Blood Transport.

Question 1

How O2 is transported

Answer 1

: 99% bound to hemoglobin (Hb), Each g Hb can transport 1.34ml O2 (Max Saturation); Increased O2 delivery accomplished by increased cardiac output and redistribution of blood flow from inactive organs to working skeletal muscles

Question 2

Males O2/L blood

Answer 2

150g Hb/L blood x 1.34ml O2/g Hb = 200 ml O2/L blood

Question 3

Females O2/L blood

Answer 3

130g Hb/L blood x 1.34ml O2/g Hb = 174 ml O2/L blood

Question 4

OxyHb Dissociation Curve

Answer 4

Deoxyhemoglobin + O2 < > Oxyhemoglobin; Direction of reaction depends on: PO2 of the blood and affinity between Hb and O2

Question 5

OxyHb Dissociation Curve at Lung

Answer 5

High PO2, Formation of OxyHb

Question 6

OxyHb Dissociation Curve at Tissues

Answer 6

Low PO2, Release if O2 to tissues

Question 7

OxyMb Dissociation Curve

Answer 7

Shuttles O2 from the cell membrane to the mitochondria

Mb has a higher affinity for O2 than hemoglobin, even at low PO2, allows Mb to store O2 (O2 reserve for muscles)

Question 8

When PaO2 drops below 60 mmHg in OxyMb Dissociation Curve

Answer 8

Myoglobin has a higher affinity for oxygen than does hemoglobin
This allows for a unidirectional transfer of O2 from hemoglobin (blood) to the myoglobin (muscle fiber)

Question 9

How CO2 is transported

Answer 9

issolved in plasma (10%), Bound to Hb (20%), Bicarbonate (70%); CO2 + H2O > Carbonic Anhydrase > H2CO3 > H+ + HCO3-

Question 10

How CO2 is transported at Lung

Answer 10

O2 binds to Hb (drives off H+), Reaction reverses to release CO2

Question 11

How CO2 is transported at Tissue

Answer 11

H binds to Hb, HCO3- diffuses out of RBC into plasma, Cl- diffuses into RBC (chloride shift)