Blood Transport. Flashcards

1
Q

How O2 is transported

A

: 99% bound to hemoglobin (Hb), Each g Hb can transport 1.34ml O2 (Max Saturation); Increased O2 delivery accomplished by increased cardiac output and redistribution of blood flow from inactive organs to working skeletal muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Males O2/L blood

A

150g Hb/L blood x 1.34ml O2/g Hb = 200 ml O2/L blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Females O2/L blood

A

130g Hb/L blood x 1.34ml O2/g Hb = 174 ml O2/L blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

OxyHb Dissociation Curve

A

Deoxyhemoglobin + O2 < > Oxyhemoglobin; Direction of reaction depends on: PO2 of the blood and affinity between Hb and O2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

OxyHb Dissociation Curve at Lung

A

High PO2, Formation of OxyHb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

OxyHb Dissociation Curve at Tissues

A

Low PO2, Release if O2 to tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

OxyMb Dissociation Curve

A

Shuttles O2 from the cell membrane to the mitochondria

Mb has a higher affinity for O2 than hemoglobin, even at low PO2, allows Mb to store O2 (O2 reserve for muscles)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When PaO2 drops below 60 mmHg in OxyMb Dissociation Curve

A

Myoglobin has a higher affinity for oxygen than does hemoglobin
This allows for a unidirectional transfer of O2 from hemoglobin (blood) to the myoglobin (muscle fiber)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How CO2 is transported

A

issolved in plasma (10%), Bound to Hb (20%), Bicarbonate (70%); CO2 + H2O > Carbonic Anhydrase > H2CO3 > H+ + HCO3-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How CO2 is transported at Lung

A

O2 binds to Hb (drives off H+), Reaction reverses to release CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How CO2 is transported at Tissue

A

H binds to Hb, HCO3- diffuses out of RBC into plasma, Cl- diffuses into RBC (chloride shift)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly