Anti-Hemostatic Agents

Question 1

Extrinsic pathway releases what?

Answer 1

a thrombin burst

Question 2

Coumadin [Warfarin®] is which drug class?

Answer 2

vitamin K antagonist

Question 3

Coumadin blocks ALL THREE of the clotting pathways. It inhibits which K-dependent coagulation factor synthesis?

Answer 3

II, VII, IX, X (and proteins C and S)

Question 4

Azole antifungals, macrolides, fluoroquinolones, and WHAT ELSE cause an impaired coumadin metabolism?

Answer 4

tetracyclines** (TEST QUESTION?)

Question 5

Ocular surgeries and diseases are contraindicated for which anti-hemostatic agents?

Answer 5

• coumadin
• enoxaparin
• clopidogrel
• abciximab

Question 6

Which drug class is enoxaparin and rivaroxaban under?

Answer 6

coagulation factor antagonists; anti-coagulants

Question 7

Which drug class are the following under?:

• clopidogrel [Plavix®]
• ticlopidine
• prasugrel
• dipyridamole

Answer 7

adenosine receptor blockers; platelet inhibitors

Question 8

Which class do the following fall under:

• abciximab
• epitfibatide

Answer 8

Glycoprotein IIb/IIIa receptor antagonists; platelet inhibitors

Question 9

Abciximab and epifibatide when combined with ________ have additive effect of inhibiting COX and therefore TXA2

Answer 9

ophthalmic NSAIDs