Oxygen Therapy Flashcards
Why is oxygen needed for survival?
for energy
- oxidative phosphorylation
Glucose + O2 > CO2 +H2O + 38 ATP
What is anoxia?
no oxygen availability in tissues
HYpoxia?
lack of oxygen availability in tissues
Hypoxemia?
lack of oxygen in the blood
What is FiO2?
fraction of O2 in inspired gas
Note: we normally breathe in 21%
What are the FiO2 percentages in 1 to 6 liters?
1 L\min = 24%
2 L\min = 28%
3 L\min = 32%
4 L\min = 36%
5 L\min = 40%
6 L\min = 44%
What are the normal SaO2 values?
95 - 100%
Normal PaO2 values?
arterial blood - 75-100 mmHg
What is oxygen therapy?
the administration of oxygen at concentrations greater than that in room air to treat or prevent hypoxia
Is oxygen a drug?
yes
Clinical goal of O2 therapy?
- Treat hypoxia
- Decrease work of breathing
- Decrease myocardial work
What are the types of hypoxia?
- Hypoxic hypoxia
- Anemic Hypoxia
- Stagnant hypoxia
- Histotoxic hypoxia
What is hypoxic hypoxia?
when your tissues don’t get enough oxygen
Causes of hypoxic hypoxia?
- O2 poor air, hypoxic gas mixture
- High altitude
- Hypoventilation
- Shunts – septal defects
- Diffusion defects – pneumonia, lobar collapse
What is anemic hypoxia?
Oxygen carrying capacity of blood is decreased
Causes of anemic hypoxia?
- Anemia
- Altered Hemoglobin: CO Poisoning
Describe how CO poisoning causes anemic hypoxia?
- CO reacts with oxygen, creating carboxy hemoglobin, which leads to tissue hypoxia.
- In the case of toxic concentration, increases in carboxyhemoglobin interfere with gas exchange in respiratory system, resulting in hypoxemia.
What is stagnant hypoxia?
inadequate tissue perfusion
Causes of generalized stagnant hypoxia?
- Hypovolemia
- Mitral Stenosis
- Constrictive pericarditis
- Myocardial ischemia
NB - all the above conditions reduce the perfusion of organs by reducing the amount of blood that gets to them
Causes of localized hypoperfusion stagnant hypoxia?
- Arterial obstruction
- thrombus
- oedema
NB - in this instant there is a certain area that is not being perfused due to the reasons above
Qhat is histotoxic hypoxia?
cells cant utilize the oxygen
Causes of histotoxic hypoxia?
Electron transfer system of cytochrome oxidase is paralyzed
E.g. cyanide poisoning
How does cyanide poisoning cause histotoxic hypoxia?
- Cyanide is a potent cytochrome c oxidase (COX, a.k.a. Complex IV) inhibitor
- As such, cyanide poisoning is a form of histotoxic hypoxia, because it interferes with oxidative phosphorylation
Types of hypoxia that benefit from O2 therapy?
- hypoxia
- anemic
- stagnant