Oral Path Midterm COPY Flashcards
Define Hamartoma…
Disorganized overgrowth of normal tissue in its normal location
Define Choristoma…
Growth of normal tissue in an abnormal location
Define Neoplasm…
Growth of abnormal tissue, may be either benign or malignant
What are some characteristics of a Benign lesion?
- Bilateral
- Rapid onset (ulceration, soft tissue swelling)
- Pain
- Growth around native structures
- Slow expansion (osseous)
- Smooth root resorption
What are some characteristics of malignant lesion?
- Unilateral
- Chronic, persistent (ulceration)
- Absence of pain/presence of paresthesia
- Invasion/destruction of native structures
- Cortex destruction
- Spiking root resorption
Define Adenoma…
Usually a benign neoplasm: Pleomorphic adenoma, oncocytoma
Define Carcinoma…
- Malignant neoplasm derived from epithelial cells
- Surface (skin, mucosal): Basal cell carcinoma
- Glandular: Adenocarcinoma
Define Sarcoma…
Malignant neoplasm derived from cells of mesodermal origin: Liposarcoma, fibrosarcoma
Define Metastasis…
- Spread of disease from one part of the body to another
- Tumor implants are discontinuous with the primary tumor
What are the 4 differentials for the gum bump differential?
- Fibroma
- Pyogenic Granuloma (Lobular Capillary Hemangioma)
- Peripheral Ossifying Fibroma
- Peripheral Giant Cell Granuloma
POF AND PGCG OCCUR ONLY ON THE GINGIVA!
What are the 4 Human Papilloma Virus Differential?
- Squamous Papilloma
- Verruca Vulgaris
- Condyloma Acuminata (High risk types 16 & 18)
- Heck’s Disease (Multifocal Epithlial Hyperplasia)
What is the differential list for Multilocular Radiolucent Lesions?
MACHO!
M: Myxoma A: Ameloblastoma C: Central Giant Cell Lesion H: Hemangioma (Vascular Malformation) O: Odontogenic Keratocyst Also may be included: - Dentigerous Cyst - Glandular Odontogenic Cyst
What is the differential for Mixed Radiolucent/Radiopaque Differential Diagnosis?
- Adenomatoid Odontogenic Tumor
- Calcifying Odontogenic Cyst
- Ameloblastic Fibro-Odontoma
- Calcifying Epithelial Odontogenic Tumor
- Ossifying Fibroma
- Fibrous Dysplasia
- Desmoplastic Ameloblastoma
Define Odontogenic Cyst…
Cysts lined by odontogenic epithlium
Which odontogenic cysts are inflammatory? Can you name 3?
- Periapical (radicular) cyst
- Residual periapical (radicular) cyst
- Buccal bifurcation cyst
What are the 4 tumors of Odontogenic Epithelium?
- Ameloblastoma
- Adenomatoid Odontogenic Tumor
- Calcifying Epithelial Odontogenic Tumor
- Squamous Odontogenic Tumor
What are some Mesenchymal Odontogenic Tumors? Can you name 3?
- Odontogenic Myxoma
- Central Odontogenic Fibroma
- Cementoblastoma
What are some mixed epithelial/mesenchymal odontogenic tumors?
- Ameloblastic Fibroma
- Fibroodontoma
- Odontoma (considered a hamartoma)
Define Leukoplakia…
White patch that cannot be wiped off, clinical descriptions, not a diagnosis
Define Erythroplakia…
- Red patch or plaque-like lesion that cannot be clinically or pathologically diagnosed as any other condition
- Often represents malignant change: Up to 90% of erythroplakic lesions represent severe epithelial dysplasia, carcinoma in situ, or SCCa
Define Erythroleukoplakia…
- AKA speckled leukoplakia
- Frequently dysplasia or carcinoma in situ on biopsy
Sharply demarcated leukoplakia is concerning for…
Dysplasia!
What percentage of erythropakic lesions represent severe epithelial dysplasia, carcinoma in situ, or squamous cell carcinoma?
90%!
What is the evolution of Proliferative Verrucous Leukoplakia look like?
- Characterized by multiple, persistent, keratotic plaques that over time progress to SCC
- Verrucous hyperplasia leads to…
- Verrucous Carcinoma that leads to…
- Invasive squamous cell carcinoma
- Lesions rarely regress dispite therapy