ORUC ET AL (1997) AIMS, MAIN THEORIES AND IDEAS

Question 1

What was the aim of Oruc et al’s study?

Answer 1

• To investiagte whether specific serotonin-related genes (5HTR2C/5HTTLPR) contribute to the risk of bipolar disorder.

Question 2

Which serotonin-related genes where investigated by the researchers?

Answer 2

• Serotonin Receptor- 5HTR2C
• Sertonin Transporter- 5-HTTLPR

Question 3

Why were these genes studied?

Answer 3

• The researchers wanted to check for polymorphisms in these genes-because these genes are linked to biochemical pathways associated with depressive disorder.

Question 4

When was Oruc et al’s research published?

Answer 4

1997

Question 5

What are some psychological factors assoicated with the onset of bipolar disorder?

Main Context

Answer 5

• Traumatic events (death of loved one, breakdown of relationship)
• Enviromental factors (physical illness, sleep disturbances)

Question 6

What are some biological factors associated with onset of bipolar disorder?

Main Context

Answer 6

• Neurotransmitters- imbalances in serotonin, dopamine, noradrenaline.

Question 7

Why do researchers find it difficult to identify genes associated with bipolar disorder?

Main context

Answer 7

• Complex inheritance patterns and diagnostic difficulties (McGuffin et al 1994)

Question 8

Does bipolar have a heritable component?

Answer 8

• Its thought to be be one of the most likely disorders to be inherited. (The genetic risk for bipolar is 80%)

Question 9

Though specific genes linked to the disorder remain unclear, how does Oruc et al aim to study the genetic causes of Bipolar disoder?

Answer 9

• By examining neurotransmitters associated with the disorder.
• For instance, if the neurotransmitter, serotonin is implicated in the disorder, researchers can then investigate genes involved in regulating serotonin levels to better understand the genetic basis of the disorder.