Oral manifestations of systemic diseases

Question 1

What is wegners granulomatosis

Answer 1

autoimmune disorder of unknown etiology resulting in systemic vasculitis and necrotizinf granulomatous lesions of the respiratory tract

Question 2

What is the most characteristic oral manifestation of wegeners granulomatosis

Answer 2

Strawberry gingivitis florid granular hyperplasia (bumpy hemorrhagic and friable) reported boine destruction and tooth mobility

Question 3

What are you looking for in indirect immunoflourescence for Wegener

Answer 3

c-ANCA clasic anti neutrophil cytoplastic antibodies diffuse cytoplasmic staining pattern

Question 4

IN Wegner what are you looking for with ELISA (Enzyme linked immunosorbent assay

Answer 4

ID antibodies against proteinase 3 confirms positive indirect immunoflourescence

Question 5

What are the halmarks of hyperparathyroidism

Answer 5

Stones bones groans moans brown tumor

Question 6

In hyperparathyroidism what does Stones mean

Answer 6

Kidney stones metastatic calcification within other soft tissue: blood vessel walls sclera, dura, subcutaneous

Question 7

In hyperparathyroidism what does bones mean

Answer 7

subperiosteal resorption of phalanges loss of lamina dura around tooth roos alterations of bony trabecular pattern (ground glass)

Question 8

What is a brown tumor

Answer 8

Name derived from gross apearance due to hemorrhage and hemosiderin well delineated, uni or multilocular radiolucencies mandible clavicles pelvis ribs histology is identical to central giant cell lesion

Question 9

What is osteitis fibrosa cystica

Answer 9

central fibrosis/degredation of brown tumors

Question 10

What is renal osteodystrophy

Answer 10

end stage renal disease with striking jaw enlargement ground glass appearance can cause secondary hyperparathyroidism

Question 11

Whats the def of amyloidosis

Answer 11

a heterogenous group of conditions characterized by the deposition of an extracellular proteinaceous substance (amyloid)

Question 12

How is amyloidosis classified

Answer 12

organ limited systemic

Question 13

what is an amyloid nodule

Answer 13

solitary asymptomatic submucosal deposit composed of aggregates of immunoglobulin light chains focal collections of monoclonal plasma cells may be responsible not associated with systemic alteration this type is RARE in oral soft tissues

Question 14

amyloidosis and multiple myeloma

Answer 14

shared in 15-20% of cases

Question 15

Symptoms of systemic amyloidosis

Answer 15

inisital non specific skin lesions then smooth surfaced firm waxy papules/plaques on eyelid retroauricular region, neck, lips Macroglossia difuse or nodular enlargement of tongue (may be ulcerated) Xerostomia and xerophtalmia if amyloid deposits in the lacrimal and salivary glands

Question 16

What organ system is associated with systemic amyloidosis

Answer 16

end stage renal disease/dialysis