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other blood group Flashcards

1
Q

associated with the secreted
substances

A

Type 1 precursor chain

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2
Q

ISBT of lewis blood group

A

ISBT 007

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3
Q

H substances is also called as

A

precursor material

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4
Q

Type 2 precursor chain location

A

Beta 1-4 linkage ; located between the terminal of D-galactose and N-acetylglucosamine

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5
Q

formation of the ABH antigens or substances
within the red cell membrane

A

type 2 precursor chain

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6
Q

what is the product of the lewis gene

A

Lea soluble antigen

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7
Q

Lewis antigen is also found on

A

pancreas, stomach, intestine, skeletal
muscle, renal cortex, and adrenal glands.

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8
Q

Lea substance is secreted regardless of the
secretor status

A

Le (a+ b-)

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9
Q

The genetically independent Sese, ABO, Hh, and Lewis genes are intimately associated in the formation of the Leb antigen.

A

Le (a- b+)

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10
Q

What phenotype is the result of the genetic
interaction of Lele and Sese genes.

A

Le (a- b+)

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11
Q

Results in point mutation of Le gene, rather than
absence of the Le gene.

A

Le (a- b-)

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12
Q

error when it comes to the DNA
replication for example

A

MUTATION

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13
Q

phenotype of newborn

A

Le (a- b-)

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14
Q

Infants that inherit LE and Se genes:

A

Le (a- b-)
after 10 days
Le (a+b-)
after 6-7 years
Le (a-b+)

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15
Q

lewis phenotype of pregnant women

A

Le (a- b-)

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16
Q

blood groups that exhibit dosage in serologic
reactions:

A

▪ Rh (except D)
▪ Kidd
▪ Duffy
▪ MNSs

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17
Q

Poorly developed at birth

A

lewis antigen

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18
Q

Reactivity is enhanced when treated with

A

proteolytic
enzymes.

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19
Q

Blood that is not affected by Proteolytic enzyme

A

Kell blood groups

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20
Q

THE EFFECT OF PROTEOLYTIC ENZYMES ON
SELECT ANTIGEN-ANTIBODY REACTIONS

enhanced and inactivated

A

Enhanced:
Kidd
Rh
Lewis
P1
I
ABO

Inactivated
Duffy
MNS
Xga/Xg

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21
Q

May cause in vivo hemolysis of red cells

A

lewis antibodies

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22
Q

May cause in vivo hemolysis of red cells

A

Anti-Lea

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23
Q

antibodies produced by Le (a- b-) phenotypes

A

Anti-Lea

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24
Q

no anti-lea production

A

Le (a- b+)

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25
Q

Usually produced by Le(a- b-)

A

Anti-Leb

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26
Q

The Lea antibody is frequently detected with

A

saline suspended cells at room temperature

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27
Q

considered
insignificant in blood transfusion practices.

A

Lewis antibodies

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28
Q

FACTORS CONTRIBUTING TO CLIINICAL INSIGNIFICANCE OF LEWIS ANTIBODIES

A
  • Neutralization of Lewis Antibodies by Lewis
    substances present in the plasma
  • Loss of red cell Lewis antigen(s) into the plasma
  • Lack of reactivity at 37°C and antihuman globulin
    phase
  • Generally IgM in nature and incapable of crossing placenta
  • Lewis antigens poorly developed in newborn infancts
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29
Q

ISBT of MNSs blood group system

A

(ISBT 002)

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30
Q

who discovered MNSs blood group system

A

Landsteiner and Levine in 1927

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31
Q

antithetical antigens.

A

M antigens
N antigens

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32
Q

a pair of antigen that
are coded by different alleles of a single gene

A

Antithetical antigens

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33
Q

discovered S antigen that appeared genetically linked to M and N.

A

Walsh and Montgomery in 1947

34
Q

Antithetical partner of S

A

s antigen.

35
Q

Who discovered U antigen

A

Wiener in 1953

36
Q

Found on a well-characterized glycoprotein known as
GPA.

A

M and N ANTIGEN

37
Q
  • Well developed at birth
A

M and N ANTIGEN

38
Q

Easily destroyed or removed/inactivated by proteolytic
enzymes.

A

M and N ANTIGEN

39
Q

Amino acids of M antigens

A

1st - serine
5th - glycine

40
Q

Amino acids of N antigens

A

1st - leucine
5th - glutamic acid

41
Q

M and N are located at the

A

outer end of GPA

42
Q

S and s ANTIGEN located at the

A

n smaller glycoprotein called GPB (glycophorin B)

43
Q

Amino acid of S antigen

A

Methionine

44
Q

Destroyed or removed/inactivated by proteolytic
enzymes

A

S and s antigen

45
Q

amino acid of s antigen

A

Threonine

46
Q

enzyme that does not destroy S and s
antigens.

A

trypsin

47
Q

U antigen is located on the.

A

Glycophorin B

48
Q

U antigen negative cells are also

A

S-s- or Ss null

49
Q

Who discovered En (a-) antigen

A

Discovered by Darnborough et al., and Furuhjelm
et al.

50
Q

High Frequency antigen

A

En (a-) antigen

51
Q

En (a-) antigen is for envelope in which it will react with all rbcs except

A

propositus

52
Q

Failure to produce Glycophorin A results in

A

En (a-)

53
Q

MNSs ANTIBODIES

A

ANTI-M
ANTI-N
ANTI-Nf
ANTI-S and ANTI-s
ANTI-U
ANTI-M
ANTI-N

54
Q

MNSs antigen

A

M and N ANTIGEN
S and s antigen

55
Q

Anti-N reagent used in laboratory

A

Vicia graminea

56
Q

seen in renal patients, regardless of their MN type,
who are dialyzed on equipment sterilized with
formaldehyde

A

ANTI-Nf

57
Q

is typically IgG and has been reported to cause
hemolytic transfusion reactions and HDN.

A

ANTI-U

58
Q

they have been implicated in severe hemolytic
transfusion reactions with hemoglobinuria

A

ANTI-S and ANTI-s

59
Q

antisera reagent for ANTI-M

A
  • Human source
  • Rabbit source
  • Monoclonal source
60
Q

antisera reagent for ANTI-N

A
  • Monoclonal source
  • Vicia graminea (Lectin source)
61
Q

ISBT of P BLOOD GROUP ANTIGENS

A

ISBT 003

62
Q

Who discovered P BLOOD GROUP ANTIGENS

A

Landsteiner and Levine

63
Q

Injected human RBCs to rabbits and produced
an antibody.

A

Anti-P

64
Q

Made by Pnull individual.

A

anti-Tja/Anti-PP1Pk

65
Q

Found on fetal red cells as early as 12 weeks, but
it weakens with gestational age

A

P1 antigen

66
Q

deteriorates rapidly on storage

A

P1 antigen

67
Q

p1 found in

A

plasma, droppings of pigeon, turtle doves, eggwhite of turtle doves

68
Q

P1 in hydatid cyst fluid,

A

extracts of Lumbricoides
terrestris and Ascaris suum

69
Q

Parasite that is associated with hyadatid cyst

A

Echinococcus granulosus

70
Q

Well developed blood groups at birth for P1 antigen

A

Kell
Kidd
Duffy
MNSs

71
Q

Parasites associated with Anti-P1

A

Fascioliasis (liver fluke),
Clonorchis sinensis and Opisthorcis viverrini
infection.

72
Q

Common, naturally occurring IgM antibody in the sera of P1 individuals

A

Anti-P1

73
Q

Reacts over a wide thermal range

A

Anti-PP1Pk

74
Q

Efficiently bind complement, which makes them
potent hemolysins.

A

Anti-PP1Pk

75
Q

Anti
-PP1Pk→ reacts with all RBCs except

A

auto control and p phenotype

76
Q

Seen in sera of all Pk individuals.

A

alloanti-P

77
Q

Autoanti-P associated with what disease

A

PCH - paroxysmal cold hemoglobinuria

78
Q

The autoantibody typically does not react in
routine test systems but is demonstrable only by

A

Donath-Landsteiner test

79
Q

Isolated from some examples of anti-PP1Pk by
selective adsorption with P1 cells

A

Anti-Pk

80
Q

Anti-Pk Has been reported in the serum of P1 individuals with

A

biliary cirrhosis and AIHA

IMHM (10 decks)

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