ORUC ET AL (1997) METHOD, DESIGN, SAMPLE Flashcards
1
Q
What experimental method did Oruc et al (1997) use?
A
- Matched Pairs Design (control ppts matched the patient sample in terms of age and sex)
- Quasi-experiment (researchers couldn’t manipulate the IV= bipolar disorder)
- Lab experiment design (used molecular genetic techniques to compare DNA samples from Bipolar patients and control group)
2
Q
How much ppts were in the sample?
A
- 82 ppts (in total)
- Bipolar group- 42 ppts
- Control Group- 40 people
3
Q
How were the (Bipolar) ppts recurited?
A
- 42 bipolar type 1 patients were recruited from 2 Croatian Hospitals.
4
Q
Describe the ‘experimental’/bipolar group?
A
- Type 1 bipolar
- 42 patients from 2 Croatian Hospitals.
- 25 females, 17 males.
- Age Range of 31-70 y/o
- 16 of them had a first-degree relative diagnosed with a major affective disorder like bipolar.
5
Q
Describe the control group
A
- 40 ppts
- No personal (or family) psychiatric histories)
- Matched to the bipolar group on age and gender.
6
Q
Summarise the sample of Oruc et al (1997)
A
- All 82 ppts were from Croatia.
- Bipolar/experimental group: 42 ppts from 2 Croatian hospitals, 25 females, 17 males, 31-70 y/o, 16 had a first-degree relative with MAD (bipolar)
- Control group: 40 ppts without a personal/ family history of psychiatric disorders,
7
Q
Gender- bipolar group?
A
17 males/ 25 females
8
Q
Age- Bipolar group?
A
31-70 y/o
9
Q
Summarise the procedure
A
- Collection of medical records.
- DNA testing
- DNA anaysis
10
Q
Stage 1: Collection of medical records?
A
- The researchers requested family medical records of the ppts to confirm diagnosis of MADs.
11
Q
Stage 2: DNA testing?
A
- DNA testing was carried out to test for polymorphisms in genes RESPONSIBLE for paticular serotonin receptors/ transporters.
- Why? Alterations in these genes can lead to disturbances in specific biochemical pathways associated with depressive disorders.
these genes were the the 5HTR2A and 5HTR2C genes
12
Q
STAGE 3: DNA ANALYSIS
A
The results of the DNA analysis was compared between the control and bipolar group to look for significant factors.
