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Dispensing F13 Exam 1 > oral NSAIDs > Flashcards

oral NSAIDs Flashcards

0
Q

antipyretic

A

reduces fever

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1
Q

3 properties of NSAIDs

A

analgesic
antiinflammatory
antipyretic

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2
Q

how do NSAIDs cause GI irritation

A
  • directly because they are irritating substances (food minimizes the direct irritation)
  • indirectly by reducing cytoprotective prostaglandin synthesis
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3
Q

COX-1 action and inhibition

A
  • cox-1 converts arachidonic acid to cytoprotective prostaglandins which stimulates bicarbonate production and mucus production which protect gastric cells from gastric acid
  • inhibition blocks prostaglandin formation and causes irritation
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4
Q

NSAID BBWs

A
  • increased risk of cardiovascular events (stroke, heart attack, etc.)
  • increased risk of GI bleeding
  • contraindicated in pts. allergic to aspirin
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5
Q

Motrin

A

ibuprofen

-NSAID

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6
Q

Naprosyn

A

naproxen

-NSAID

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7
Q

Anaprox DS

A

naproxen sodium

-NSAID

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8
Q

Clinoril

A

sulindac

-NSAID

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9
Q

what is the therapeutic benefit from NSAIDs

A

inhibition of cox-2 which slows prostaglandin synthesis

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10
Q

Feldene

A

piroxicam

-NSAID

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11
Q

Voltaren

A

diclofenac sodium

  • NSAID
  • enteric-coated tablet: TID
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12
Q

Voltaren XR

A

diclofenac sodium

  • NSAID
  • ER tablet: qday
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13
Q

Voltaren Opthalmic

A

diclofenac sodium

  • NSAID
  • QID
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14
Q

Pennsaid

A

diclofenac sodium 1.5% topical solution

  • NSAID
  • ind. for arthritis of the knee
  • QID
  • 40 drops/dose (10 at a time and rub in) X 4 doses/day = 160drops/day
  • contains DMSO
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15
Q

DMSO

A

dimethyl sulfoxide

  • percutaneous absorption enhancer
  • tastes like garlic
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16
Q

Voltaren Gel

A

diclofenac sodium 1% topical gel (QID)

  • NSAID
  • ind. for arthritis joint pain
  • dosing card: 2g or 4g
  • upper extremities: 2g/dose = 8g max/24hr
  • lower extremities: 4g/dose = 16g max/24hr
  • contains alcohol USP as a PEA
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17
Q

PAE

A

percutaneous absorption enhancer

18
Q

Cataflam

A

diclofenac potassium

  • NSAID
  • ind. ONLY for moderate pain
  • tablet: TID
19
Q

Celebrex

A

celecoxib

  • NSAID
  • specific cox-2 inhibitor
  • structurally similar to sulfonamides; DON’T take if allergic to sulfonamides
20
Q

Mobic

A

meloxicam

  • NSAID
  • more cox-2 selective so less GI irritation
21
Q

nabumetone

A
  • NSAID

- more cox-2 selective so less GI irritation

22
Q

etodolac

A
  • NSAID

- more cox-2 selective so less GI irritation

23
Q

indomethacin

A

-NSAID

24
Q

oxaprozin

A

-NSAID

25
Q

ketorolac

A
  • NSAID
  • ONLY ind. for acute pain (not inflammation or chronic pain)
  • causes higher incidence of GI bleeding and ulceration
  • tablet: 5 days MAX (#20) - NO REFILLS
26
Q

Sprix

A

ketorolac nasal spray (QID)

  • NSAID
  • 5 single day spray bottle (1spray/nostril/dose X 4 doses/day = 8 sprays/bottle)
  • must discard spray bottle within 24hr after first spray (can’t guarantee accurate dose after)
  • REFRIGERATE in pharmacy, single day bottle can be at RT for 24hr
27
Q

ketoprofen

A

-NSAID

28
Q

aspirin

A

-NSAID

29
Q

Cambia

A

diclofenac potassium

  • NSAID
  • ind. ONLY for tx of migraines
  • powder for oral solution: 50mg packet - mix with 60mL of water and drink as single dose
30
Q

Solaraze Gel

A

diclofenac sodium 3% topical gel

  • NSAID
  • ind. for actinic keratosis
  • BID
31
Q

actinic keratosis

A
  • a.k.a. AK

- precancerous rough patches of skin caused by UV light

32
Q

other drugs ind. for AK that are not NSAIDs

A

Zyclara cream

Aldara cream

33
Q

Zyclara cream

A

imiquimod 3.75% cream

  • ind. for AK
  • qday x 2weeks, skip two weeks, repeat
34
Q

Aldara Cream

A

imiquimod 5% cream

  • ind. for AK and genital warts
  • BIW X 16 weeks
35
Q

pt. couseling for Zyclara and Aldara

A
  • may want to wear gloves and make sure to put directly on affected spots
  • avoid UV light, may increase sensitivity to sunburn
36
Q

Zipsor

A

diclofenac potassium capsule

  • NSAID
  • ind. for moderate pain
  • QID
37
Q

Flector Patch

A

diclofenac epolamine

  • NSAID
  • ind. for pain due to strains, sprains, and bruises
  • BID: place directly over injury
38
Q

Vimovo

A

naproxen, esomeprazole

  • NSAID, PPI
  • ind. for prevention of NSAID-induced stomach ulcers in pts. needing NSAIDs long-term
  • BID
  • take on an EMPTY stomach, 30min-1hr before meals
39
Q

Cytotec

A

misoprostol

  • prostaglandin
  • ind. for the prevention of NSAID-induced ulcers in pts. taking NSAIDs long-term
  • can be taken with NSAIDs to minimize GI irritation, but most pts. take Arthrotec since it contains misoprostol
  • BBW: do not take during pregnancy (abortifacient)
40
Q

Cytotec MOA

A
  • it is a cytoprotective prostaglandin that stimulates mucus and bicarbonate production and protects gastric cells from gastric acid
  • this action prevents the indirect GI irritation of NSAIDs
41
Q

abortifacient

A

induces abortion

42
Q

Mefeprex

A

mifepristone

  • abortifacient and antiprogestin
  • ind. for the termination of pregnancy: only effective within the first 7 weeks of pregnancy
  • misoprostol is taken a few days after the mifepristone to start contractions (embryo is expelled because of thinned uterus)
43
Q

antiprogestin

A

blocks progesterone receptors in the uterus; lining of uterus thins without progesterone so embryo cannot remain implanted

Dispensing F13 Exam 1 (10 decks)

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