antifungal, antihelmintic, ecoparasiticide Flashcards
exam 3
superficial fungal infections affect what body components?
skin, scalp, nails, mucus membranes
systemic fungal infections affect what body components?
internal organs (lungs, brain, digestive organs)
which is more rare and difficult to treat (superficial or systemic fungal infection)?
systemic
superficial fungal infections are commonly treated with what type of application?
topical
systemic fungal infections are commonly treated with what type of medication application?
pills or IV meds
populations most at risk for systemic infections
immunocompromised, debilitated, those with transplants, cancer history or with HIV
amphotericin B (amphoterrible) route
IV - central line is preferred
3 major adverse effects of ampho B
- nephrotoxicity
- electrolyte imbalance (K + Mg)
- anemia
3 labs to monitor with ampho B
- BUN, creatinine
- K and Mg
- CBC (H+H)
at what creatinine level should you stop administration of ampho B?
> 3.5
describe administration steps for ampho B
*central line* give 500mL-1L of NS over 1 hour premedicate - tylenol + benadryl change IV tubing for D5 administer ampho B over 4 hours... slooooowwwww give 500mL - 1L NS over 1 hour replace K or Mg
over how many hours should ampho B be given?
4 hours
when administering ampho B, if patient gets rigors, what can you give them?
meperidine (Demerol) or Dantrolene
“azoles” can be given via which routes?
topical, oral, parenteral
prototype for “azole”
itraconazole
3 major adverse events from itraconazole
- GI upset
- cardio suppression
- liver injury