Immunotherapy - conjugates

Question 1

Trastuzumab Emtansine

Answer 1

TDM1
Binds to HER2 receptor and causes internalization of the receptor and once internalized the other portion of the conjugate is released and inhibits microtubule assembly

second line treatment for HER2 positive metastatic breast cancer

Question 2

Trastuzumab-deruxtecan

Answer 2

acts as an antibody that will bind to HER2 receptors and cause internalization of the receptor and the other portion of the conjugate is released and acts as a topoisomerase I inhibitor that will cleave the DNA strand and cause cell damage