Osteoporosis Flashcards
1
Q
Which therapy is alendronate [Forsamax®] indicated for?
A
osteoporosis therapy
2
Q
What are the 2 indications for alendronate?
A
osteoporosis and Paget’s bone disease
3
Q
Which pathway is inhibited by alendronate?
A
HMG-CoA reductase pathway
4
Q
Osteoclasts/osteoblasts die due to alendronate’s inhibition of the _________ pathway.
A
Osteoclasts die due to alendronate’s inhibition of HMG-CoA reductase pathway.
5
Q
Which other drug class inhibits HMG-CoA reductase pathway?
A
statins
6
Q
Which two ocular side effects are caused by alendronate?
A
uveitis and scleritis
7
Q
Which drug class is alendronate [Forsamax®] under?
A
nitrogenous bisphosphate
8
Q
When alendronate is mixed with NSAIDs it can cause what?
A
An additive GI irritation
