Ovarian Pathology Flashcards
What is the order of follicle formation
Primordial follicle
Primary Follicle
Secondary follicle
Graafian Follicles
Ovulation
Corpus Luteum
Corpus Albican
What are the 3 characteristics of an ovarian cyst
Thin, smooth walls
Anechoic
Posterior enhancement
Maj11ority of ovarian masses are
Simple cysts
What are functional ovarian cysts
Benign, cystic masses that respond to cyclic hormonal stimulation
What is the most common cause of ovarian enlargement in young women
Functional ovarian cysts
What are the 3 types of functional cysts
Follicular cyst
Corpus luteum cyst
Theca-lutein cyst
True or False
Functional cysts regress by themselves without any type of intervention
True
Fluid accumulation in the posterior cul-de-sac is due to
Physiology
What are the complex cystic masses (Benign ovarian neoplasm)
Serous cystadenoma
Mucinous cystadenoma
Brener tumor
Dermoid cyst
Fibroma
Endometrioma
Theca lutein cysts happen
Bilaterally
What is the most common type of ovarian cyst
Follicular cyst
Follicular cysts occur when a
Dominant follicle fails to ovulate and remains mature
Signs and symptoms of follicular cyst
Asymptomatic
Dull adnexal pressure
Fullness/bloating
Pain on side of cyst
May lead to menstrual irregularities
Surgery may be needed
True or False
Follicular cysts are smaller than dominant follicles
False - Larger than
Follicular cysts can be become ___ and can ___
Large and can rupture
What is the sonographic apperance of follicular cysts uni or bi
Unilateral
What are the risk factors for follicular cysts
Women of reproductive age
What are the differentials of follicular cysts
What are they?
Serous cystadenoma:
Epithelial tumor
Hydrosalpinx:
Fluid-filled fallopian tube
Type of functional ovarian cyst that occurs when corpus luteum fails to regress
How long do they last?
Corpus luteum cysts
14 days
What would happen to corpus luteum cyst if pregnancy occurs
Produces progesterone and will sustain the early stage of pregnancy, becomes corpus luteum of pregnancy
What is the most common pelvic mass encountered during 1st trimester of pregnancy
Corpus luteum cyst
True or False
Corpus luteum does not always indicate pregnancy
True
How does a corpus luteum cyst of menstruation forms from
Normal 2-3 cm dominant cyst/Graafian follicle ruptures
As corpus luteum cyst of menstruation regresses it becomes
Corpus albicans
Internal hemorrhage occurs into functional cysts of the ovary
Occurs most commonly in
Hemorrhagic corpus luteum cyst
Corpus luteum cyst
What are the signs and symptoms of a hemorrhagic corpus luteum cyst
Asymptomatic
Pelvic pain
Enlarged and tender ovary
Irregular menstrual cycle
Nausea/vomiting
What are the sonographic findings of corpus luteum cyst
Anechoic
Unilateral
Fluid in cul-de-sac or adjacent to ovary
Ovarian artieral flow-low resistant pattern
If a hemorrhage occurs with a corpus luteum cyst it will have what type of apperance
Fishnet apperance
Produces progesterone to support early pregnancy maintaining the decidualized endometrium
Corpus luteum of pregnancy
Sonographic apperance of corpus luteum of pregnancy - uni or bi
Unilateral
Caused by high levels of hormone, human chorionic gonadotropin
Theca Lutein cyst
Theca lutein cyst is a large ____
Functional cyst
Theca lutein cyst is associated with
Gestational trophoblastic disease
Normal pregnancy
Infertility drugs
Occurs when a sperm cell fertilizes an empty egg or 2 sperm cells fertilize normal egg cell
Gestational trophoblastic disease
What are the sonographic findings of theca lutein cyst
Bilateral
Multiloculated
Very large
Complications with hemorrhage, rupture, or torsion
Post surgical residual
Ovarian remnant syndrome
What are the signs and symptoms of ovarian remnant syndrome
Pelvic pain
Pelvic mass
Absence of menopause after oophorectomy
What is the sonographic apperance of ovarian remnant syndrome
Simple to complex
Thin rim
Free fluid
Paraovarian cysts arise from
Gartner’s duct remnant or Hydatid of Morgagni
Paraovarian cysts are most commonly found within the
Lies ___ to ovary and is separate from ___
Is a non___ cyst
Broad ligaments
Lies adjacent to ovary, separate from ovary
Non-functional cyst
What are sonographic findings of paraovarian cyst
Thin walled
Anechoic
Posterior enhancement
Small to 15 cm
Predominantly in patients with a history of previous abdominal surgery
Peritoneal inclusion cyst
Peritoneal inclusion cyst is a result of
Trauma
PID
Endometriosis
In peritoneal inclusion cysts if peritoneal adhesions present with accumulation of fluid it will
Entrapped in ovaries
What is the main source of peritoneal fluid in women
Ovaries
What is the sonographic apperance of peritoneal inclusion cyst
Anechoic fluids may containing echoes
Fluid & septations surround an intact ovary
Development of uterine’s inner lining tissue outside of the uterus
Endometriosis
Endometriosis is found in which 2 cavities
Abdominal and pelvic
What are the main symptoms of endometriosis
Pain
Menstrual irregularities w/ excessive bleeding
Bloating/nausea
Infertility
Dysmenorrhea
Painful period
Dyspareunia
Pain during intercourse
What are the causes of endometriosis
Retrograde menstruation
Surgical scar implantation
Immune system disorder
What are the risk factors of endometriosis
Never giving birth
Menses at early age
High levels of estrogen
1+ relative with endometriosis
What are the treatment options of endometriosis
Hormones
Excision surgery
Endometrioma is also known as
Chocolate cyst
Cystic mass filled with blood in the ovary as
Endometrioma or chocolate cyst
Endometriomas are a result of
Localized endometriosis
Endometriomas are most common in
Women of reproductive age
Endometriomas may be classified as what 2 types
Diffuse or localized
Most common form of endometriosis
Diffuse endometriosis
Endometrial tissue on one or both ovaries
Localized endometriosis
In endometrioma the ovarian tissue may be
Partially or completely replaces by endometrial tissue
Internal content of endometrioma may consist of
Old blood
Fresh
Hemorrhage
Clots
What are the signs and symptoms of endometriomas
Dysmenorrhea
Dyspareunia
Metromenorrhagia
Infertility
What is the sonographic apperance of endometriomas
Well defined
Homeogenous
Thought to represent cholesterol deposits
Ovarian torsion is also known as
Adnexal torsion or tubo-ovarian torsion
Partial or complete rotation of the ovarian pedicle on its axis
Ovarian torsion
Mobile adnexal structures allow torsion at the
Mososalpinx
In ovarian torsion there is a decrease in
Lymphatic and venous drainage
Ovarian torsion has the rotation of the ___ and portion of the ___ on supplying ___ pedicle
Ovary, fallopian tube, vascular
For ovarian torsion has eventual loss of ___ perfusion and results in ___
Loss of arterial perfusion
Results in infraction
Clinical findings of ovarian torsion
Sudden or severe pelvic pain
Nausea/vomiting
Palpable adnexal mass & tenderness
Surgical emergency
What are the lab values of ovarian torsion
Elevated WBC
The sonographic findings of ovarian torsion is variable on:
Variable on:
Duration
Degree
Existence of mass
Other sonographic findings of ovarian torsion
Peripherally displaced follicles with hyperechoic central stroma
Free pelvic fluid
Ovary tender to transducer
What are the Doppler findings of ovarian torsion
Decrease/absent blood flow
Absent/reversed diastolic flow
Whirlpool sign
Poly-cystic ovary syndrome is also known as
Stein-leventhal syndrome
A complex endocrinologic disorder resulting in oligomenorrhea and chronic anovulation
Polycystic ovary syndrome
In polycystic ovary syndrome there is an imbalance in:
Resulting from:
LH & FSH
Due to abnormal estrogen and androgen production
PCOS will have follicles but they may fail to
Regulary release eggs
PCOS is most common in
PCOS is most common cause of
Women age 20-30
Infertility
Signs and symptoms of PCOS
Polycystic & enlarged ovaries
Infertility
Oligomenorrhea or amenorrhea
Hirsutism
Excess facial and body hair androgenism
Hirsutism
Sonographic apperance of PCOS
Enlarged ovaries (> 10 cubic cm)
Multiple, small, peripheral follicles
Bilateral
12+ follicles (2-9mm)
In PCOS the follicles located peripherally are known as the
String of perals
Equation to calculate ovarian volume
0.5 x L x W x Thickness of ovary
Cystic teratoma is also known as
Dermoid cyst
Dermoid is composed of
Dermal and epidermal elements
Termatomas composed of
Mesodermal and endodermal
Cystic teratoma is most common in
Is the most common
Most common site is
Common in young women of repro age
Most common benign tumor
Site is level of superior to the uteruine fundus
75% of all dermoid cyst are
Unilateral
Germ cell that is retained within the egg sac
Cystic teratoma
Cystic teratoma is filled with
Sebaceous material of hair, teeth, bone, thyroid, fibrous tissue and fluid
What are the clinical findings of cystic termatoma
Mild-acute abdominal pain
Adnexal fullness
Pressure-like symptoms
Sonographic findings of cystic termatoma
Posterior shadowing
“Tip of iceberg”
Cystic to complex
Common solid masses
Solid teratoma
Brenner tumor
Fibroma
Dysgerminoma
Thecoma
Rare, malignant, mainly in children and young adults
Solid teratoma
Sono findings of solid teratoma
Unilateral
Poor prognosis
Brenner tumor is also known as
Most common in
May be associated with
Transitional cell carcinoma
Postmenopausal women (50-60)
Meig’s syndrome
Meig’s syndrome
Ascities and pleural effusion
Clinical findings of Brenner tumor
Asymptomatic and found incidentally
Solid, abnormal growth on the ovary
Brenner tumor
Most Brenner tumors are ___
5% are ___
Benign
5% are malignant
What are the sonographic findings of Brenner tumor
Solid
Confused with pendunculated fibroids
Hypoechoic
50% calcifications
Unilateral (Can be bilateral)
Small
Equal to or >10cm
Benign ovarian tumor of sex cords
Ovarian fibroma
Fibromas arise from
Stroma and sex cords
90% of fibromas are ___
Big as ___cm
Mainly found in
Most common tumor associated with
Unilateral
25cm
Postmenopausal or perimenopausal women (50-60)
Meig’s syndrome
Clinical findings of fibroma
Small - Asymptomatic
Large - Pelvic pain
Pressure symptoms
Abdominal enlargement
Sono findings of fibroma
Solid
Hyperechoic
Have torsion
Rare maligant tumor and 75% occur between 10-30 years of age
Dysgerminoma
Symptoms of dysgerminoma
90% __
Pelvic pain
Irregular vaginal bleeding
Unilateral
Sono findings of dysgerminoma
Solid
Homogenous
Poor prognosis
Thecoma is also known as
Are uni or bi
Most common in
Theca cell tumor
Unilateral
Menopausal or postemenopausal women
Malignant thecomas are
Rare
Clinical symptoms of thecoma
Pelvic pain
Pressure symptoms
Sono findings of thecoma
Posterior shadowing
Foci or calcifications
Necrosis
Cystic degeneration
Common adnexal masses
Cystadenoma (Serous & Mucinous)
Cystadenocarcinoma (Serous & Mucinous)
Brenner Tumor
Granulosa cell tumor
Benign ovarian cystic tumor lined by a serous epithelium
Serous cystadenoma
Most common epithelial tumor
Serous cystadenoma
Second most common benign tumor of the ovary
Serous cystadenoma
Serous cystadenoma has peak incidence in the
4th & 5th decades
Signs and symptoms of serous cystadenoma
Nausea/vomiting/bloating
Fatigue
Low abdominal pain/pressure
Sono findings of serous cystadenoma
Papillary projections
Unilateral
Treatment for serous cystadenoma
Surgical excised
Most common type of ovarian cancer
Serous cystadenocarcinoma
Clinical manifestations of serous cystadenocarcinoma
Pain
Abdominal distension
Bowel obstruction
Nausea/vomiting
Easy satiety
Cachexia
Sono findings of serous cystadenocarcinoma
Papillary projection
Thick septations
Irregular borders
Components and septations demonstrate blood flow
Second most common epithelia tumor
Benign or malignant
Mucinous cystadenoma
Benign
Signs and symptoms of mucinous cystadenoma
Increase abdominal girth
Pelvic pressure
Bloating
Sono findings of mucinous cystadenoma
Large
Low-level echoes
Thin septations
Unilateral
Second most common epithelial ovarian cancer
Most common in
Mucinous cystadenocarcinoma
Menopausal women
What are the clinical findings of mucinous cystadenocarcinoma
Pelvic pressure
Bloating
Sono findings of mucinous cystadenocarcinoma
Similar to serous cystadenocarcinomas
Rare type of ovarian cancer
Most common in
Uni or Bi
Granulosa cell tumor
Adults
Unilateral
Most common sex cord-stromal tumor
Granulosa cell tumor
Granulosa cell tumor does what to women
Higher than normal levels of estrogen
Symptoms of granulosa cell tumor
Irregular menstruation cycles
Treatment for for granulosa cell tumor
Fertility-sparing surgery
Metastatic disease can affect the ovary from
Breast
GI Tract
Lymphatic spread
Other pelvic organs
Metastatic malignancy of the ovary from stomach, biliary tract, GB, pancreas
Krukenberg tumors
Sono findings of metastatic disease
Bilateral
Ascites
Complex
Necrotic
Solic
Hypoechoic
Types of inflammatory Diseases
PID
Pyosalpinx
Hydrosalpinx
Chronic salpinitis
Tubo-ovarian abscess
Peritonitis
2 types of PID consequences
Gonorrheal
Nongonorrheal
Nongonorrheal PID consequences result from retained products of
Conception
Appendicitis
Sigmoiditis
Prolonged use of IUD
PID may lead to
Parametritis
Chronic PID
Widespread fibrosis and adhensions
Associated with PID and use of IUD
Actinomycosis
Conditions that mimic PID
Endometriosis
Ectopic pregnancy
Hemorrhagic cyst
Multicystic ovarian disease
Clinical findings of PID
Fever
Leukocystosis
Rapid pulse rate
Vaginal discharge
For PID sonographically you always look for
Peristalsis
Inflammation of the fallopian tube that fills and swells with pus
Pyosalpinx
Acute pyosalpinx is shaped like a
Sausage
Clinical findings of pyosalpinx
Fever
Pelvic pain
Dyspareunia
Lab values of pyosalpinx
Leukocytosis
Sonographic findings of pyosalpinx
Distended fallopian tubes
Post reabsorption of the inflammation the tube becomes weak and thin
Hydrosalpinx
Clinical findings of hydrosalpinx
bhCG titers will prove difference
Colicky pain
Sono findings of hydrosalpinx
Anechoic fluid filled
Sausage-shaped
Beads of string sign
Adnesions and fibrosis may involve the peritoneal surfaces and bowel
Chronic salpingitis
Clincial findings of chronic salpinitis
Painful defecation
Dyspareunia
Intermenstrual pain
Hysterosalpingoraphy
Purulent material spills from Fallopian tube to the ovary
Tubo-ovarian abscess
Tubo-ovarian abscess is one of many later complications of
PID
Tubo-ovarian abscess can be life-threatening if the abscess
Ruptures and results in sepsis
Consists of encapsulated or confined pocket of pus with defined boundaries that forms during an infection of a fallopian tube and ovary
Tubo-ovarian abscess
Clinical findings of tubo-ovarian cyst
Nausea/vomiting
Abdominal & pelvic pain
Fever/chills
RUQ pain
Right sided pleuritic pain
Fitz-hugh-curtis syndrome
RUQ pain, right sided pleuritic pain
Lab values associated with tubo-ovarian abscess
High ESR
Sono findings of tubo-ovarian abscess
Local areas of tubal distention with pus and debris
Multiple loculations
Septation
Difficult to identitfy ovary
Inflammation of peritoneum
Peritonitis
Peritoneum covers and supports most
Abdominal organs
Peritonitis usually caused by
Infection from bacteria or fungi
What can happen if peritonitis is left untreated
Spread into blood (Sepsis) and to other organs
Peritonitis results in multiple
Organ failure and death
First symptoms of peritonitis
Poor appetite
Nausea
Dull abdominal ache
Other signs and symptoms related to peritonitis
Abdominal tenderness/distension
Chills/fever
Fluid in abdomen
Not/less passing urine
Difficult to pass gas/bowel movement
Vomiting