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PHRM 864 > Kinase inhibitors > Flashcards

Kinase inhibitors Flashcards

1
Q

What drugs inhibit EGFR

A

Gefitinib
Osmertinib - works with T790M mutation
Afatinib - covalent
Lapatinib - covalent

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2
Q

Drugs that inhibit HER2

A

Lapatinib - reversible inhibits EGFR and HER2
Tucatinib - inhibitor that preferentially binds to HER

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3
Q

FLT3 inhibitors

A

Midostaurin - First generation
Crenolanib - second generation
Quizartinib - Specific for ITD mutation type II inhibitors

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4
Q

Bcr-Abl inhibtors

A

Imatinib - type II
Ponatinib - inhibits T315I mutation
Involves philadelphia chromosome

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5
Q

inhibitor of ALK

A

alectinib - must get diagnostic test
ALK positive metastatic NSCLC

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6
Q

BRAF inhibitors

A

Dabrafenib - activates wild type BRAF (not good)

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7
Q

Inhibitor of MEK1 and Mek2

A

trametinib - allosteric inhibitor
rash is comon
can be used in combo with Dabrafenib
BRAF V600E/K-mutant metastatic
melanoma

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8
Q

BTK inhibitor

A

Acalabrutinib - Covalent BTK inhibitor

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9
Q

mTOR inhibitors

A

Sirolimus
Everolimus
mTOR is a serine- threonine kinase

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PHRM 864 (15 decks)

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