OPP Final 12/19/2022 Flashcards
Free nerve endings that are non-encapsulated, responsive to noxious stimuli
Nociceptors
Two types of pain fibers
- A(delta) - responsive to intense and mechanical stimuli; myelinated fast
- C fibers - responsive to various stimuli; non myelinated so thinner
How is pain suppressed?
The brain sends signals to inhibit pain input, blocking signals, also substance P inhibits AP from pain receptors. Interneurons change polarity of post synaptic so it can’t receive info from presynaptic neurons, usually inhibitory
What are two pathway of ALS (anterior lateral system)?
primary neuron is afferent, secondary are neurons in thalamus, and third is neurons in cortex. Neospinothalamic - fast adelta fibers, glutamate mediated, terminates in brain stem, thalamus, and lamina. Paleospinothalamic tract - slow C types, glutamte and substance P mediated
Describe the brain’s analgesia system.
Brain can suppress afferent pain signals. Periaqueductal gray and periventricular areas send signals to the raphe magnus nucleus. These efferent signals then travel to the pain inhibitory complexes in the dorsal horns of the spinal cord this blocks further afferent pain signals and withdrawal reflexes
How is pain suppressed?
Brain blocks afferent signals, pain receptors barely adapt so this makes you aware of tissue damage persisting
What does the ALS examine?
pathways to consciousness via secondary neuron to thalamus, and tertiary neuron to cortex
Fast Adelta fibers, glutamate mediated, terminate in lamina, excites second order neurons, decussate through anterior commissure, and terminates in brain stem/thalamus
Neospinothalamic
Older system, slow C fibers, glutamate and substance P mediated, terminate in lamina, excite second order neurons, decussate through anterior commissure
Paleospinothalamic
What is analgesia systems?
Periaqueductal gray and periventricular signals areas to raphe and nucleus reticularis. Brain suppresses affents via efferents that go to pain inhibitory complexes of dorsal horn.
How do drugs inactivate pain pathways
Exogenous opiates, endogenous opiates, these bind to mu receptors in brain and spinal cord which alter excitability of receptors. OMM can increase endogenous opoids
What are characteristics of visceral pain?
C type fibers, recruits nerves T1-S2, thalamus relays to insular cortex. You can’t always tell where pain is coming from because convergence of multiple AP
A non-noxious stimulus is painful
allodynia
How does sensitization occur?
raised resting membrane potential causes neuron to exists in a hyper-excitable state, less stimuli is required for AP. Leads to allodynia
A noxious stimulus is more painful than expected
Hyperalglesia
Greater noxious stimulus is required to trigger AP with pain shooting directly to max. intensity and long lasting
hyperpathia
Maintenance and Exacerbation of somatic dysfunction is cased by…
chronic inflammation, vasoconstriction, and muscle spasm
What are some red flags for back/costal pain?
bladder/bowel incontinence, acute onset for kids and elderly, neuro defects, explained weight loss/gain, IV use, immunosuppression, or history of malignancy
Funneled breast, genetically from marfan’s, cobbler chest. Associated with mitral valve prolapse, can compromise cardio pulm
Pectus excavatum
Pigeon breasted, comes from rickets, marfan’s, Congenital heart disease, kyphoscoliosis
Pectus carinatum
Kyphosis, COPD, emphysema
barrel chest
Rib Fracture
very localized, stabbing piercing pain treat with OMM on opposite side, C3-C5 treatment. Also use braces, opiates unless respiratory dysfunction, no injections