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Anesthesia Meds > Opioids > Flashcards

Opioids Flashcards

1
Q

Morphine Dose

A

Intra: 1- 10 mg
PostOp: 2- 10 mg

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2
Q

Fentanyl Dose + Trade Name

A

Sublimaze

1 - 3 mcg/kg

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3
Q

Sufentanil Dose

A

Intra: 0.3 - 1 mcg/kg
Infusion: 0.5 - 1 mcg/kg/hr

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4
Q

Remifentanil Dose + Trade Name

A

Ultiva

DOSED on IDEAL BW

Loading 0.5 - 1 mcg/kg over 1 min
Infusion: 0.125 - 0.375 mcg/kg/min

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5
Q

Meperidine Dose + Trade Name

A

Demerol

Used for Post-op shivering

12.5 mg

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6
Q

Hydromorphone Dose + Trade Name

A

Dilaudid

Intra: 1- 4 mg
PostOp: 1.5 - 4 mg

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7
Q

Naloxone Dose + Trade Name

A

Narcan

40 - 80 mcg

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8
Q

Morphine Onset

A

10 - 20 min

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9
Q

Morphine Duration

A

4 - 5 hr

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10
Q

Fentanyl Onset

A

30 - 60 sec

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11
Q

Sufentanil Onset

A

30 - 60 sec

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12
Q

Fentanyl Duration

A

1 - 1.5 hr

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13
Q

Sufentanil Duration

A

1 - 1.5 hr

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14
Q

Remifentanil Onset

A

30 - 60 sec

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15
Q

Remifentanil Duration

A

6 - 8 min

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16
Q

Meperidine Onset

A

5 - 15 min

17
Q

Meperidine Duration

A

2 - 4 hr

18
Q

Hydromorphone Onset

A

5 - 15 min

19
Q

Hydromorphone Duration

A

2 - 4 hr

20
Q

Naloxone Onset

A

1 - 5 min

21
Q

Naloxone Duration

A

30 min

22
Q

Mu1

A

Analgesia
Euphoria
Miosis
Bradycardia
Hypothermia
Urinary Retention

23
Q

Mu2

A

Analgesia
Resp Depression
Physical Dependence
Constipation

24
Q

Kappa

A

Analgesia
Dysphoria
Sedation
Miosis
Diuresis

25
Q

Delta

A

Analgesia
Resp Depression
Dependence
Urinary Retention

26
Q

Opioid MOA

A

Activate mu, kappa, and delta receptors

Presynaptic inhibition of acetylcholine, dopamine, norepinephrine, Substance P

Decreased calcium channel activity
Increased potassium conductance
Hyperpolarize cell

27
Q

Morphine Pharmacodynamics

A

Primarily mu 1 & mu 2

Active metabolite Morphine -6- glucuronide
Poor lipid solubility
Highly protein bound
Clearance: Renal

28
Q

Fentanyl Pharmacodynamics

A

Mu 1 & Mu 2

Lipid Soluble
Non ionized form high in physiologic pH
Active metabolite: norfentanyl
Metabolism: Hepatic P450s
Clearance: Renal

29
Q

Sufentanil Pharmacodynamics

A

Mu 1 & Mu 2

Lipid soluble
Metabolism: Hepatic
Clearance: Renal & Fecal

30
Q

Remifentanil Pharmacodynamics

A

Mu 1 & Mu 2

lipid soluble
Metabolism: Plasma esterases
Clearance: Renal

31
Q

Meperidine Pharmacodynamics

A

mu1, mu2, kappa

Active metabolite: normerperidine
Metabolism: Hepatic
Clearance: Renal

32
Q

Hydromorphone Pharmacodynamics

A

Mu 1 & Mu 2

Water soluble
Metabolism: Hepatic

33
Q

Naloxone Pharmacodynamics

A

Nonselective for Mu, Delta, Kappa

Opioid antagonist

Metabolism: Hepatic

34
Q

Morphine E 1/2 time

A

2-3 hours

35
Q

Naloxone E 1/2 time

A

1 - 1.5 hours

36
Q

Hydromorphone E 1/2 time

A

3 - 5 hours

37
Q

Remifentanil E 1/2 time

A

6 min

38
Q

Sufentanil E 1/2 time

A

2-5 hours

39
Q

Fentanyl E 1/2 time

A

3-7 hours

Anesthesia Meds (10 decks)

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