Antiretroviral Agents Flashcards
Zerit XR
stavudine=d4T
-nucleoside RTI
Retrovir
zidovudine=AZT
-nucleoside RTI
Epivir
lamivudine=3TC
-nucleoside RTI
Tyzeka
telbivudine
-nucleoside RTI
Videx EC
didanosine=ddI
- nucleoside RTI
- take on an EMPTY stomach*
Ziagen
abacavir
-nucleoside RTI
Emtriva
emtricitabine
-nucleoside RTI
Viramune
nevirapine
-non-nucleoside RTI
Rescriptor
delavirdine
-non-nucleoside RTI
Sustiva
efavirenz
- non-nucleoside RTI
- take on an EMPTY stomach
Intelence
etravirine
-non-nucleoside RTI
Edurant
rilpivirine
-non-nucleoside RTI
Viread
tenofovir
-nucleotide RTI
Truvada
emtricitabine, tenofovir
- combination RTI
- qdaily
- now approved for prophylaxis of HIV in high-risk adults
Atripla
efavirenz, emtricitabine, tenofovir
- combination RTI
- take on an EMPTY stomach
Combivir
zidovudine, lamivudine
-combination RTI
Epzicom
abacavir, lamivudine
-combination RTI
Trizivir
abacavir, lamivudine, zidovudine
-combination RTI
Complera
emtricitabine, rilpivirine, tenofovir
-combination RTI
Viracept
nelfinavir
- protease inhibitor
- take WITH food
Lexiva
fosamprenavir
- protease inhibitor
- take WITH food
Invirase
saquinavir
- protease inhibitor
- take WITH food
Norvir
ritonavir
- protease inhibitor
- take WITH food
Crixivan
indinavir
- protease inhibitor
- take on an EMPTY stomach
Reyataz
atazanavir
- protease inhibitor
- take WITH food
Aptivus
tipranavir
- protease inhibitor
- take WITH food and also with ritonavir for ritonavir boosting
Prezista
darunavir
- protease inhibitor
- take WITH food and also with ritonavir for ritonavir boosting
Kaletra
lopinavir, ritonavir
- combination protease inhibitor
- take WITH food
Isentress
raltegravir
-integrase inhibitor- another enzyme HIV needs to replicate
Selzentry
maraviroc
-CCR5 antagonist- prevents HIV from entering the T-cell by blocking CCR5 receptors so HIV can’t get inside
Fuzeon
enfuvirtide
- fusion inhibitor- prevents HIV from entering the T-cell by altering the virus and preventing it from fusing to the two receptors
- subQ injection
classes of antiretroviral agents (5)
reverse transcriptase inhibitors protease inhibitors integrase inhibitors fusion inhibitors CCR5 antagonists
3 types of RTIs
nucleoside RTIs
non-nucleoside RTIs
nucleotide RTIs
nucleoside RTIs (7)
Retrovir Zerit XR Epivir Videx EC Ziagen Emtriva Tyzeka
non-nucleoside RTIs - 5
Viramune Rescriptor Sustiva Intelence Edurant
RTI action
inhibit reverse transcriptase which is an enzyme that HIV needs to replicate; disease progression is slowed if inhibited
ind. of antiretroviral agents
treat infections caused by retroviruses
antiretroviral agent pt. couseling
-DON’T SKIP DOSES
what is the point of ritonavir boosting?
when taken with Aptivus, Prezista, and Kaletra; ritonavir inhibits the enzyme that metabolizes these drugs to increase the level of the drug
combination RTIs (6)
Truvada Atripla Combivir Epzicom Trizivir Complera
protease inhibitors (9)
Viracept Lexiva Invirase Norvir Crixivan Reyataz Aptivus Prezista Kaletra
HAART
Highly Active AntiRetroviral Therapy
- used for HIV
- involves taking multiple antiretroviral agents from different classes at the same time
