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Principles of Disease > Outline of Disease Process > Flashcards

Outline of Disease Process Flashcards

1
Q

Staging in cancer

A

Initiation
Promotion
Progression

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2
Q

Initiation

A

Chemical
Viral
Physical

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3
Q

Promotion

A

Growth factors

Oncogenes (positive regulators of growth)

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4
Q

Progression

A

Metastasis - tumour invades through basement membrane, moves into ECM/connective tissue/surrounding cells
Invaded blood vessels

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5
Q

Immunotherapy

A

Cancer cells can “hide” from T cells -
PD1 present on T lymphocytes
PDL-1 on tumour cells (LIGAND)
Interaction suppresses T cell action

Therapeutically block one to allow T cells to detect tumour

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6
Q

Physical initiation

A

Radiation
Oncogene activation
Gene amplification
Chromosome translocation

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Principles of Disease (15 decks)

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