bladder and ovarian cancer

Question 1

carboplatin and cisplatin moa

Answer 1

forms DNA intrastrand cross links and adducts

Question 2

cyclophosphamide moa

Answer 2

pro-drug of active alkylating moiety

Question 3

doxorubicin moa

Answer 3

intercalator, free radical generators, topi II inhibitor

Question 4

mitomycin C moa

Answer 4

mono and bi-functional alkylating agent

Question 5

paclitaxel moa

Answer 5

microtubule stabilizer inhibiting depolymerization

Question 6

thiotepa moa

Answer 6

DNA alkylation by aziridine (hydrolysis of thiotepa yields 3 moieties) and intrastrand cross linking bu the remaining moiety, diethylenethiophosphoramide

Question 7

carboplatin adverse effects

Answer 7

myelosuppression, elevated enzymes, BUN, and creatinine

Question 8

cisplatin adverse effects

Answer 8

severe nephrotoxicity, ototoxicity, and myelosuppression

Question 9

cyclophosphamide adverse effects

Answer 9

hemorrhagic cystitis, secondary malignancies, pulmonary fibrosis, infertility

Question 10

doxorubicin adverse effects

Answer 10

CHG, hepatic disease, secondary malignancies, extavasational necrosis

Question 11

mitomycin C adverse effects

Answer 11

chemical cystitis, contact dermatitis, palmar and plantar erythemas, pulmonary infiltrates

Question 12

paclitaxel adverse effects

Answer 12

myelosuppression, myalgia, arthralgia

Question 13

thiotepa adverse effects

Answer 13

dysuria, urinary retention, chemical/hemorrhagic cystitis, renal dysfunction