osteoarthritis Flashcards

1
Q

algorithm treatment for OA

A
education, lifestyle
topical nsaid, paracetamol
oral NSAID
substitute analgesia
add gabapentin/ amitryptilene
-consider tramadol& paracetamol
-strong opiates instead of tramadol
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2
Q

4 main signs of OA on a radiograph

A

joint space narrowing
subchondral sclerosis
subchondral cysts
osteophytes

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3
Q

risk factors for OA 10

A
repetitive adverse loading 
congenital abnormalities
paget
obesity
sex hormones
hereditary
age
trauma 
joint shape
alignment
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4
Q

2 causes of OA

A

primary: idiopathic no identifiable cause (RF)
secondary: clear cause eg trauma, infection, development, pathology

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5
Q

pathophysiology of OA

A
damage to cartilage
chondrocytes compensate
fail to compensate
aggrecan in matrix falls
vulnerable to injury
fibrillation- chondrocyte death
crystals deposited in cartilage
water content increases
osteophyte formation
bone remodelling
synovium hyperplasia 
muscle wasting
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6
Q

symptoms of OA

A
  • functional restriction
  • pain
  • insidious onset over months/yr
  • intermittent
  • pain mostly on movement
  • relieved by rest
  • morning stiffness <30 mins
  • usually only one or a few joints
  • night pain
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7
Q

clinical signs of OA

A

loss of internal rotation and fixed flexion
restricted movement due to capsular thickening
palpable, coarse crepitus
bony swelling around margin
deformity
periarticular tenderness
muscle weakness/ wasting

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8
Q

generalised nodal OA characteristics

A
IPJ OA polyarticular
herbeden and Bouchard 
female 
middle age
predispose to knee OA
genetic predisposition 
pain/ asymptomatic 
postlateral swelling
episodic as nodes develop
common 1st cmcpj joint
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9
Q

knee OA common sites

A

patello-femoral and medial tibio-femoral compartments

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10
Q

knee OA symptoms

A
varus deformity 
women=bilateral
men=trauma unilateral
pain medial aspect 
patello pain going up stairs
Baker's cysts
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11
Q

Knee OA features on exam

A
jerky, antalgic gait
varus/ fixed flexion deformity
joint line tenderness
wasting quads
restricted flexion
bony swelling joint line
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12
Q

Hip OA 2 types

A

superior lateral: freq progress with superolateral migration of femoral head

medial: less common, bilateral, assoc. to generalised, better prognosis

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13
Q

hip OA symptoms

A
deep anterior groin pain
thigh pain
lateral hip pain 
tenderness of greater trochanter
restricted flexion, extension,and hip abduction
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14
Q

hip OA examination

A
antalgic gait
waste quads
ant groin tenderness
restriction/ pain on IR
fixed flexion, ER deformity
ipsilateral leg shortening
superior femoral migration
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15
Q

OA hip grading 0-4

A

0=no radiographic features
1=poss jsn and subtle osteophytes
2=definite JSN, defined osteophytes, some sclerosis
3=marked JSN, small osteophytes, some sclerosis & cyst form, deformity femoral head/ acetabulum
4=gross JSN, large osteophytes and increased deformity of femoral head and acetabulum

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16
Q

early onset OA name and ages

A

kashin beck rare 7-13

17
Q

causes of early onset OA

A

mono=previous trauma
poly=juvenille idiopathic arthritis, metabolic (haemachromatosis, onchronosis, acromegaly), spondyolo epiphyseal dysplasia, late AVN, neuropathic, Kashin beck

18
Q

what is erosive OA

A

rare patients with hand OA with prolonged symptoms

target PIPJ

19
Q

investigation for OA

A

x-ray weight bearing for knees/ non for hip
MRI spine
FBC

20
Q

working dx of OA can be made without an xray if…

A

> 45 years
chronic joint pain >3 months
morning stiffness >30mins

21
Q

other treatments for OA

A

-intra-articular steroids
-TENS and accupuncture
-chondroitin sulphate and glucosamine sulphate
-surgery
arthroplasty, arthrodesis, osteotomy

22
Q

normal structure and function of articular/hyaline cartilage

A
  • Articular cartilage
    o Connective tissue
    o Made of chondrocytes bound in a extracellular matrix
    o Avascular and nourished via synovial fluid
    o Function
     Structure
     Load bearing : deep with perpendicular fibres
     Reduce friction : superficial with parallel collagen fibres and few chondrocytes
23
Q

contents of articular cartilage

A
-	Hyaline articular cartilage
o	Extracellular matrix
	65-80% water by mass
	Type 2 collagen
	Proteoglycans
o	Chondrocytes
	Produces ecm and enzymes
24
Q

what does OA do to articular cartilage

A
  • OA
    o Increases water content which reduces number of cells eg loose chondrocytes so lose cartilage
    o Results in inferior load bearing and increased friction
25
Q

what joints does oa most commonly affect

A

dip and pip
carpometacarpal joints
large joints

26
Q

typical history of OA

A

pain following use
improves with rest
unilateral symptoms- unsymmetrical
no systemic upset