Osteoporosis, Gout, RA Flashcards
3 causes for gout
- increased uric acid production
- decreased uric acid excretion
- increased intake of purine-containing foods
acute gout attacks are classified as how many a year? and what type of meds should they be on?
< 3 attacks/year
should be on ANTI INFLAMMATORY AGENTS
what is our 1st line tx for acute gout attack?
NSAIDs
name some of the main adverse effects of NSAID use
- GI ulceration/bleeding
- impair renal function
- CV events
what is 2nd line tx for acute gout attack? + what’s the prototype?
glucocorticoids : PREDNISONE
when treating acute gout attack (NSAIDs + glucocorticoids) when would we want to see results (decreased pain + inflammation)?
within 24 hours ◡̈
what’s our 3rd choice tx for acute gout attack?
ColChiCine
= aCute
what is our anti-inflammatory prototype for acute gout attack? (3rd choice, if NSAIDs and steroids are out)
colchicine
what is the unique thing about colchicine?
anti-inflammatory effects ONLY with gout
what is the MOA of colchicine?
inhibits leukocyte infiltration –> prevents destructive lysosomal enzymes
what is the MAIN adverse effect of colchicine and what should we do if this occurs?
GI effects –> discontinue drug!!!
describe the dosing for colchicine (initial + max)
1.2mg loading dose –> 0.6mg 1 hour later
MAX: 1.8mg/day
what are the 4 serious/rare AE of colchicine?
- bone marrow suppression
- rhabdomyolysis
- severe kidney disease
- severe liver disease
drug-food interaction with colchicine?
grapefruit juice
if someone has > 3 gout attacks/year, what medication plan should they be on?
PREVENTION of gout (allopurinol)
what is our prototype for drugs that inhibit uric acid formation?
allopurinol
in addition to reducing uric acid levels, allopurinol has 2 more actions r/t gout
- decrease tophi that’s already formed
2. decrease risk of urate crystals in kidneys
what is allopurinol known to do at the START of therapy?
can increase acute gout attacks
SE of allopurinol
GI (mild)
rare/serious AE of allopurinol
hypersensitivity syndrome
“ALL PUR drugs are sensitive”
drug-drug interaction with allopurinol
warfarin
“ALL PUR drugs are SENSITIVE (AE) and don’t like WAR[farin]”
what patient education should we include with allopurinol therapy?
H2O H2O H2O!!!
increase fluid intake to flush out kidneys
what is our “least invasive”/starting point for therapy for osteoporosis + also what all other drug therapies should be paired with?
vitamin supplementation: vit D + calcium
for osteoporosis therapy, what are the 5 classes of drugs that decrease bone resorption (osteoClast)?
- calcitonin-salmon
- biphosphonates*
- estrogen replacement
- SERMs
- Denosumab
for osteoporosis therapy, what is the prototype for drugs that increase bone formation (osteoBlast)?
teriparatide
“teri has this bone para ti (for you)”
“teri is super generous and wants to help you increase your bone formation”
vitamin supplementation for osteoporosis prevention + tx is based on what?
age + intake
how much calcium/day? (woman 51-70yrs)
1200mg
what’s the unique thing about calcium dosing?
body can only absorb 600mg at a time, so dosing should be divided
*calcium carbonate has HIGHEST % of Ca ◡̈ *
what food interactions should you know about with calcium? how can we work around this?
oxalic acid
spinach, beets, rhubarb, swiss chard, brain, whole grains
separate intake of Ca + these foods by 1 hour
how much vitamin D should be supplemented daily?
800-1000mg/day