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CEE 1 > [ORAL EXAM] Pharm Analysis > Flashcards

[ORAL EXAM] Pharm Analysis Flashcards

1
Q

Concerned with either the identification or quantification of one or more substances in a given sample of pharm interest

A

Pharmaceutical Analysis

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2
Q

Reveals the identification of an element or compound in a sample

A

Identification

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3
Q

The totality of characteristics or features of a product that bear on its capacity to satisfy stated or implied needs

A

Quality

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3
Q

Determination and exact amount of an exact analyte

A

Quantification

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4
Q

Responsible for operation and process

A

Quality Assurance

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4
Q

Sum total of organized arrangements made with the objective of ensuring that products are of the quality required for their intended use

A

Quality Assurance

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5
Q

Part of CGMP concerned with sampling, specification, testing, organization, documentation

A

Quality Control

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6
Q

Responsible for testing and sampling of the drug products

A

Quality Control

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7
Q

Process Oriented

A

Quality Assurance

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8
Q

Product Oriented

A

Quality Control

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9
Q

Document that contains a list of tests, references to analytical procedures and appropriate acceptance criteria

A

Specification

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10
Q

A written standard that describes an article like a drug substance, drug product, excipients or compounded preparation

A

Monograph

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10
Q

A collection of data gathered and presented in the form of a book

A

Compendia

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11
Q

Universal Tests: Appearance Testing

A

Description

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12
Q

less than 1mg

A

Ultra Microanalysis

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12
Q

Universal Tests: Threshold presence of related degradation substances in the drug sample

A

Impurities

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12
Q

Universal Tests: Quantitative measure of compound in a sample

A

Assay

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12
Q

100ppm - 1000ppm

A

Trace Analysis

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13
Q

1mg - 10mg

A

Micro Analysis

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13
Q

Universal Tests: Verification of Identity

A

Identification

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14
Q

10mg-100mg

A

Semi-Microanalysis

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15
Q

100mg+

A

Macroanalysis

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15
Q

Nature of method based on chemical reactions

A

Classical Methods

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16
Q

Total amount of a single and specific compound

A

Ultimate analysis

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16
Q

Total amount of a group or class of compounds

A

Proximate analysis

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17
Q

Nature of method based on physical and chemical properties of analyte

A

Instrumental Methods

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18
Q

Nature of method that deals with crude drugs or natural products

A

Miscellaneous/Special Methods

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19
Q

Aka Accuracy

A

Trueness

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20
Q

Error in analysis

A

Accuracy

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20
Q

Closeness of an actual value to the theoretical/true value

A

Accuracy

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21
Q

Closeness of an actual value of 2 or more test results to each other

A

Precision

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22
Q

Precision under the same laboratory but with different analysts

A

Intermediate

Within-Laboratory

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22
Q

Precision under the same operating conditions in a short period of time

A

Repeatability

Intra-assay

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23
Q

Due to factors external to the method

A

Ruggedness

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24
Q

Express variation between laboratories

A

Reproducibility

Inter-laboratory

25
Q

Due to factors internal to the method

A

Robbubstness

25
Q

A measure or capacity to remain unaffected by deliberate variations in method

A

Robustness or Ruggedness

26
Q

AKA Specificity

A

Selectivity

27
Q

Referred to as the slope of callibration curve

A

Sensitivity

27
Q

Ability to asses the analyte in the presence of other substances

A

Specificity

28
Q

Ability to discriminate between small differences in analyte concentration

A

Sensitivity

29
Q

Ability to obtain results of variable data which is directly proportional to the concentration in the sample

A

Linearity

30
Q

Defined as the difference in numerical values between a measured value and the true value

A

Error

31
Q

AKA Random Error

A

Indeterminate Error

32
Q

AKA Systemic Error

A

Determinate Error

33
Q

Error that affects precision

A

Random Error

34
Q

Error that affects accuracy

A

Systemic Error

35
Q

Titrimetry is also known as?

A

Classical Methods

36
Q

Involves solution of reagent of known concentration added to a solution of analyte until reaction is judged complete

A

Titrimetry

37
Q

Titrant is also known as?

A

Standard Solution/Volumetric Solution

38
Q

Titrand is also known as?

A

Analyte/Sample

39
Q

Reagent of known concentration

A

Titrant

40
Q

Reagent of unknown concentration

A

Titrand

41
Q

Complex organic compounds capable of changing colors which aid in the visualization of the endpoint

A

Indicator

42
Q

Actual point at which the reaction is observed to be complete

A

End Point

43
Q

The point at which a chemically equivalent of titrant has reacted with analyte

A

Equivalence Point

44
Q

Equivalence Point AKA?

A

Stoichiometric Point/Theoretical Point

45
Q

Process of determining the exact concentration of a titrant/standard solution

A

Standardization

46
Q

Substance of high degree of purity

A

Primary Standard

47
Q

Makes use of indicators to make observation of endpoint possible (Can be indicated by Titration)

A

Visual Titration

47
Q

Prepared from primary standard

A

Secondary Standard

48
Q

Equivalence point is signified by a sharp change in potential of the solution

A

Potentiometric Titration

49
Q

Equivalence point is signaled by a change in electrical conductivity

A

Electrometric Titration

50
Q

Analyte is reacted with Titrant after rendering it soluble in titration medium

A

Direct Titration

51
Q

Analyte undergoes preliminary treatment prior to titration

A

Indirect Titration

52
Q

Indirect titration uses this to convert sample to another compound

A

Auxiliary Reagent

53
Q

Two titrants are used wherein one VS is added in excess then unreacted excess is back titrated with the other VS

A

Residual Titration

54
Q

The difference between the end point and the stoichiometric point

A

Blank Titration

55
Q

Titration with no analyte

A

Blank titration

56
Q

SA+SB

A

Phenolphthalein
Methyl Orange
Methyl Red

56
Q

What is the titrant and titrand in Acidimetry

A

Titrant: Acid
Titrand: Base

56
Q

What is the titrant and titrand in Alkalimetry

A

Titrant: Base
Titrand: Acid

57
Q

WA+SB

A

Phenolphthalein

58
Q

WA+WB

A

No indicator

59
Q

SA+WB

A

Methyl Orange, Methyl Red

60
Q

Azo Dyes: What color does Methyl orange give to Acid and Base?

A

Acid: Pink
Base: Yellow

60
Q

Azo Dyes: What color does Methyl yellow give to Acid and Base?

A

Acid: Red
Base: Yellow

61
Q

Azo Dyes: What color does Methyl red give to Acid and Base?

A

Acid: Red
Base: Yellow

62
Q

Phthalein: What color does Thymolphthalein give to Acid and Base?

A

Acid: Colorless
Base: Blue

62
Q

Volumetric Solution of Aqueous Acidimetry

A

HCl and H2SO4

62
Q

Phthalein: What color does Phenolphthalein give to Acid and Base?

A

Acid: Colorless
Base: Pink

63
Q
A
64
Q
A
65
Q
A
66
Q
A

CEE 1 (12 decks)

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