Oxyhemoglobin/Oxymyoglobin Disassociation Curve.

Question 1

How/why Oxyhemoglobin/Oxymyoglobin Disassociation Curve is affected by pH

Answer 1

Decreased pH lowers Hb-O2 affinity; Results in a “rightward” shift of the curve; favors “offloading if O2 to the tissues

Question 2

How/why Oxyhemoglobin/Oxymyoglobin Disassociation Curve is affected by temperature

Answer 2

Increased blood temperature lowers Hb-O2 affinity; Results in a “rightward” shift of the curve

Question 3

How/why Oxyhemoglobin/Oxymyoglobin Disassociation Curve is affected by 2-3 DPG

Answer 3

May result in a “rightward” shift of the curve; during altitude exposure, not a major cause of rightward shift during exercise