Anticonvulsants Flashcards

0
Q

generalized seizures

A

affect consciousness

  • tonic-clonic(TC) seizures- jerking, shaking (stereotypical seizure)
  • absence seizures (a.k.a petit mal)- 30 seconds or less, stop mid-action
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1
Q

2 types of seizures

A

generalized seizures

partial seizures

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2
Q

petit mal

A

absence seizure

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3
Q

partial seizures

A
  • a.k.a. focal seizures
  • may or may not affect consciousness (usually do NOT)
  • localized; affect a specific area
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4
Q

pt. counseling for anticonvulsants

A
  • NEVER stop anticonvulsants suddenly–ALWAYS TAPER: status epilepticus may occur
  • may cause somnelence
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5
Q

classes of anticonvulsants

A

barbiturates
succinimides
sulfonamides
hydantoins

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6
Q

barbiturates

A

-decrease effectiveness of hormonal contraceptives
phenobarbital
Mysoline
Mebaral

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7
Q

phenobarbital

A

-barbiturate

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8
Q

Mysoline

A

primidone

  • barbiturate
  • ind. for partial and TC
  • metabolized to phenobarbital
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9
Q

Mebaral

A

mephobarbital

  • barbiturate
  • ind. for TC and absence
  • metabolized to phenobarbital
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10
Q

succinimides

A

-ind. for absence
Zarontin
methsuximide

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11
Q

Zarontin

A

ethosuximide

  • succinimide
  • ind. for absence
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12
Q

methsuximide

A
  • succinimide

- ind. for absence

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13
Q

sulfonamides

A

-ind. for partial
-contraindicated in pts. allergic to sulfa drugs
Zonegran

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14
Q

Zonegran

A

zonisamide

-sulfonamide

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15
Q

hydantoins

A

Dilantin
Peganone
Cerebyx

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16
Q

hydantion counseling

A
  • decrease effectiveness of hormonal contraceptives
  • need to have good dental care (brush AND floss)- may cause gingival hyperplasia
  • chronic alcohol intake may lower the level of drug in the body causing susceptibility to seizures
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17
Q

status epilepticus

A

multiple TC seizures without regaining consciousness

18
Q

gingival hyperplasia

A

gums swell and may cover teeth

19
Q

Dilantin

A

phenytoin

  • hydantoin
  • ind. for partial and TC
  • capsule, chewable tablet, oral suspension, and parenteral
  • parenteral ONLY ind. for status epilepticus
20
Q

Peganone

A

ethotoin

  • hydantoin
  • ind. for partial and TC
21
Q

Cerebyx

A

fosphenytoin

  • hydantoin
  • ind. ONLY for status epilepticus
  • IV only; water soluble prodrug that is converted to phenytoin
  • refrigerate for stability
22
Q

Tegretol, Carbatrol, Epitol

A

carbamazepine

  • anticonvulsant
  • ind. for partial, TC, trigeminal neuralgia, and bipolar disorder
  • BBW: agranulocytosis
23
Q

trigeminal neuralgia

A
  • disorder of the 5th cranial nerve (trigeminal nerve)

- results in face pain

24
Q

agranulocytosis

A

decrease in the number of white blood cells (WBCs) which makes you more susceptible to illness

25
Q

Felbatol

A

felbamate

  • anticonvulsant
  • ind. for partial and Lennox-Gastaut syndrome
  • not a first-line drug; parent must sign consent form saying they have been warned of BBWs
  • BBWs: agranulocytosis, hepatotoxicity, bone marrow suppression
26
Q

Lennox-Gastaut syndrome

A
  • severe, daily seizures of various types with onset in young children (2-3yo) that may continue into adulthood
  • usually have some degree of mental retardation
  • wear a helmet
27
Q

Lamictal

A

lamotrigine

  • anticonvulsant
  • ind. for partial, TC, bipolar, and Lennox-Gastaut syndrome
  • BBW: may cause serious rash
28
Q

Neurontin

A

gabapentin

  • anticonvulsant
  • ind. for partial and pain associated with PHN
29
Q

Horizant

A

gabapentin ER

  • anticonvulsant
  • ind. ONLY for RLS
30
Q

Gralise

A

gabapentin ER

  • anticonvulsant
  • ind. ONLY for PHN
31
Q

PHN

A

postherpetic neuralgia- nerve pain that occurs after shingles blisters have subsided

32
Q

Lyrica

A

pregabalin

  • anticonvulsant
  • ind. for partial, pain associated with PHN, fibromyalgia, and pain associated with DPN
33
Q

DPN

A

diabetic peripheral neuropathy- pain/tingling in the periphery of diabetic pt.

34
Q

Keppra

A

levetiracetam

  • anticonvulsant
  • ind. for partial and TC
  • had no drug interactions for a long time
35
Q

Topamax

A

topiramate

  • anticonvulsant
  • ind. for partial, TC, Lennox-Gastaut syndrome, and migraine prophylaxis
  • side effect: may cause significant weight loss
  • do NOT use in pregnancy- may cause cleft lip/palate in child
36
Q

Depakote

A

divalproex

  • anticonvulsant
  • ind. for partial, TC, absence, bipolar disorder, and migraine prophylaxis
  • BBW: teratogenic effects, four-fold increase in risk of birth defects
37
Q

teratogen

A

an agent that causes birth defects

38
Q

Gabitril

A

tiagabine

  • anticonvulsant
  • ind. for partial
39
Q

Trileptal

A

oxcarbazepine

  • anticonvulsant
  • ind. for partial
40
Q

Vimpat

A

lacosamide

  • anticonvulsant
  • ind. for partial
41
Q

Banzel

A

rufinamide

  • anticonvulsant
  • ind. for Lennox-Gastaut syndrom
42
Q

Sabril

A

vigabatrin

  • anticonvulsant
  • tablet: ind. for partial seizures in adults
  • powder for oral solution: ind. for West Syndrome
  • BBW: can cause permanent vision loss (constricts field of vision, doesn’t make blind)*
  • not a first-line drug
43
Q

West Syndrome

A

severe form of infantile spasms in kids less than 2yo