Oral mucosal lesions Flashcards
_______ cells are actively replicating in the oral mucosa
basal
___________ is superficial CT
lamina propria
What can cause mucosa to look white?
Increased keratin production
Increased thickness of epithelium
_______ is when skin becomes thicker to protect (calluses)
Hyperkeratosis
_______ is thickening of spinous cell layer
Acanthosis
________ is chewing trauma
Frictional keratosis
what is the histology of frictional keratosis?
“holes” in scan of cheek, superficial layer of keratin is shaggy and irregular in its appearance with bacterial colonization
_______ is a fungus that can overgrow in the right environment
Candidiasis
what is the histology like for Candidasis?
-increased keratin layering superficially
-Fungal hyphae noted throughout keratin layer
-Inflammatory cell exocytosis with neutrophils crossing over and collecting in superficial keratin layer
-Acanthosis
-Stains can highlight fungi
______________ is caused by moist occlusion that can cause edema in the tissue
Tobacco pouch keratosis
what is the histology of tobacco pouch keratosis?
-Hyperkeratosis
-Keratin can show chevron pattern
-Acanthosis
-Intraepithelial edema within the cells of the spinous later
________ is swelling/inflammation on mucous membranes that looks like spiderwebs
Lichen planus
what is the histology like for lichen planus?
-Hyperkeratosis
-Acanthosis
-Atrophy: areas of reduced thickening, can produce angular rete ridges
-Basal cell degeneration by inflammatory cells as well as inflammatory cell exocytosis into the epithelium
-Thickening of basement membrane zone
-Lamina propria shows superficial band like inflammatory cell infiltrate that is predominantly lymphocytic
________ is a precancerous clinical diagnosis
Leukoplakia
what are high risk cancer sites in the mouth?
lateral/ventral tongue, floor of mouth
what is the histology of Leukoplakia?
-Rete ridges look rounder/more bullous
-Cell crowding
what is the histology like of geographic tongue?
-Acanthosis
-Inflammatory cell exocytosis with neutrophils crossing over into the epithelium
-Aggregates of neutrophils noted in the superficial keratin and spinous cell layer
________ is a clinical sign in which the gingiva appears reddish, glazed and friable with destruction of the epithelium
Desquamative gingivitis
Clinical diagnosis of Desquamative gingivitis should include these following entities in a differential:
- lichen planus
- pemphigoid
- pemphigus
_________ is the ability to produce a blister/slough tissue via physical pressure
Nikolsky sign
what is the histology like of squamous cell carcinoma?
-Will show varying degrees of dysplastic change in the surface epithelium and invasive islands of atypical epithelial cells within the underlying CT
-Invasive islands are the defining feature
-keratin “pearl”
- abnormal mitosis
______ is a single large dilated vessel
Varix
________ is a proliferation of blood vessels within the underlying CT
Hemangioma
_________ is a freckle-like, increased, melanin pigment deposition within the basal cell layer and often evidence of incontinent melanin pigment within superficial lamina propria
Melanotic macule
______ is a disruption/loss of epithelium
Ulceration
what is histology like in ulceration?
-loss of epithelium where epithelium is replaced by fibrinous exudate suspending inflammatory cells
-Underlying cell bed will consist of granulation tissue with subacute to chronic inflammation
-Looks like a canal
what are the 3 types of ulceration?
-Aphthous ulcers (canker sores)
-Tugse: traumatic ulceration
-lichen planus
what does lichen planus ulceration look like?
ulceration surrounded by striation
__________ is an epithelial hyperplasia and papillary architectural change
Papillary surface change
what is papilloma a result of?
HPV
_________ is low risk HPV, like skin warts
Verruca vulgaris
what is histology like for verruca vulgaris?
-papillary epithelial hyperplasia with prominent large intensely staining keratohyalin granules
-Papillary fronds will be parakeratotic
-Rete ridges at the periphery of the papillary proliferation will converge centrally
what is this a scan of?
frictional keratosis
what are these scans of?
Candidasis
what is this a scan of?
tobacco pouch keratosis
what is this a scan of?
lichen planus
what is this a scan of?
sqamous cell carcinoma
what is this a scan of?
mucous membrane pemphigoid
what is this a scan of?
phemphigus vulgaris
what is this a scan of?
Varix
what is this a scan of?
melanotic macule
what is this a scan of?
ulceration
what is this a scan of?
Verruca vulgaris
