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other blood group Flashcards

1
Q

associated with the secreted
substances

A

Type 1 precursor chain

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2
Q

ISBT of lewis blood group

A

ISBT 007

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3
Q

H substances is also called as

A

precursor material

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4
Q

Type 2 precursor chain location

A

Beta 1-4 linkage ; located between the terminal of D-galactose and N-acetylglucosamine

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5
Q

formation of the ABH antigens or substances
within the red cell membrane

A

type 2 precursor chain

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6
Q

what is the product of the lewis gene

A

Lea soluble antigen

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7
Q

Lewis antigen is also found on

A

pancreas, stomach, intestine, skeletal
muscle, renal cortex, and adrenal glands.

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8
Q

Lea substance is secreted regardless of the
secretor status

A

Le (a+ b-)

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9
Q

The genetically independent Sese, ABO, Hh, and Lewis genes are intimately associated in the formation of the Leb antigen.

A

Le (a- b+)

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10
Q

What phenotype is the result of the genetic
interaction of Lele and Sese genes.

A

Le (a- b+)

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11
Q

Results in point mutation of Le gene, rather than
absence of the Le gene.

A

Le (a- b-)

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12
Q

error when it comes to the DNA
replication for example

A

MUTATION

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13
Q

phenotype of newborn

A

Le (a- b-)

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14
Q

Infants that inherit LE and Se genes:

A

Le (a- b-)
after 10 days
Le (a+b-)
after 6-7 years
Le (a-b+)

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15
Q

lewis phenotype of pregnant women

A

Le (a- b-)

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16
Q

blood groups that exhibit dosage in serologic
reactions:

A

▪ Rh (except D)
▪ Kidd
▪ Duffy
▪ MNSs

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17
Q

Poorly developed at birth

A

lewis antigen

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18
Q

Reactivity is enhanced when treated with

A

proteolytic
enzymes.

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19
Q

Blood that is not affected by Proteolytic enzyme

A

Kell blood groups

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20
Q

THE EFFECT OF PROTEOLYTIC ENZYMES ON
SELECT ANTIGEN-ANTIBODY REACTIONS

enhanced and inactivated

A

Enhanced:
Kidd
Rh
Lewis
P1
I
ABO

Inactivated
Duffy
MNS
Xga/Xg

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21
Q

May cause in vivo hemolysis of red cells

A

lewis antibodies

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22
Q

May cause in vivo hemolysis of red cells

A

Anti-Lea

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23
Q

antibodies produced by Le (a- b-) phenotypes

A

Anti-Lea

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24
Q

no anti-lea production

A

Le (a- b+)

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25
Usually produced by Le(a- b-)
Anti-Leb
26
The Lea antibody is frequently detected with
saline suspended cells at room temperature
27
considered insignificant in blood transfusion practices.
Lewis antibodies
28
FACTORS CONTRIBUTING TO CLIINICAL INSIGNIFICANCE OF LEWIS ANTIBODIES
* Neutralization of Lewis Antibodies by Lewis substances present in the plasma * Loss of red cell Lewis antigen(s) into the plasma * Lack of reactivity at 37°C and antihuman globulin phase * Generally IgM in nature and incapable of crossing placenta * Lewis antigens poorly developed in newborn infancts
29
ISBT of MNSs blood group system
(ISBT 002)
30
who discovered MNSs blood group system
Landsteiner and Levine in 1927
31
antithetical antigens.
M antigens N antigens
32
a pair of antigen that are coded by different alleles of a single gene
Antithetical antigens
33
discovered S antigen that appeared genetically linked to M and N.
Walsh and Montgomery in 1947
34
Antithetical partner of S
s antigen.
35
Who discovered U antigen
Wiener in 1953
36
Found on a well-characterized glycoprotein known as GPA.
M and N ANTIGEN
37
* Well developed at birth
M and N ANTIGEN
38
Easily destroyed or removed/inactivated by proteolytic enzymes.
M and N ANTIGEN
39
Amino acids of M antigens
1st - serine 5th - glycine
40
Amino acids of N antigens
1st - leucine 5th - glutamic acid
41
M and N are located at the
outer end of GPA
42
S and s ANTIGEN located at the
n smaller glycoprotein called GPB (glycophorin B)
43
Amino acid of S antigen
Methionine
44
Destroyed or removed/inactivated by proteolytic enzymes
S and s antigen
45
amino acid of s antigen
Threonine
46
enzyme that does not destroy S and s antigens.
trypsin
47
U antigen is located on the.
Glycophorin B
48
U antigen negative cells are also
S-s- or Ss null
49
Who discovered En (a-) antigen
Discovered by Darnborough et al., and Furuhjelm et al.
50
High Frequency antigen
En (a-) antigen
51
En (a-) antigen is for envelope in which it will react with all rbcs except
propositus
52
Failure to produce Glycophorin A results in
En (a-)
53
MNSs ANTIBODIES
ANTI-M ANTI-N ANTI-Nf ANTI-S and ANTI-s ANTI-U ANTI-M ANTI-N
54
MNSs antigen
M and N ANTIGEN S and s antigen
55
Anti-N reagent used in laboratory
Vicia graminea
56
seen in renal patients, regardless of their MN type, who are dialyzed on equipment sterilized with formaldehyde
ANTI-Nf
57
is typically IgG and has been reported to cause hemolytic transfusion reactions and HDN.
ANTI-U
58
they have been implicated in severe hemolytic transfusion reactions with hemoglobinuria
ANTI-S and ANTI-s
59
antisera reagent for ANTI-M
* Human source * Rabbit source * Monoclonal source
60
antisera reagent for ANTI-N
* Monoclonal source * Vicia graminea (Lectin source)
61
ISBT of P BLOOD GROUP ANTIGENS
ISBT 003
62
Who discovered P BLOOD GROUP ANTIGENS
Landsteiner and Levine
63
Injected human RBCs to rabbits and produced an antibody.
Anti-P
64
Made by Pnull individual.
anti-Tja/Anti-PP1Pk
65
Found on fetal red cells as early as 12 weeks, but it weakens with gestational age
P1 antigen
66
deteriorates rapidly on storage
P1 antigen
67
p1 found in
plasma, droppings of pigeon, turtle doves, eggwhite of turtle doves
68
P1 in hydatid cyst fluid,
extracts of Lumbricoides terrestris and Ascaris suum
69
Parasite that is associated with hyadatid cyst
Echinococcus granulosus
70
Well developed blood groups at birth for P1 antigen
Kell Kidd Duffy MNSs
71
Parasites associated with Anti-P1
Fascioliasis (liver fluke), Clonorchis sinensis and Opisthorcis viverrini infection.
72
Common, naturally occurring IgM antibody in the sera of P1 individuals
Anti-P1
73
Reacts over a wide thermal range
Anti-PP1Pk
74
Efficiently bind complement, which makes them potent hemolysins.
Anti-PP1Pk
75
Anti -PP1Pk→ reacts with all RBCs except
auto control and p phenotype
76
Seen in sera of all Pk individuals.
alloanti-P
77
Autoanti-P associated with what disease
PCH - paroxysmal cold hemoglobinuria
78
The autoantibody typically does not react in routine test systems but is demonstrable only by
Donath-Landsteiner test
79
Isolated from some examples of anti-PP1Pk by selective adsorption with P1 cells
Anti-Pk
80
Anti-Pk Has been reported in the serum of P1 individuals with
biliary cirrhosis and AIHA

IMHM (10 decks)

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