Dietary Supplements for Men/Cancer prevention Flashcards
T/F: There is no specific normal or abnormal PSA but trends matter most
True
What are the dietary supplements that men take for BPH
Saw palmetto, Prunus africana, Stingin nettles
Which native american berry is used for BPH
Saw palmetto
What are the two MOAs of saw palmetto
Inhbitis lipoxygenase and cyclooxygenase reducing edema and inflammation, Inhibits 5-alpha-reductase causing less conversion of testosterone to dihydrotestosterone
T/F: Saw palmetto reduces the size of the prostate
False: Saw palmetto does not reduce the size of the prostate
T/F: Saw palmetto use should be evaluated on serum PSA reduction
False: Saw palmetto use should be evaluated by symptomatic improvement
What are possible cautions of saw palmetto
Increased bleeding time, increased LFTs and bilirubin
What can increase the bioavailability of saw palmetto
softgel capsule and eating with a fatty meal
What is the dose for saw palmetto
320 mg daily
What is the african herabal remedy for BPH
Pygeum africana
What are the 3 MOA of pygeum
Inhibits binding of androgen to androgen receptor, inhibitis 5-alpha-reductase (less dihydrotestosterone), inhibits 5-lipoxygenase meabolite production
What is the most used dose for pygeum, when should symptoms improve
75 to 100 mg per day, up to 3 months
When using stingin nettles for the prostate what part of the plant has the best efficacy
Dried roots (Leafs is for allergies)
What are the three MOA of stinging nettles
Inhibits the binding of sex hormone binding globulin to prostate cells, inhibits 5-alpha-reductase, inhibits growth factor activity
What are improvements sen after stinging nettles use
Increase urine volume, reduced serum levels of SHBG, reduced postvoid volume