Medications For Gout

Question 0

hyperuricemia

Answer 0

excessive uric acid in the blood which can lead to gout

Question 1

gout

Answer 1

painful inflammation around a joint caused by uric acid crystals

Question 2

podagra

Answer 2

gout involving the big toe

Question 3

line of treatment for gout

Answer 3

1. NSAIDs and corticosteroids: pain, inflammation
2. colcrys: antiinflammatory
3. Krystexxa: uric acid-specific enzyme

Question 4

Colcrys

Answer 4

colchicine

• antiinflammatory
• 0.6mg tablet
• flare-ups: take 2 tablets initially then take another tablet in 1hr (3 tabs total)
• prophylaxis: qday or BID
• pt. counseling: can sometimes cause stool to be grey

Question 5

Krystexxa

Answer 5

pegloticase

• uric acid-specific enzyme: metabolizes uric acid to allantoin (water soluble so it is excreted in urine)
• only indicated for treatment-resistant gout
• parenteral: every 2 weeks, duration of therapy depends on response
• BBW: severe allergic reactions (25% incidence; must pretreat pt. with corticosteroids and antihistamines)*

Question 6

gout prevention

Answer 6

• change diet

- prophylaxis: Uloric, Zyloprim, or Colcrys (maintenance drugs)

Question 7

Uloric

Answer 7

febuxostat

• xanthine oxidase inhibitor
• ind. for prevention of gout
• qday

Question 8

xanthine oxidase inhibitor MOA

Answer 8

inhibit xanthine oxidase which is an enzyme needed for uric acid production

Question 9

Zyloprim

Answer 9

allopurinol

• xanthine oxidase inhibitor
• ind. for prevention of gout
• qdaily