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Systemic Pharmacology > Gastrointestinal > Flashcards

Gastrointestinal Flashcards

1
Q 
Which class include:
esomeprazole [Nexium®]
omeprazole [Prilosec®]
lansoprazole
pantoprazole
A

Proton pump inhibitors, PPIs

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2
Q

What does esomeprazole do?

A

irreversibly inhibits gastric parietal cell H+K+–ATPase

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3
Q 
Which drug class includes:
cimetidine
ranitidine [Zantac®]
famotidine [Pepcid®]
nizatidine
A

H2 receptor blockers; histamine-2

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4
Q

Which drug and class:

  • impairs metabolism of caffeine (affecting NSAIDs w/ caffeine)
  • impairs metabolism of cyclosporine
  • impairs ABSORPTION of azole antifungals and certain antiviral agents
A

H2-receptor blockers; cimetidine or ranitidine

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5
Q

What are two serious adverse effects of esomeprazole and omeprazole?

A

SJS and TEN (toxic epidermal necrosis)

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6
Q

__________ inhibits cytochrome P450.

A

Cimetidine

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Systemic Pharmacology (9 decks)

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