Optics: Ant Seg. OCT Flashcards
OCT is a non-contact imaging technique which generates ___________ images of tissue
Cross-sectional
Coherent light has waves of light that are __________
In phase
Incoherent light has waves of light that are __________
Out of phase
Constrictive interference occurs when ____________
Waves combine
Destructive interference occurs when ___________
Waves cancel each other out
Interferometry is a method that uses ________________ to extract information
Interference of waves
Low-coherence light ensures that what contributes to the interference signal?
Only light from a narrow depth range
How does low-coherence light imaging impact retinal imaging?
Allows accurate layer-by-layer imaging
Why do we not need high coherence length for imaging the retina?
Because the retina is thin and layers are very close to each other
How does low-coherence light in OCT imaging impact axial resolution?
Increases axial resolution
OCT uses light in the near-infrared, which travels ________ than ultrasound
Much Faster
With Time-Domain OCT: light from the source is split into _________ and _______
Reference beam and central beam
OCT works by measuring the _________ and __________ reflected from different depths within the sample
Time delay and intensity of light
By using a reference arm, interference occurs only when the optical path difference between the sample and reference arms is within the ____________________
Coherence length of the light source
Anterior segment OCT: wavelength
1310 nm
Anterior segment OCT systems show __________ absorption and __________ penetration
Less absorption and deeper penetration
Retinal OCT: wavelength
830 nm
Retinal OCT systems have better ________ resolution
Axial
What was the first generation OCT?
Time-Domain OCT
What was the 2nd generation OCT?
Spectral Domain
What was the 3rd generation OCT?
Swept-Source OCT
Time-domain OCT relied on a moving _________ to do what?
Relied on a moving mirror to scan each depth position, pixel by pixel
Did the time-domain OCT have to be physically moved?
Yes to scan various depth or layers
Fourier Domain OCT has a _________ reference arm
Fixed
Fourier Domain OCT Light Source:
Broadband light source (840-850 nm)
Broadband light source in Fourier domain OCT produces a ____________________
Spectrum of backscattered light
Backscattered light in Fourier Domain OCT is measured by a _____________
Spectrometer
With Fourier Domain OCT, the frequency components of backscattered light can be analyzed either ____________ or ____________
Spatially (Spectral Domain OCT)
Temporally (Swept Source OCT)
5 Advantages of Fourier Domain OCT
- High speed
- High resolution
- Layer-by-layer assessment
- Larger scanning areas
- 3D scanning
Scanning speed of Time Domain vs. Fourier Domain
Time Domain: 400 A-scans/sec
Fourier Domain: 26,000 A-scans/sec
Depth Resolution of Time Domain vs. Fourier Domain
Time Domain: 10-15 microns
Fourier Domain: 5 microns
B-Scan time of Time Domain vs. Fourier Domain
Time Domain: 1.3 secs
Fourier Domain: 0.04 secs
Reference mirror of Time Domain vs. Fourier Domain
Time Domain: Moving
Fourier Domain: Stationary
Motion Handling of Time Domain vs. Fourier Domain
Time Domain: Slower than eye movement
Fourier Domain: Faster than eye movement
Image quality of Time Domain vs. Fourier Domain
Time Domain: Lower
Fourier Domain: Higher
What is the advantage of Spectral Domain OCT having such a fast scanning speed?
Helps to minimize motion and possible artifacts
Comparison of Anterior segment OCT and Retinal OCT wavelength of light source
Anterior segment uses a higher wavelength light source (1310 nm) compared to Retinal OCT (840 nm)
Anterior Segment OCT: What is a Line scan?
A cross-sectional view of the cornea or anterior chamber angle
Anterior Segment OCT: What is a Raster scan?
Series of parallel line scans. Allows for more comprehensive assessment of corneal thickness and pathology
Anterior Segment OCT: What is a Radial scan?
Multiple scans radiating from the center of the cornea or angle to assess symmetry and depth
Anterior Segment OCT: What is a Pachymetry Map?
A thickness map of the cornea used to evaluate corneal thinning or edema
What type of OCT imaging is important when diagnosing conditions like corneal dystrophies, keratoconus, narrow-angle glaucoma, and post-surgical complications?
Anterior segment OCT
What type of OCT imaging is important when diagnosing conditions like age-related macular degeneration (AMD), diabetic macular edema, retinal detachments, and epiretinal membranes?
Posterior segment OCT
What type of OCT imaging would help assess swelling of the cornea?
Anterior segment OCT
What type of OCT imaging would help assess corneal ulcers?
Anterior segment OCT
What type of OCT imaging would help assess Pterygium?
Anterior segment OCT
What type of OCT imaging would help assess open and closed angle evaluations?
Anterior segment OCT
What type of OCT imaging would help assess anterior chamber depth?
Anterior segment OCT
Does OCT provide a pachymetry map? What does a Pachymetry map show us?
Yes, pachymetry map shows us corneal thickness across the entire cornea.