Liver Disease PCP Flashcards
What does the portal triad consist of?
Hepatic artery
hepatic vein
Bile duct
What are causes of high bilirubin?
Pre-hepatic: UNCONJUGATED Gilbert’s, haemolysis
hepatic: cirrhosis, hepatitis
post-hepatic: OBSTRUCTIVE gallstones, pancreatic cancer
How do you measure fractions of bilirubin?
van den Bergh reaction
What is the most common type of paediatric jaundice?
unconjugated bilirubin
What is the most common cause of paediatric jaundice with unconj bilirubin?
Liver immaturity: liver is small and cannot conjugate the bilirubin fast enough
How do you deal with paediatric physiological jaundice?
Phototherapy
What is the mode of inheritance of Gilbert’s syndrome?
Autosomal RECESSICVE
What percentage of the population carries Gilbert gene?
50%
What is bilirubin in Gilbert’s made worse by?=
fasting
What is the most accurate representation of liver function?
Prothrombin time
Because it shows whether the liver is able to make clotting factors
What is the second best representation of liver function?
Albumin
What does hepatitis histology slide look like’
LOTS of fat cells Mallory hyaline Inflammatory cells (neutrophil polumprphs) Fibrosis Megamitochondra
What is the pathway for the liver development in alcohol abuse?
- alcoholic hepatitis
- chronic stable liver disease
- portal hypertension
- cirrhosis
- liver failure
What are traits in portal htn?
caput medusa
ascites
oesophageal varices
splenomegaly
What occurs to the patient’s liver screen in liver failure?
Failed synthetic function
Failed clotting factors, albumin production
Failed clearance of bilirubin
Failed clearance of ammonia (leading to encephalopathy)
