OTHER

Question 1

Olaparib

Answer 1

works by trapping PARP to DNA and blocking it from fixing other strand breaks in the DNA
Used for Cancers with BRA1/2mutations

Question 2

Palbociclib

Answer 2

Binds and inhibits CDK4/6 kinase inhibitors
acts directly on the cell cycle

Question 3

Bortemzomib

Answer 3

Inhibitor of proteasome activity
by inhibiting its activity there is accumulation of junk in the cell that leads to cell death

Question 4

5-azacytosine

Answer 4

DNA methylation inhibitor
Covalently binds DNMT enzymes once incorperated into DNA
when inhibiting it causes reactivation of tumor suppressor genes

Question 5

Venetoclax

Answer 5

Inhibits BCL-2 which is used in cancer cells to avoid apoptosis
by inhibiting it causes apoptosis of the cell

Question 6

Pomalidomide

Answer 6

analog of thalidomide
Binds cereblon to ubiquitinate which is used to bring junk to proteasome to degrade but by binding cereblon to it it causes degredation of important factors in multiple myeloma and kaposi sacroma

Question 7

Treatment of myelodysplastic syndrome

Answer 7

5-azacytosine

Question 8

Treatment for multiple myeloma

Answer 8

Bortezomib

Question 9

Treatment for multiple myeloma and kaposi sacroma

Answer 9

Pomalidomide

Question 10

Treatment of lymphocytic leukemia and AML

Answer 10

Venetoclax