Chemotherapy Flashcards
1
Q
Anti-cancer therapeutics
A
Alkylating agents Antimetabolites Vinca alkaloids Taxanes Antimitotic antibodies
2
Q
Alkylating agents
A
Alkyl groups allow covalent bonds to other molecules
Attaches to G between DNA strands during replication, preventing replication from taking place as strands cannot separate
3
Q
Antimetabolites
A
Similar to essential metabolites required by the cell prior to mitosis
Can integrate into the nuclear material or bind irreversibly with vital enzymes to prevent division
4
Q
Vinca alkaloids
A
Prevents metaphase by preventing spindle formation
5
Q
Taxanes
A
Promotes spindles and freezes cell at that stage of replication
6
Q
Antimitotic antibodies
A
Anthracyclines and non-anthracyclines
Intercalate to prevent DNA and RNA synthesis
Free radicals disrupt DNA chain and prevent mitosis
