rare - optic neuropathy, retinal artery occlusion, hearing loss;
contraindicated with concurrent organic nitrates

Question 7

finasteride and dutasteride moa

Answer 7

inhibition of 5alpha reductase, blocking the conversion of T to DHT, preventing the DHT driven proliferation of the prostate
finasteride (type II 5-alpha reductase)
dutasteride (type I and II 5-alpha reductase)

Question 8

5-alpha reductase inhibitors adverse effects

Answer 8

erectile and ejaculation dysfunction, decreased libido, gynecomastia, decreased PSA, teratogenic (but not carried in semen)

Question 9

least useful alpha-1 blocker

Answer 9

prazosin due to its short duration of action