OSMOSIS Liver, Bile and Enterohepatic circ

Question 1

What are the three components of the porta hepatic?

Answer 1

Hepatic artery > delivers oxygen to liver
Hepatic portal vein > delivers nutrient rich blood from GI tract
Common hepatic duct > drains bile from liver into gallbladder

Question 2

What are Kopfer cells?

Answer 2

Macrophages of the liver

Question 3

What are functions of Kopfer cells?

Answer 3

Destroy old RBC, WBC, bacteria, foreign substances

Question 4

What is the precursor of bile salts?

Answer 4

cholesterol

Question 5

What are the components of bile?

Answer 5

Bile salts
Bilirubin
Cholesterol

Question 6

Where is bile made?

Answer 6

In the liver

Question 7

Where is bile stored?

Answer 7

in the gall bladder

Question 8

Explain bilirubin formation

Answer 8

In liver macrophage (Kupfer cell): RBC is destroyed into heme and Fe2+

Heme > biliverdin > bilirubin (unconjugated)

Question 9

What happens to bilirubin once it is formed?

Answer 9

Bilirubin enters bloodstream

Bilirubin binds to albumin

Now bilirubin travels into hepatocyte

It becomes CONJUGATED BILIRUBIN

It is secreted into ballglladder

It is kept there for storage

Upon stimulus, it flows into the intestine

5% becomes stercobilinogen > excreted

95% urobilinogen, of which most is recycles
(small amount goes into urine)