endocrine therapies

Question 1

Tamoxifen

Answer 1

SERM
For ER+ cancers
Prodrug that must be metabolized
Pre and postmenopausal women

Question 2

Leuprolide

Answer 2

GNRH analog
causes decrease of LH and FSH but first causes growth then reduction
for prostate cancer and for premenopausal breast cancer

Question 3

Abiraterone

Answer 3

Inhibits 17 alpha hydroxylase and 17,20 lyase no formation of DHT

For prostate cancer

Question 4

Enzalutamide

Answer 4

AR antagonist
prevents movement of androgen receptor to nucleus

Question 5

Exemestane

Answer 5

Steroid aromatase inhibitor
For estrogen responsive breast cancer in postmenopausal women

Question 6

Letrozole

Answer 6

NONsteroidal aromatase inhibitor
selective competitive inhibitor
For postmenopausal breast cancer

Question 7

Fulvestrant

Answer 7

SERD
ER+ metastatic breast cancer in postmenopausal women

Question 8

Treatment for postmenopausal breast cancer

Answer 8

Fulvestrant (ER+)
Letrozole
Exemestane
tamoxifen (ER+)

Question 9

treatment for premenopausal breast cancer

Answer 9

leuprolide
Tamoxifen (ER+)

Question 10

ER+ breast cancer

Answer 10

Fulvestrant (ER+) postmenopausal
Tamoxifen (ER+) pre and postmenopausal