Long Term Regulation of Arterial Blood Pressure. Flashcards
Kidneys (via control of blood volume): Important site of synthesis for several hormones including:
Renin, Erythropoietin, 1,25-dihydroxyvitamin D3 (calcitriol)
Renin
Na+ and H2O balance
Erythropoietin
Erythrocyte Formation
1,25-dihydroxyvitamin D3 (calcitriol)
Ca2+ homeostasis
Renin-Angiotensin-Aldosterone-Antidiuretic Hormone System
Angiotensinogen> Renin comes in> Angiotensin I> Converting Enzyme comes in> Angiotensin II> Stimulation of aldosterone secretion> Increased Preload (If Angiotensin II does not stimulate aldosterone, afterload is increased)
Location of Osmoreceptors
Hypothalamus and Macula Densa; Afferents for the Renin-Angiotensin-Aldosterone System
Hypothalamus Osmoreceptors
Plasma osm increases cause osmR>
Macula Densa Osmoreceptors
Cell cluster in Kidney (distal tubule); Affererently to Macula densa (Increase PGI); PGI signal juxtaglomerular apparatus (kidney): Increase Renin; RAAAS system now active