Osteoarthritis Flashcards
T/F: Osteoarthritis is not inflammatory
True
What are risk factors of OA
Age, Obesitsy (most preventable), Men younger than 45 or women older than 45, occupation, sports, history of joint injury
What are signs of OA
Pain, Stiffness, crepitus, osteophytes, effusions
T/F: Lab testing for inflammatory markers (ESR/CRP, CBC, and CMP) are good indicators for OA
False: Often inflammatory markers are normal in OA
What is localized OA, generalized OA, erosive OA
1 to 2 sites affected, 3 or more sites affected, erosions present on Xray
What are the non- pharmacological ways to treat OA, what is special about them
Education, Weight loss, Exercise/ Only treatment shown to delay the progression of OA
What are the recommended medications for hand OA, what is preferred if greater than 75
Topical capsaicin, Topical NSAIDs, Oral NSAIDs, Tramadol/ Topical NSAIDs
What are the recommended medications for Knee OA
Acetaminophen, Oral NSAIDs, Topical NSAIDs, Tramadol, Intrarticular corticosteroid injections
What drugs are not recommended for knee OA
Chrondroitin sulfate, Glucosamine, Topical Capsaicin
What is the MOA of acetaminophen, regular dose, lower max dose, monitoring parameters
Block COX in CNS lowering prostaglandin synthesis, 650-1000 every 4 to 6 hours, 2-3 grams, LFTs for chronic use
T/F: Patients have many different individual responses to NSAIDs, ibuprofen may not work but Naproxen will
True
What NSAID is an acetylated salicyclate
Aspirin
What NSAIDs are acetic acids
Etodolac, Diclofenac, Indomethacin, Nabumetone
What NSAIDs are propionic acids
Ibuprofen, Naproxen, Oxaprozin
What NSAIDs are oxicams
Piroxicam and Meloxicam (more COX 2 selective)